Program for Experimental and Theoretical Modeling (PETM)

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Selected research projects:

1. Characterization and modeling of intracellular and extracellular hepatitis C virus (HCV) inhibition kinetics during in    vitro HCV infection and treatment with direct-acting agents (DAAs)


2. Quantification of HCV cell-to-cell spread using stochastic and agent based modeling approaches.


3. Understating the role of the liver in HCV clearance.


4. Predicting cure boundary/treatment duration necessary for cure while patients are undergoing DAA therapy.


5. Conducting clinical trials to analyzing and modeling the effect of HCV entry/spread inhibitor ezetimibe.


6. Modeling HCV prevalence, transmission, treatment scale up and HCV vaccine trial design in persons who inject drugs.


7. Understanding HBV infection and treatment in vitro, small animals and patients.


8. Understanding hepatitis Delta virus (HDV) infection and treatment in vitro, small animal models and patients.


9. Analysis and modeling of hepatitis E virus (HEV) kinetics and during infection and treatment.