Publications

Clementz, M. A., Chen, Z., Banach, B. S., Wang, Y., Sun, L., Ratia, K., Baez-Santos, Y. M., Wang, J., Takayama, J., Ghosh, A. K., Li, K., Mesecar, A. D., Baker, S. C., 2010. Deubiquitinating and interferon antagonism activities of coronavirus papain-like proteases. J Virol. 84, 4619-29.

Sun, L., Xing, Y., Chen, X., Zheng, Y., Yang, Y., Nichols, D. B., Clementz, M. A., Banach, B. S., Li, K., Baker, S. C., Chen, Z., 2012. Coronavirus papain-like proteases negatively regulate antiviral innate immune response through disruption of STING-mediated signaling. PLoS One. 7, e30802.

Birch, N. W., Zeleznik-Le, N. J., 2010. Glycogen synthase kinase-3 and leukemia: restoring the balance. Cancer Cell. 17, 529-31.

Brubaker, A. L., Palmer, J. L., Kovacs, E. J., 2011a. Age-related Dysregulation of Inflammation and Innate Immunity: Lessons Learned from Rodent Models. Aging Dis. 2, 346-60.

Brubaker, A. L., Rendon, J. L., Ramirez, L., Choudhry, M. A., Kovacs, E. J., 2013. Reduced neutrophil chemotaxis and infiltration contributes to delayed resolution of cutaneous wound infection with advanced age. J Immunol. 190, 1746-57.

Brubaker, A. L., Schneider, D. F., Kovacs, E. J., 2011b. Neutrophils and natural killer T cells as negative regulators of wound healing. Expert Rev Dermatol. 6, 5-8.

Brubaker, A. L., Schneider, D. F., Palmer, J. L., Faunce, D. E., Kovacs, E. J., 2011c. An improved cell isolation method for flow cytometric and functional analyses of cutaneous wound leukocytes. J Immunol Methods. 373, 161-6.

Jeske, W. P., Walenga, J. M., Hoppensteadt, D. A., Vandenberg, C., Brubaker, A., Adiguzel, C., Bakhos, M., Fareed, J., 2008. Differentiating low-molecular-weight heparins based on chemical, biological, and pharmacologic properties: implications for the development of generic versions of low-molecular-weight heparins. Semin Thromb Hemost. 34, 74-85.

Mahbub, S., Brubaker, A. L., Kovacs, E. J., 2011. Aging of the Innate Immune System: An Update. Curr Immunol Rev. 7, 104-115.

Chen, M. M., Bird, M. D., Zahs, A., Deburghgraeve, C., Posnik, B., Davis, C. S., Kovacs, E. J., 2013. Pulmonary inflammation after ethanol exposure and burn injury is attenuated in the absence of IL-6. Alcohol.

Ostler, K. R., Yang, Q., Looney, T. J., Zhang, L., Vasanthakumar, A., Tian, Y., Kocherginsky, M., Raimondi, S. L., DeMaio, J. G., Salwen, H. R., Gu, S., Chlenski, A., Naranjo, A., Gill, A., Peddinti, R., Lahn, B. T., Cohn, S. L., Godley, L. A., 2012. Truncated DNMT3B isoform DNMT3B7 suppresses growth, induces differentiation, and alters DNA methylation in human neuroblastoma. Cancer Res. 72, 4714-23.

Yadav, V., Yanez, N. C., Fenton, S. E., Denning, M. F., 2010. Loss of protein kinase C delta gene expression in human squamous cell carcinomas: a laser capture microdissection study. Am J Pathol. 176, 1091-6.
Iqbal, O., Fisher, G., Vira, S., Syed, D., Sadeghi, N., Freeman, D., Campbell, E., Sugar, J., Feder, R., Fareed, J., Bouchard, C., 2013. Increased Expression of Secreted Frizzled-Related Protein-1 and Microtubule-Associated Protein Light Chain 3 in Keratoconus. Cornea.

Gillani, R. L., Tsai, S. Y., Wallace, D. G., O'Brien, T. E., Arhebamen, E., Tole, M., Schwab, M. E., Kartje, G. L., 2010. Cognitive recovery in the aged rat after stroke and anti-Nogo-A immunotherapy. Behav Brain Res. 208, 415-24.

Heald-Sargent, T., Gallagher, T., 2012. Ready, set, fuse! The coronavirus spike protein and acquisition of fusion competence. Viruses. 4, 557-80.

Shah, S., Lowery, E., Braun, R. K., Martin, A., Huang, N., Medina, M., Sethupathi, P., Seki, Y., Takami, M., Byrne, K., Wigfield, C., Love, R. B., Iwashima, M., 2012. Cellular basis of tissue regeneration by omentum. PLoS One. 7, e38368.

Burgette, R. C., Benscoter, B. J., Monaco, G. N., Kircher, M. L., Mantravadi, A. V., Marzo, S. J., Jones, K. J., Foecking, E. M., 2011. A Rat Model for Intracranial Facial Nerve Crush Injuries. Otolaryngol Head Neck Surg.

Gomez, C. R., Hirano, S., Cutro, B. T., Birjandi, S., Baila, H., Nomellini, V., Kovacs, E. J., 2007. Advanced age exacerbates the pulmonary inflammatory response after lipopolysaccharide exposure. Crit Care Med. 35, 246-51.

Gomez, C. R., Karavitis, J., Palmer, J. L., Faunce, D. E., Ramirez, L., Nomellini, V., Kovacs, E. J., 2010. Interleukin-6 contributes to age-related alteration of cytokine production by macrophages. Mediators Inflamm. 2010, 475139.

Gomez, C. R., Nomellini, V., Baila, H., Oshima, K., Kovacs, E. J., 2009. Comparison of the effects of aging and IL-6 on the hepatic inflammatory response in two models of systemic injury: scald injury versus i.p. LPS administration. Shock. 31, 178-84.

Gomez, C. R., Nomellini, V., Faunce, D. E., Kovacs, E. J., 2008. Innate immunity and aging. Exp Gerontol. 43, 718-28.

Nomellini, V., Faunce, D. E., Gomez, C. R., Kovacs, E. J., 2008a. An age-associated increase in pulmonary inflammation after burn injury is abrogated by CXCR2 inhibition. J Leukoc Biol. 83, 1493-501.

Nomellini, V., Gomez, C. R., Gamelli, R. L., Kovacs, E. J., 2009. Aging and animal models of systemic insult: trauma, burn, and sepsis. Shock. 31, 11-20.

Nomellini, V., Gomez, C. R., Kovacs, E. J., 2008b. Aging and impairment of innate immunity. Contrib Microbiol. 15, 188-205.

Li, X., Rendon, J. L., Akhtar, S., Choudhry, M. A., 2012. Activation of toll-like receptor 2 prevents suppression of T-cell interferon gamma production by modulating p38/extracellular signal-regulated kinase pathways following alcohol and burn injury. Mol Med. 18, 982-91.

Rendon, J. L., Choudhry, M. A., 2012. Th17 cells: critical mediators of host responses to burn injury and sepsis. J Leukoc Biol. 92, 529-38.

Rendon, J. L., Janda, B. A., Bianco, M. E., Choudhry, M. A., 2012. Ethanol exposure suppresses bone marrow-derived dendritic cell inflammatory responses independent of TLR4 expression. J Interferon Cytokine Res. 32, 416-25.

Rendon, J. L., Li, X., Akhtar, S., Choudhry, M. A., 2013. Interleukin-22 modulates gut epithelial and immune barrier functions following acute alcohol exposure and burn injury. Shock. 39, 11-8.


Invited Presentations

Birch, N.W. and Zeleznik-Le, N.J.:  Identification of critical residues within MLL fusion proteins that contribute to leukemia development.  (Poster presentation) Joint Meeting of the American Society for Clinical Investigation and the Association of American Physicians: Chicago, IL (28 April 2012)

Brubaker A.L. and Kovacs EJ.: (Poster Presentation) Increased bacterial colonization in aged mice is associated with delayed b-defensin induction. Nathan Shock Center Conference on Aging: San Antonio, TX (2011)

Brubaker, A.L,, Rendon JR, Choudhry MA and Kovacs EJ.: Increased bacterial colonization and delayed wound closure in aged mice is associated with altered leukocyte recruitment. (Poster Presentation) American Association of Immunologists: Boston, MA (2012)

Fenton, S., Denning, M.: Regulation and Targeting of Fyn in Cutaneous Squamous Cell Carcinoma.  (Poster presentation) American Association for Cancer Research: Chicago, IL (2012)

Freeman D., Leukam M., Campbell E.: TRIM2 and TRIM9 ubiquitin ligases in cellular models of neurodegenerative disease: Intracellular dynamics and interactions with alpha-synuclein.  (Poster presentation) Society for Neuroscience, Washington DC (November 2011)

Huang, N., Medina, M., Sethupathi, P., Martin, A., Dewey, A., Wafai, R., Wigfield, C., Iwashima, M., Love, R.B.: Treatment with Omental Cells Reduces Acute Inflammation in an Allogenic Lung Transplantation Model.  (Poster presentation)  American Thoracic Society: San Francisco, CA (2012)

Podraza, K.M, Gillani, R., Sharma, N.,, Origitano, T.C, Khaldi, A., Schneck, M.J.:. Factors influencing the management of unruptured intracranial aneurysms.   (Poster presentation) International Neurocritical Conference: Montreal, Canada (September 2011)

Rendon, J.L.: The role of aryl hydrocarbon receptor in IL-23 dependent release of IL-22 following ethanol exposure and burn injury.  (Oral presentation) Society for Leukocyte Biology.  Kansas City, MO (September 2011)

Rendon, J.L.: IL-22 modulates gut epithelial and immune barrier functions following acute alcohol intoxication and burn injury.  (Oral presentation) Annual Conference on Shock.  Miami Beach, FL (June 2012)

Rendon, J.L., Janda, B.A., Li, X., Choudhry, M.A.: Acute alcohol intoxication suppresses expression of gut antimicrobial peptides Reg3β and Reg3γ following burn injury. (Poster presentation) Research Society on Alcoholism: San Francisco, CA (June 2012)


Individual Training Grants

Ruth L. Kirschstein National Research Service Awards:

Birch, N.  (Zeleznik-Le, N., mentor) National Heart Lung and Blood Institute F30 HL103280.  7/2/2010-7/1/2013
Jaeger, K. (Iwashima, M., mentor) National Institute on Alcohol Abuse and Alcoholism.  F30 AA021323.  4/1/2012-3/31/2016
Rendon, J. (Choudhry M., mentor) National Institute on Alcohol Abuse and Alcoholism.  F30 AA021323.  3/1/2011-2/28/2015