Research

Lab Focus

The focus of the research labs in the department centers on the effects of local anesthetic toxicity on peripheral nerves and possible neural regeneration after these insults. The presentation “Bupivacaine exacerbates facial motoneuron axotomy-induced cell death” is indicative of the type of research activity in this lab. The lab is also assessing recovery from nerve paralysis with Bell’s Palsy using electrical stimulation of the facial nerve.

Clinical studies are conducted at both Loyola University Foster G. McGaw Hospital inpatient and outpatient facilities along with clinical areas at Hines VA Hospital. Our Pain Division Director, Dr. Joseph Holtman, is involved with opioid analogue research and has actively been investigating opioid-induced bowel dysfunction in patients with chronic pain of non-malignant origin. Other studies have looked at the effects of non-peptide small molecular antagonists of α9 and α10 nicotinic acetylcholine receptors on chronic pain in rats.

The department also has interest in chronic pain treatment and has been particularly interested in patients on long term chronic opioids and the development of opioid-induced hyperalgesia. Studies are contemplated in assessing this issue in burn patients who have multiple painful procedures and who receive long-term opioid treatment for pain. Different strategies for pain management have been studied and the focus of this work is noted in a recent publication devoted to pain management in these patients (Opioid Induced Hyperalgesia and Burn Pain, J Burn Care Res 2012; 32:692-701).

Other studies have focused on chronic pain after spinal cord injury and are evaluating different techniques to reduce opioid use and possible hyperalgesic effects in these patients. Studies evaluating the effects of medications such as carbamazepine and memantidine on opioid use and pain sensitization in spinal cord injury patients are being developed for the spinal cord rehabilitation unit at Hines VA Hospital. Neuropathic pain is often debilitating and clinical research such as this is helping to reduce the dependence on opioids with alternative forms of therapy.

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Recent Publications

Journal Articles

Abdelfattah BA, Buck T, Byram S. Epidural Hematoma after the Use of Subcutaneous Unfractionated Heparin and History of Epidural Tumor. Scientific Research. Open Journal of Anesthesiology, 2014, 4, 163-166. http://dx.doi.org/10.4236/ojanes.2014.47023.

Byram SC, Ault M. Con: The Challenges of Utilizing Expanded-Criteria Donors for Orthotopic Heart Transplantation. J Cardiothorasic and Vascular Anesthesia. (In press)

Fierro M, Mukherji J, Sheikh T. Intraoperative Transesophageal Echocardiography to Evaluate Acute Cessation of Venous Inflow during Cardiopulmonary Bypass. Cases-anesthesia-analgesia.org, Volume 3, Number 8, 2014.

Gupta, RA. Review of the book Liver Anesthesiology and Critical Care, edited by Gebhard Wagener. Anesthesiology. 2014 Jul; 121:206-7.

Jellish WS. Editorial for Manuscript: Checklist for Anesthesiological process: analysis of risks. Minerva Anestesiologica 2014; 80 (8): 871-73.

LeVan P, O’Rourke M, Khan T. Current use of Ultrasound Transmission Gel for Transesophageal Echocardiogram Examinations by the Cardiothoracic Anesthesiology Fellowship Directors. Journal of Cardiothoracic and Vascular Anesthesia. (Accepted)

Mikhael M, Takabayashi K (2015). Lesson 315: Assessment of the Neonate with a Patent Ductus Arteriosus. Anesthesiology News, April 2015, Icahn School of Medicine at Mount Sinai, Department of Anesthesiology PreAnesthetic Assessment CME Series, New York, NY.

Mukherji J, Hood R, Edelstein S. Overcoming Challenges in the Management of Critical Events During Cardiopulmonary Bypass. Semin Cardiothorac Vasc Anesth 2014; 18:190-207. DOI: 10.1177/1089253214526646.

Murray A, Wiisanen M. “APEP Anesthesiology Preceptorship Enrichment Program” A Popular Student Curriculum AND a Recruiting Tool?” Journal of Education in Perioperative Medicine. (Accepted)

Odom-Forren J, Hooper V, Moser D, Hall L, Lennie T, Holtman J, Thomas,M, Centimole Z, Rush C, Apfel C. Postdischarge Nausea and Vomiting: Management Strategies and Outcomes Over 7 Days. J. PeriAnesthesia Nursing: 29: 275-284, 2014.

O'Brien LM, Bullough AS, Chames MC, Shelgikar AV, Armitage R, Guilleminualt C, Sullivan CE, Johnson TR, Chervin RD. Hypertension, Snoring, and Obstructive Sleep Apnoea during Pregnancy: A Cohort Study. BJOG: An International Journal of Obstetrics & Gynaecology. 121(13):1685-93, 2014 Dec.

O’Rourke M, Levan P, Khan T. Current Use of Ultrasound Transmission Gel for Transesophageal Echocardiogram Examinations: A Survey of Cardiothoracic Anesthesiology Fellowship Directors. J Cardiothorac Vasc Anesth. 2014 Oct;28(5):1208-10.

Saeed HN, Presta MV, Yoo D. Subperiosteal Haematoma After General Anaesthesia. British Journal of Anaesthesia, 2014, 112: 772-773 doi: 10.1093/bja/aeu084.

Salazar D, Sears B, Acosta A, Aghdasi B, Francois A, Tonino P, Marra G. Effect of Head and Neck Positioning on Cerebral Perfusion during Shoulder ArthroscopyiIn Beach Chair Position. Journal of Surgical Orthopaedic Advances. 23(2):83-9, 2014.

Stauble ME, Moore AW, Langman LJ, Boswell MV, Baumgartner R, McGee S, Metry J, Jortani SA. Hydrocodone in postoperative personalized pain management:pro-drug or drug?. Clin Chim Acta. 2014 Feb.15; 429: 26-9.

Sutton E, Pietrzak A. Indigo Carmine-Induced Hypotension in a Parturient with Idiopathic Pulmonary Artery Hypertension, Hypertrophic Cardiomyopathy, and LAD Myocardial Bridging. Jour. Cardiothoracic and Vascular Anesthesia, 2015. 02. 013.

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Abstracts

Abdelfattah B, Buck T. Epidural Hematoma with History of Epidural Metastasis. Midwest Anesthesia Residents Conference, Chicago, IL, 2014.

Aggour K Baker-Watson NK. Anesthetic Management in the Parturient with Hypertrophic Obstructive Cardiomyopathy. Midwest Anesthesia Residents Conference, Cleveland, OH, May 2015.

Amiran S, Raskin A. Perioperative Management of Patient with Arrhythmogenic Right Ventricular Dysplasia. Midwest Anesthesia Residents Conference, Chicago, IL, 2014.

Augustin J, Presta M. Subperiosteal Hematoma Following Extubation from General Anesthesia. Midwest Anesthesia Residents Conference, Chicago, IL, 2014.

Banerjee N, Presta MV, Charous M, Gupta N. Fiscal Analysis of Implementing a Single Balloon Enteroscopy Program at a Tertiary Referral Center. Where Does the Revenue Come From? Digestive Disease Week, Washington, DC, 2015.

Bullough AS. OBstetric, Anesthesiology and Nursing (OBANN): Team Management of Obstetric Crises. CREOG and APGO Annual Meeting, San Antonio, TX, 2015.

Burcar KH, Mukherji J, Hood R. Diagnosis and Management of Post-Infarction Left Ventricular Free Wall Rupture. Midwest Anesthesia Residents Conference, Chicago, IL, 2014.

Burgart A, Mukherji J. Right Sided Aortic Arch, Aberrant Left Subclavian Artery, and Kommerell’s Diverticulum. Midwest Anesthesia Residents Conference, Chicago, IL, 2014.

Burgart A, Mukherji J. Right Sided Aortic Arch, Aberrant Left Subclavian Artery, and Kommerell’s Diverticulum. American Society of Anesthesiologists Annual Meeting, New Orleans, LA, 2014.

Byram S, Gupta RA, Ander M, Edelstein S, Andreatta B.. Effects of Continuous Octreotide Infusion on Intraoperative Transfusion Requirements during Orthotopic Liver Transplantation. American Society of Anesthesiology Annual Meeting, New Orleans, LA, 2014.

Charous M, Hartwig J, Byram S, Maniker M. Unusual Location of a Labor Epidural. American Society of Regional Anesthesia and Pain Medicine Spring Meeting, Chicago, IL, 2014.

Chavda A, Pawlowski J. Tracheal Intubation in the Prone Position Using An ILMA. Midwest Anesthesia Residents Conference, Chicago, IL, 2014.

Fierro MA, Sheikh T, Mukherji J. Intraoperative Transesophageal Echocardiography to Evaluate Acute Cessation of Venous Inflow during Cardiopulmonary Bypass. Midwest Anesthesia Residents Conference, Chicago, IL, 2014.

Frett MJ, Holtman JR, Jr. Pneumocephalus after lumbar epidural steroid injection. Midwest Anesthesia Residents Conference, Chicago, IL, April 2014.

Garcia D, Kwak J, LeVan P. Valve-in-Valve: Corevalve in Previous Bioprosthetic Aortic Valve. 2014 Society of Cardiovascular Anesthesiologists Annual Meeting, New Orleans, LA, 2014.

Gates K, Mukherji J, Gupta RA. The Role of Deep Hypothermic Circulatory Arrest in the Emergent Repair of a Leaking Descending Thoracic Aneurysm. Midwest Anesthesia Residents Conference, Chicago, IL, 2014.

Gates K, Mikhael M. Intracranial Foreign Body and the Pediatric Patient. Midwest Anesthesia Residents Conference, Cleveland, OH, May 2015.

Gumbrecht D, Buck T. Non-Traumatic Hip Pain in Patients with HIV Infection. Midwest Anesthesia Residents Conference, Cleveland, OH, May 2015.

Guzman B, LeVan P, Mukherji J. Iatrogenic Ischemic Coronary Lesion After Mitral Valve Replacement and MAZE. Midwest Anesthesia Residents Conference, Chicago, IL, 2014.

Guzman B, Mukherji J. Iatrogenic Ischemic Coronary Lesion After Mitral Valve Replacement and MAZE. American Society of Anesthesiologists Annual Meeting, New Orleans, LA, 2014.

Kamal S, Kwak J, Haske M, LeVan P. Left Ventricular Assist Device in Refractory Ventricular Tachycardia From Ischemic Cardiomyopthy. Society of Cardiovascular Anesthesiologists Annual Meeting, Washington, DC, 2015.

Kim K, Skene B. Anesthetic Management for Cesarean Delivery in a Parturient with Severe Cardiomyopathy: A Case Report. Society for Obstetric Anesthesia and Perinatology (SOAP) Annual Meeting, Toronto, Canada, 2014.

Maniker R, Charous M, Wilhelm A. Addition of Long-Acting Mid-Thigh Sciatic Block To Short-Acting Distal Popliteal Sciatic Block Provides Fast Onset and Prolonged Duration. American Society of Regional Anesthesia and Pain Medicine Spring Meeting, Chicago, IL, 2014.

Mehta NA, Raghavendra M. Fasciculations After Cervical Epidural Steroid Injection. Midwest Anesthesia Residents Conference, Chicago, IL, 2014.

Mehta NA, Ural N, Mukherji J. Inadvertent Placement of Cannula in Right Ventricle During Venoarterial Extracorporeal Membrane Oxygenation (VA-ECMO). Midwest Anesthesia Residents Conference, Cleveland, OH, May 2015.

Mikhael M, Rampersad S. “Management of Increased ICP” Clinical Events Checklist, produced by the Quality and Safety Committee of the Society for Pediatric Anesthesia (SPA), 2014.

Mikhael M. Propofol Can Induce Acute Exacerbation of FPIES (Food Protein-induced Enterocolitis Syndrome). SPA/AAP Pediatric Anesthesiology Meeting, Phoenix, AZ, 2015.

Mikhael M. Large Atelectasis Can Develop Within Few Minutes. SPA/AAP Pediatric Anesthesiology Meeting, Phoenix, AZ, 2015.

Mukherji J, Mehta N, Jellish WS. Unexplained Metabolic Acidosis with Fatality in a Critically Ill Patient Receiving A Low Dose Propofol Infusion. International Anesthesia Research Society Meeting, Honolulu, HI, 2015.

Naamo JJ, Bullough AS. CML: A New Contraindication for Neuraxial Anesthesia In Pregnancy. Midwest Anesthesia Residents Conference, Cleveland, OH, May 2015.

Naamo JJ, Mukherji J, Ander MR. Intraoperative Pea Arrest in the Setting of Hemochromatosis. Midwest Anesthesia Residents Conference, Cleveland, OH, May 2015.

Naamo JJ, Bullough AS. An Unusual Cause of Airway Obstruction. Midwest Anesthesia Residents Conference, Chicago, IL, 2014.

Nelson JH, LeVan P. Adult Morgagni Diaphragmatic Hernia Repair. Midwest Anesthesia Residents Conference, Chicago, IL, 2014.

Nelson JH, Oana S, Hamida A. Cocaine Testing: Urine, Blood, or Both? Midwest Anesthesia Residents Conference, Chicago, IL, 2014.

Nini S, Bullough AS. An Unusual Airway Foreign Body. Midwest Anesthesia Residents Conference, Chicago, IL, 2014.

Nini S, Mukherji J, Forsythe S. Evaluation of Postoperative Pulmonary Function of Cystic Fibrosis in the Intensive Care Following Lung Transplantation. Midwest Anesthesia Residents Conference, Chicago, IL, 2014.

Nini S, Mukherji J. Evaluation of Postoperative Pulmonary Function of Cystic Fibrosis in the Intensive Care Following Lung Transplantation. American Society of Anesthesiologists Annual Meeting, New Orleans, LA, 2014.

Oftadeh M, Kwak J, LeVan P. Left Atrial Appendage Laceration During Percutaneous Left Atrial Appendage Suture Ligation Using the LARIAT Device. Society of Cardiovascular Anesthesiologists Annual Meeting, Washington, DC, 2015. Oral presentation.

Oftadeh M, Sheikh T, Mehta N, LeVan P. Pulmonary Artery Aneurysm Involving the Main and Left PA in a Patient with Pulmonic Stenosis. Society of Cardiovascular Anesthesiologists Annual Meeting, Washington, DC, 2015.

Oftadeh M, Hood R. Anesthetic Management of a Heart Failure Patient Undergoing Angiography with Cardio help Support. Midwest Anesthesia Residents Conference, Cleveland, OH, May 2015.

Oftadeh M, Mukherji J, Levan P, Haske M. Percutaneous Mitral Valve Repair in a Patient with Severe Pulmonary Hypertension. Midwest Anesthesia Residents Conference, Cleveland, OH, May 2015.

O’Rourke MJ. Perioperative Care of an Elderly Patient on Apixaban Who Presents with Femur Fracture. Perioperative Medicine Summit, Scottsdale, AZ, 2015.

O’Rourke M, Byram S. Rate of Falls in Patients with Bilateral Femoral Nerve Catheter Placement for Pain Control After Bilateral Total Knew Arthroplasty. American Society of Regional Anesthesia and Pain Medicine Spring Meeting, Chicago, IL, 2014.

O’Rourke M, Kwak J. Preoperative Assessment of a Medically Complex Patient with Severe Pulmonary Hypertension. Perioperative Medicine Summit, Scottsdale, AZ, 2014.

Patel M, Mukherji J, Sheikh T. Ventricular Fibrillation/Arrest in the Post-Op Period from Inadvertent Asynchronous Pacing with Temporary Epicardial Leads: A Concern For Patient Safety. Midwest Anesthesia Residents Conference, Cleveland, OH, May 2015.

Patel P, Bullough AS. Anesthesia after Polio: New Concerns for an Old Disease. Midwest Anesthesia Residents Conference, Chicago, IL, 2014.

Schmelzle J, Kwak J, LeVan P. Hypoxemia Requiring PFO Closure and ECMO as a Bridge to Lung Transplantation. Midwest Anesthesia Residents Conference, Chicago, IL, 2014.

Schmelzle JM, LeVan P, Kwak J. Hypoxemia Requiring Patent Foramen Ovale Closure and Extra-corporeal Membrane Oxygenation as a Bridge to Bilateral Lung Transplantation. Society of Cardiovascular Anesthesiologists Annual Meeting, New Orleans, LA, 2014.

Sutton E, Byram S, O’Rourke M, Charous M. A Comparison of Transverse In Plane and Sagittal In Plane Approaches for Untracound Guided Fascia Iliaca Block. American Society of Regional Anesthesia and Pain Medicine Spring Meeting, Chicago, IL, 2014.

Sutton E, Pietrzak A. Indigo Carmine-Induced Hypotension in a Parturient with hypertrophic Cardiomyopathy and LAD Myocardial Bridging. American Society of Anesthesiologists Annual Meeting, New Orleans, LA, 2014.

Takabayashi K, Avramov MN. Unexpected Hypotension during Spine Surgery in a Patient with Unknown Dynamic Left Ventricular Outflow Tract Obstruction. American Society of Anesthesiologists Annual Meeting, New Orleans, LA, 2014.

Thakkar S, Mikat-Stevens M. Emergency Bronchoscopy in an Infant with Undiagnosed Critical Cardiac Disease. Midwest Anesthesia Residents Conference, Cleveland, OH, May 2015.

Thakkar S, Mukherji J, Kwak J. Emergent Pulmonary Thromboembolectomy For Saddle Embolus. Midwest Anesthesia Residents Conference, Cleveland, OH, May 2015.

Torchinova I, Kim K. Neuraxial Anesthesia for Cesarean Delivery in a Parturient with Marfan’s Syndrome and Dilated Aortic Root: A Case Report. Midwest Anesthesia Residents Conference, Chicago, IL, 2014.

Vincifora C, Avramov MN. Pseudocholynesterase Deficiency in a Patient Undergoing Ear Surgery with Facial Nerve Electromyograhy Monitoring. Midwest Anesthesia Residents Conference, Chicago, IL, 2014.

Vincifora C, Pietrzak A. Epidural Anesthesia for a Cesearean in a Patient with Bruganda Syndrome. American Society of Anesthesiologists Annual Meeting, New Orleans, LA, 2014.

Voronov M, Gupta RA, Mukherji J. Post-Intubation Tracheal Stenosis. Midwest Anesthesia Residents Conference, Chicago, IL, April 2014.

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Book Chapters

Ahmad F. Aesthetic Surgery. In: Practical Ambulatory Anesthesia 2014. Cambridge University Press, Cambridge, UK. (In press)

Ahmad F. Pediatric Ambulatory Surgery Anesthesia. In: Practical Ambulatory Anesthesia 2014. Cambridge University Press, Cambridge, UK. (In press)

Ahmad F. Management of Malignant Hyperthermia and Other Emergencies Office Based Setting. In: Practical Ambulatory Anesthesia 2014. Cambridge University Press, Cambridge, UK. (In press)

Francois A. Organization of Ambulatory Surgery Anesthesia in “Practical Ambulatory Anesthesia” 2nd edition. Richard Urman, Johan Raeder. Cambridge University Press. (In press)

Jellish WS, Edelstein S. “Neuroanesthesiology.” In: Neurologic Aspects of Systemic Disease. Eds. Biller J, Ferro JM. Volume 121, Part III, Elsevier B.V., Amsterdam, The Netherlands, 2014; 1623-1633.

Jellish W, Edelstein S, (2014). Spinal Anesthesia for Lower Level Spine Surgery, Topics in Spinal Anaesthesia, Dr. Víctor Whizar-Lugo (Ed.), ISBN: 978-953-51-1720-9, InTech Europe, DOI: 10.5772/58752. Available from: http://www.intechopen.com/books/topics-in-spinal-anaesthesia/spinal-anes....

Jellish WS, Loo J. Neurophysiologic Monitoring for Vestibular Schwannoma Chapter 27 In: Intraoperative Neuromonitoring. Eds. Loftus C, Biller J, Baron E. McGraw-Hill Education New York, NY. 2014.

Jellish WS, Khan T. Neurophysiologic Monitoring in Non-Neurosurgical Procedures Chapter 44 In: Intraoperative Neuromonitoring. Eds. Loftus C, Biller J, Baron E. McGraw–Hill Education New York, NY. 2014.

Oana S, Mukherji J. Acute and Chronic Respiratory Failure. [Review]. Handbook of Clinical Neurology. 119:273-88, 2014.

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