- Profile Image
- Name
- Scott Cotler
- Degree
- M.D.
- Rank
- Professor
- Primary Department
- Medicine
- Education
- Medical School
- University of Chicago Pritzker School of Medicine
- Residencies
- University of Chicago Medical Center Internal Medicine: General
- Fellowships
- Rush-Presbyterian-St. Luke's Medical Center Internal Medicine: Gastroenterology
- University of Washington Medical Center Internal Medicine: Hepatology
- Publications
- Shekhtman, L; Cotler, SJ; Degasperi, E; Anolli, MP; Uceda Renteria, SC; Sambarino, D; Borghi, M; Perbellini, R; Facchetti, F; Ceriotti, F; Lampertico, P; Dahari, H Modelling HDV kinetics under the entry inhibitor bulevirtide suggests the existence of two HDV-infected cell populations. JHEP reports : innovation in hepatology ; 6 2
- Mosenthal, M; Adams, W; Cotler, S; Ding, X; Borge, M; Malamis, A; Lee, D; Thomas, T; Jawahar, A; Amin, P; Molvar, C Locoregional Therapies of Hepatocellular Carcinoma Prior to Liver Transplant: Comparative Pathologic Necrosis, Radiologic Response, and Recurrence. Journal of vascular and interventional radiology : JVIR ;
- deBettencourt, MF; Liu, Y; Cotler, SJ; Molvar, CA; Abdelrahman, T; Thomas, TO SBRT vs. Y90: HCC Treatment Outcomes and Costs. American Journal of Clinical Oncology ;
- Shekhtman, L; Duehren, S; Etzion, O; Cotler, SJ; Dahari, H Hepatitis D Virus and HBsAg Dynamics in the era of new Antiviral Treatments. Current gastroenterology reports ;
- Elkady, D; Okorie, CL; Estupiñan, B; Modi, MB; Cotler, SJ; Lake, E A diagnostic challenge: Life-threatening drug reaction with eosinophilia and systemic symptoms in the setting of a SARS-CoV-2 and human herpesvirus-6 reactivation in a patient with severe hepatic injury on bupropion. JAAD case reports ; 39
- Prasad Venkatesulu, B; Ness, E; Ross, D; Saripalli, AL; Abood, G; Badami, A; Cotler, S; Dhanarajan, A; Knab, LM; Lee, B; Molvar, C; Sethi, A; Small, W; Refaat, T MRI-guided Real-time Online Gated Stereotactic Body Radiation Therapy for Liver Tumors. American Journal of Clinical Oncology ;
- Hershkovich, L; Shekhtman, L; Bazinet, M; Pântea, V; Placinta, G; Cotler, SJ; Vaillant, A; Dahari, H Rapid monophasic HBsAg decline during nucleic-acid polymer-based therapy predicts functional cure. Hepatology communications ; 7 8
- Malnassy, G; Keating, CR; Gad, S; Bridgeman, B; Perera, A; Hou, W; Cotler, SJ; Ding, X; Choudhry, M; Sun, Z; Koleske, AJ; Qiu, W Inhibition of Abelson Tyrosine-Protein Kinase 2 Suppresses the Development of Alcohol-Associated Liver Disease by Decreasing PPARgamma Expression. Cellular and molecular gastroenterology and hepatology ;
- Etzion, O; Hamid, S; Lurie, Y; Gane, EJ; Yardeni, D; Duehren, S; Bader, N; Nevo-Shor, A; Channa, SM; Cotler, SJ; Mawani, M; Parkash, O; Dahari, H; Ingrid, C; Glenn, J Treatment of chronic hepatitis d with peginterferon lambda - the phase 2 LIMT-1 clinical trial. Hepatology (Baltimore, Md.) ;
- Kushner, T; Nyabanga, CT; Cotler, SJ; Etzion, O; Dahari, H Modeling-Based Response-Guided Hepatitis C Treatment During Pregnancy and Postpartum. Open forum infectious diseases ; 10 2
- Mhlanga, A; Zakh, R; Churkin, A; Reinharz, V; Glenn, JS; Etzion, O; Cotler, SJ; Yurdaydin, C; Barash, D; Dahari, H Modeling the Interplay between HDV and HBV in Chronic HDV/HBV Patients. Mathematics (Basel, Switzerland) ; 10 20
- Goyal, A; Churkin, A; Barash, D; Cotler, SJ; Shlomai, A; Etzion, O; Dahari, H Modeling-Based Response-Guided DAA Therapy for Chronic Hepatitis C to Identify Individuals for Shortening Treatment Duration. Open forum infectious diseases ; 9 5
- Hou, W; Bridgeman, B; Malnassy, G; Ding, X; Cotler, SJ; Dhanarajan, A; Qiu, W Integrin subunit beta 8 contributes to lenvatinib resistance in HCC. Hepatology communications ;
- Tatara, E; Gutfraind, A; Collier, NT; Echevarria, D; Cotler, SJ; Major, ME; Ozik, J; Dahari, H; Boodram, B Modeling hepatitis C micro-elimination among people who inject drugs with direct-acting antivirals in metropolitan Chicago. PLoS ONE ; 17 3
- Shekhtman, L; Cotler, SJ; Ploss, A; Dahari, H Mathematical modeling suggests that entry-inhibitor Bulevirtide may interfere with hepatitis D virus clearance from circulation. Journal of Hepatology ;
- Zakh, R; Churkin, A; Bietsch, W; Lachiany, M; Cotler, SJ; Ploss, A; Dahari, H; Barash, D A Mathematical Model for early HBV and -HDV Kinetics during Anti-HDV Treatment. Mathematics (Basel, Switzerland) ; 9 24
- Churkin, A; Kriss, S; Uziel, A; Goyal, A; Zakh, R; Cotler, SJ; Etzion, O; Shlomai, A; Rotstein, HG; Dahari, H; Barash, D Machine learning for mathematical models of HCV kinetics during antiviral therapy. Mathematical biosciences ;
- Shekhtman, L; Navasa, M; Sansone, N; Crespo, G; Subramanya, G; Chung, TL; Cardozo-Ojeda, EF; Pérez-Del-Pulgar, S; Perelson, AS; Cotler, SJ; Forns, X; Uprichard, SL; Dahari, H Modeling hepatitis C virus kinetics during liver transplantation reveals the role of the liver in virus clearance. eLife ; 10
- Missikpode, C; Kramer, H; Cotler, SJ; Durazo-Arvizu, R; Lash, JP; Kallwitz, E; Cai, J; Kuniholm, MH; Rosas, SE; Ricardo, AC; Talavera, GA; Raij, L; Pirzada, A; Daviglus, ML Association of elevated serum aminotransferase levels with chronic kidney disease measures: hispanic community health study/study of latinos. BMC Nephrology ; 22 1
- Singh, J; Wozniak, A; Cotler, SJ; Dhanarajan, A; Aldrich, D; Park, D; Kasia, C; Schmidt, B; Scaglione, S Combined Use of Aspirin and Statin is Associated With a Decreased Incidence of Hepatocellular Carcinoma. Journal of clinical gastroenterology ;
- Dahari, H; Shlomai, A; Cotler, SJ Early HBV RNA kinetics under NA treatment may reveal new insights into HBV RNA dynamics and NA mode of action-more detailed kinetic studies are needed. Journal of viral hepatitis ;
- Hua, S; Qi, Q; Kizer, JR; Williams-Nguyen, J; Strickler, HD; Thyagarajan, B; Daviglus, M; Talavera, GA; Schneiderman, N; Cotler, SJ; Cai, J; Kaplan, R; Isasi, CR Association of liver enzymes with incident diabetes in US Hispanic/Latino adults. Diabetic medicine : a journal of the British Diabetic Association ;
- Wang, H; Hou, W; Perera, A; Bettler, C; Beach, JR; Ding, X; Li, J; Denning, MF; Dhanarajan, A; Cotler, SJ; Joyce, C; Yin, J; Ahmed, F; Roberts, LR; Qiu, W Targeting EphA2 suppresses hepatocellular carcinoma initiation and progression by dual inhibition of JAK1/STAT3 and AKT signaling. Cell reports ; 34 8
- Dasgupta, Swikriti; Imamura, Michio; Gorstein, Evan; Nakahara, Takashi; Tsuge, Masataka; Churkin, Alexander; Yardeni, David; Etzion, Ohad; Uprichard, Susan L; Barash, Danny; Cotler, Scott J; Dahari, Harel; Chayama, Kazuaki Modeling-Based Response-Guided Glecaprevir-Pibrentasvir Therapy for Chronic Hepatitis C to Identify Patients for Ultrashort Treatment Duration. Journal of Infectious Diseases ; 222 7
- Etzion, O; Dahari, H; Yardeni, D; Issachar, A; Nevo-Shor, A; Cohen-Naftaly, M; Ashur, Y; Uprichard, SL; Arbib, OS; Munteanu, D; Braun, M; Cotler, SJ; Abufreha, N; Keren-Naus, A; Shemer-Avni, Y; Mor, O; Murad, J; Novack, V; Shlomai, A Response guided therapy for reducing duration of direct acting antivirals in chronic hepatitis C infected patients: a Pilot study. Scientific reports ; 10 1
- Dahari, H; Vaillant, A; Cotler, SJ Letter to the Editor: Examining HBV RNA kinetics during NA treatment - are NA multifunctional antiviral agents? Hepatology (Baltimore, Md.) ;
- Kallwitz, E; Tayo, BO; Kuniholm, MH; Daviglus, M; Zeng, D; Isasi, CR; Cotler, SJ Association of HSD17B13 rs72613567:TA with non-alcoholic fatty liver disease in Hispanics/Latinos. Liver international : official journal of the International Association for the Study of the Liver ; 40 4
- Wang, F; Hou, W; Chitsike, L; Xu, Y; Bettler, C; Perera, A; Bank, T; Cotler, SJ; Dhanarajan, A; Denning, MF; Ding, X; Breslin, P; Qiang, W; Li, J; Koleske, AJ; Qiu, W ABL1, Overexpressed in Hepatocellular Carcinomas, Regulates Expression of NOTCH1 and Promotes Development of Liver Tumors in Mice. Gastroenterology ; 159 1
- Dasgupta, S; Imamura, M; Gorstein, E; Nakahara, T; Tsuge, M; Churkin, A; Yardeni, D; Etzion, O; Uprichard, SL; Barash, D; Cotler, SJ; Dahari, H; Chayama, K Modeling-based response-guided therapy for chronic hepatitis C under glecaprevir/pibrentasvir may identify patients for ultra-short treatment duration. The Journal of infectious diseases ;
- Shekhtman, L; Cotler, SJ; Hershkovich, L; Uprichard, SL; Bazinet, M; Pantea, V; Cebotarescu, V; Cojuhari, L; Jimbei, P; Krawczyk, A; Dittmer, U; Vaillant, A; Dahari, H Modelling hepatitis D virus RNA and HBsAg dynamics during nucleic acid polymer monotherapy suggest rapid turnover of HBsAg. Scientific reports ; 10 1
- Li, J; Hua, S; Chen, GC; Strizich, G; Kuniholm, MH; Shan, Z; Talavera, GA; Castañeda, SF; Gellman, MD; Cai, J; Cotler, SJ; Zhang, X; Hu, FB; Kaplan, R; Isasi, CR; Qi, Q Objectively measured sedentary time, physical activity and liver enzyme elevations in US Hispanics/Latinos. Liver international : official journal of the International Association for the Study of the Liver ;
- Lee, DD; Cotler, SJ Finding the Right Balance for the Use of Donation After Circulatory Death Livers for Patients With Hepatocellular Carcinoma. Liver Transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society ;
- Gorstein, E; Martinello, M; Churkin, A; Dasgupta, S; Walsh, K; Applegate, TL; Yardeni, D; Etzion, O; Uprichard, SL; Barash, D; Cotler, SJ; Matthews, GV; Dahari, H Modeling based response guided therapy in subjects with recent hepatitis C infection. Antiviral Research ; 180
- Tatara, E; Collier, NT; Ozik, J; Gutfraind, A; Cotler, SJ; Dahari, H; Major, M; Boodram, B MULTI-OBJECTIVE MODEL EXPLORATION OF HEPATITIS C ELIMINATION IN AN AGENT-BASED MODEL OF PEOPLE WHO INJECT DRUGS. Proceedings of the ... Winter Simulation Conference. Winter Simulation Conference ; 2019
- Parrinello, Christina M.; Rudolph, Bryan J.; Lazo, Mariana; Gallo, Linda C.; Thyagarajan, Bharat; Cotler, Scott J.; Qi, Qibin; Seeherunvong, Tossaporn; Vidot, Denise C.; Strickler, Howard D.; Kaplan, Robert C.; Isasi, Carmen R. Associations of Insulin Resistance and Glycemia With Liver Enzymes in Hispanic/Latino Youths: Results From the Hispanic Community Children's Health Study/Study of Latino Youth (SOL Youth). Journal of clinical gastroenterology ; 53 2
- Shteyer, E; Shekhtman, L; Zinger, T; Harari, S; Gafanovich, I; Wolf, D; Ivgi, H; Barsuk, R; Dery, I; Armoni, D; Rivkin, M; Pipalia, R; Cohen Eliav, M; Skorochod, Y; Breuer, GS; Tur-Kaspa, R; Weil Wiener, Y; Stern, A; Cotler, SJ; Dahari, H; Lurie, Y Modeling suggests that microliter volumes of contaminated blood caused an outbreak of hepatitis C during computerized tomography. PLoS ONE ; 14 1
- Koh, C; Dubey, P; Han, MAT; Walter, PJ; Garraffo, HM; Surana, P; Southall, NT; Borochov, N; Uprichard, SL; Cotler, SJ; Etzion, O; Heller, T; Dahari, H; Liang, TJ A randomized, proof-of-concept clinical trial on repurposing chlorcyclizine for the treatment of chronic hepatitis C. Antiviral Research ; 163
- Kallwitz, ER; Tayo, BO; Kuniholm, MH; Cai, J; Daviglus, M; Cooper, RS; Cotler, SJ American Ancestry Is a Risk Factor for Suspected Nonalcoholic Fatty Liver Disease in Hispanic/Latino Adults. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association ; 17 11
- Echevarria, D; Gutfraind, A; Boodram, B; Layden, J; Ozik, J; Page, K; Cotler, SJ; Major, M; Dahari, H Modeling indicates efficient vaccine-based interventions for the elimination of hepatitis C virus among persons who inject drugs in metropolitan Chicago. Vaccine ; 37 19
- Malespin, M; Harris, C; Kanar, O; Jackman, K; Smotherman, C; Johnston, A; Ferm, J; de Melo, SW; Scolapio, JS; Nelson, DR; Cotler, SJ Barriers to treatment of chronic hepatitis C with direct acting antivirals in an urban clinic. Annals of hepatology ; 18 2
- Shang, N; Wang, H; Bank, T; Perera, A; Joyce, C; Kuffel, G; Zilliox, MJ; Cotler, SJ; Ding, X; Dhanarajan, A; Breslin, P; Qiu, W Focal Adhesion Kinase and ß-Catenin Cooperate to Induce Hepatocellular Carcinoma. Hepatology (Baltimore, Md.) ; 70 5
- Lhomme, S; DebRoy, S; Kamar, N; Abravanel, F; Metsu, D; Marion, O; Dimeglio, C; Cotler, SJ; Izopet, J; Dahari, H Plasma Hepatitis E Virus Kinetics in Solid Organ Transplant Patients Receiving Ribavirin. Viruses ; 11 7
- Gambato, M; Canini, L; Lens, S; Graw, F; Perpiñan, E; Londoño, MC; Uprichard, SL; Mariño, Z; Reverter, E; Bartres, C; González, P; Pla, A; Costa, J; Burra, P; Cotler, SJ; Forns, X; Dahari, H Early HCV viral kinetics under DAAs may optimize duration of therapy in patients with compensated cirrhosis. Liver international : official journal of the International Association for the Study of the Liver ; 39 5
- Loy, VM; Joyce, C; Bello, S; VonRoenn, N; Cotler, SJ Gender disparities in liver transplant candidates with nonalcoholic steatohepatitis. Clinical transplantation ;
- Wang, F; Bank, T; Malnassy, G; Arteaga, M; Shang, N; Dalheim, A; Ding, X; Cotler, SJ; Denning, MF; Nishimura, MI; Breslin, P; Qiu, W Inhibition of insulin-like growth factor 1 receptor enhances the efficacy of sorafenib in inhibiting hepatocellular carcinoma cell growth and survival. Hepatology communications ; 2 6
- Major, M; Gutfraind, A; Shekhtman, L; Cui, Q; Kachko, A; Cotler, SJ; Hajarizadeh, B; Sacks-Davis, R; Page, K; Boodram, B; Dahari, H Modeling of patient virus titers suggests that availability of a vaccine could reduce hepatitis C virus transmission among injecting drug users. Science translational medicine ; 10 449
- Venepalli, NK; Modayil, MV; Berg, SA; Nair, TD; Parepally, M; Rajaram, P; Gaba, RC; Bui, JT; Huang, Y; Cotler, SJ Features of hepatocellular carcinoma in Hispanics differ from African Americans and non-Hispanic Whites. WORLD JOURNAL OF HEPATOLOGY ; 9 7
- Malespin, M; Moore, CM; Fialho, A; de Melo, SW; Benyashvili, T; Kothari, AN; di Sabato, D; Kallwitz, ER; Cotler, SJ; Lu, AD Case Series of 10 Patients with Cirrhosis Undergoing Emergent Repair of Ruptured Umbilical Hernias: Natural History and Predictors of Outcomes. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation ;
- Duarte-Rojo, A; Fischer, SE; Adeyi, O; Zita, D; Deneke, MG; Selzner, N; Chen, L; Malespin, M; Cotler, SJ; McGilvray, ID; Feld, JJ Protease inhibitors partially overcome the interferon nonresponse phenotype in patients with chronic hepatitis C. Journal of viral hepatitis ; 23 5
- Cellar, DF; Voster, D; Fetters, R; Twitchell, E; Harper, GW; Scott, C Personality, Coping, and Well-Being for People Living with Chronic Hepatitis C. Psychological reports ; 118 2
- Canini, L; DebRoy, S; Mariño, Z; Conway, JM; Crespo, G; Navasa, M; D'Amato, M; Ferenci, P; Cotler, SJ; Forns, X; Perelson, AS; Dahari, H Severity of liver disease affects HCV kinetics in patients treated with intravenous silibinin monotherapy. ANTIVIRAL THERAPY ; 20 2
- Guedj, J; Canini, L; Cotler, S; Dahari, H Reply: To PMID 25098971. Hepatology (Baltimore, Md.) ; 61 6
- Gaba, RC; Kallwitz, ER; Parvinian, A; Bui, JT; Von Roenn, NM; Berkes, JL; Cotler, SJ Imaging surveillance and multidisciplinary review improves curative therapy access and survival in HCC patients. Annals of hepatology ; 12 5
- Sun, S; Song, Z; Cotler, SJ; Cho, M Biomechanics and functionality of hepatocytes in liver cirrhosis. Journal of Biomechanics ; 47 9
- Kuniholm, MH; Jung, M; Everhart, JE; Cotler, S; Heiss, G; McQuillan, G; Kim, RS; Strickler, HD; Thyagarajan, B; Youngblood, M; Kaplan, RC; Ho, GY Prevalence of hepatitis C virus infection in US Hispanic/Latino adults: results from the NHANES 2007-2010 and HCHS/SOL studies. The Journal of infectious diseases ; 209 10
- Goyal, L; Supko, JG; Berlin, J; Blaszkowsky, LS; Carpenter, A; Heuman, DM; Hilderbrand, SL; Stuart, KE; Cotler, S; Senzer, NN; Chan, E; Berg, CL; Clark, JW; Hezel, AF; Ryan, DP; Zhu, AX Phase 1 study of N(1),N(11)-diethylnorspermine (DENSPM) in patients with advanced hepatocellular carcinoma. CANCER CHEMOTHERAPY AND PHARMACOLOGY ; 72 6