Profile Image
Charles Hemenway Photo
Charles Hemenway
Primary Department
Pediatric Hematology/Oncology
Appointment Request
Request an Appointment
Cancer in Children and Adolescents
Bleeding Disorders in Children and Adolescents
Anemia in Children and Adolescents
Loyola Center for Health at Homer Glen
Ronald McDonald ® Children's Hospital
Loyola Outpatient Center
American Board of Pediatrics Subspecialty Pediatric Hematology & Oncology
Advanced Degrees
Duke University , Durham , NC , United States
Medical School
University of Massachusetts Medical School
University of Florida, Internal Medicine & Pediatrics
Duke University Medical Center, Pediatrics: Pediatric Hematology-Oncology
Kuntimaddi,A.; Achille,N. J.; Thorpe,J.; Lokken,A. A.; Singh,R.; Hemenway,C. S.; Adli,M.; Zeleznik-Le,N. J.; Bushweller,J. H.Degree of Recruitment of DOT1L to MLL-AF9 Defines Level of H3K79 Di- and Tri-methylation on Target Genes and Transformation Potential Cell reports 2015 ;11(5):808-820
Barretto,N. N.; Karahalios,D. S.; You,D.; Hemenway,C. S.An AF9/ENL-targted peptide with therapeutic potential in mixed lineage leukemias Journal of experimental therapeutics & oncology 2014 ;10(4):293-300
Lokken,A. A.; Achille,N. J.; Chang,M. J.; Lin,J. J.; Kuntimaddi,A.; Leach,B. I.; Malik,B.; Nesbit,J. B.; Zhang,S.; Bushweller,J. H.; Zeleznik-Le,N. J.; Hemenway,C. S.Importance of a specific amino acid pairing for murine MLL leukemias driven by MLLT1/3 or AFF1/4 Leukemia research 2014 ;38(11):1309-1315
Malik,B.; Hemenway,C. S.CBX8, a component of the Polycomb PRC1 complex, modulates DOT1L-mediated gene expression through AF9/MLLT3 FEBS letters 2013 ;587(18):3038-3044
Chang,M. J.; Wu,H.; Achille,N. J.; Reisenauer,M. R.; Chou,C. W.; Zeleznik-Le,N. J.; Hemenway,C. S.; Zhang,W.Histone H3 lysine 79 methyltransferase Dot1 is required for immortalization by MLL oncogenes Cancer research 2010 ;70(24):10234-10242
Lin,J. J.; Hemenway,C. S.Hsp90 directly modulates the spatial distribution of AF9/MLLT3 and affects target gene expression. Journal of Biological Chemistry 2010 ;285(16):11966-11973
Bennett,C. A.; Winters,A. C.; Barretto,N. N.; Hemenway,C. S.Molecular targeting of MLL-rearranged leukemia cell lines with the synthetic peptide PFWT synergistically enhances the cytotoxic effect of established chemotherapeutic agents. Leukemia research 2009 ;33(7):937-947
Palermo,C. M.; Bennett,C. A.; Winters,A. C.; Hemenway,C. S.The AF4-mimetic peptide, PFWT, induces necrotic cell death in MV4-11 leukemia cells. Leukemia research 2008 ;32(4):633-642
Karras,N. A.; Hemenway,C. S.Hurricane Katrina's impact on pediatric and adult patients with sickle cell disease. Journal of Health Care for the Poor & Underserved 2007 ;18(2):382-393
Zhang,W.; Xia,X.; Reisenauer,M. R.; Hemenway,C. S.; Kone,B. C.Dot1a-AF9 complex mediates histone H3 Lys-79 hypermethylation and repression of ENaCalpha in an aldosterone-sensitive manner. Journal of Biological Chemistry 2006 ;281(26):18059-18068
Reiser,J.; Zhang,X. Y.; Hemenway,C. S.; Mondal,D.; Pradhan,L.; La Russa,V. F.Potential of mesenchymal stem cells in gene therapy approaches for inherited and acquired diseases Expert Opinion on Biological Therapy 2005 ;5(12):1571-1584
Erfurth,F.; Hemenway,C. S.; de Erkenez,A. C.; Domer,P. H.MLL fusion partners AF4 and AF9 interact at subnuclear foci Leukemia 2004 ;18(1):92-102
Srinivasan,R. S.; Nesbit,J. B.; Marrero,L.; Erfurth,F.; LaRussa,V. F.; Hemenway,C. S.The synthetic peptide PFWT disrupts AF4-AF9 protein complexes and induces apoptosis in t(4;11) leukemia cells Leukemia 2004 ;18(8):1364-1372
Srinivasan,R. S.; de Erkenez,A. C.; Hemenway,C. S.The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor Oncogene 2003 ;22(22):3395-3406
Hemenway,C. S.; de Erkenez,A. C.; Gould,G. C.The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias Oncogene 2001 ;20(29):3798-3805
Hemenway,C. S.; Halligan,B. W.; Gould,G. C.; Levy,L. S.Identification and analysis of a third mouse Polycomb gene, MPc3 Gene 2000 ;242(1-2):31-40