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Michael Nishimura
Primary Department
Surgical Research
Advanced Degrees
University of Maryland, Baltimore County , Baltimore , MD , United States
Gene Therapy
Foley,K. C.; Spear,T. T.; Murray,D. C.; Nagato,K.; Garrett-Mayer,E.; Nishimura,M. I.HCV T Cell Receptor Chain Modifications to Enhance Expression, Pairing, and Antigen Recognition in T Cells for Adoptive Transfer Molecular therapy oncolytics 2017 ;5:105-115
Lovgren,T.; Sarhan,D.; Truxova,I.; Choudhary,B.; Maas,R.; Melief,J.; Nystrom,M.; Edback,U.; Vermeij,R.; Scurti,G.; Nishimura,M.; Masucci,G.; Karlsson-Parra,A.; Lundqvist,A.; Adamson,L.; Kiessling,R.Enhanced stimulation of human tumor-specific T cells by dendritic cells matured in the presence of interferon-gamma and multiple toll-like receptor agonists Cancer immunology, immunotherapy : CII 2017 ; :
Wang,Y.; Singh,N. K.; Spear,T. T.; Hellman,L. M.; Piepenbrink,K. H.; McMahan,R. H.; Rosen,H. R.; Vander Kooi,C. W.; Nishimura,M. I.; Baker,B. M.How an alloreactive T-cell receptor achieves peptide and MHC specificity Proceedings of the National Academy of Sciences of the United States of America 2017 ;114(24):E4792-E4801
Mehrotra,S.; Britten,C. D.; Chin,S.; Garrett-Mayer,E.; Cloud,C. A.; Li,M.; Scurti,G.; Salem,M. L.; Nelson,M. H.; Thomas,M. B.; Paulos,C. M.; Salazar,A. M.; Nishimura,M. I.; Rubinstein,M. P.; Li,Z.; Cole,D. J.Vaccination with poly(IC:LC) and peptide-pulsed autologous dendritic cells in patients with pancreatic cancer Journal of hematology & oncology 2017 ;10(1):82-017-0459-2
Sandri,S.; De Sanctis,F.; Lamolinara,A.; Boschi,F.; Poffe,O.; Trovato,R.; Fiore,A.; Sartori,S.; Sbarbati,A.; Bondanza,A.; Cesaro,S.; Krampera,M.; Scupoli,M. T.; Nishimura,M. I.; Iezzi,M.; Sartoris,S.; Bronte,V.; Ugel,S.Effective control of acute myeloid leukaemia and acute lymphoblastic leukaemia progression by telomerase specific adoptive T-cell therapy Oncotarget 2017 ; :
Spear,T. T.; Nishimura,M. I.; Simms,P. E.Comparative exploration of multidimensional flow cytometry software: a model approach evaluating T cell polyfunctional behavior Journal of leukocyte biology 2017 ; :
Spear,T. T.; Wang,Y.; Foley,K. C.; Murray,D. C.; Scurti,G. M.; Simms,P. E.; Garrett-Mayer,E.; Hellman,L. M.; Baker,B. M.; Nishimura,M. I.Critical biological parameters modulate affinity as a determinant of function in T-cell receptor gene-modified T-cells Cancer immunology, immunotherapy : CII 2017 ; :
Breslin,P.; Kuo,P.; Ding,X.; Cotler,S.; Nishimura,M.; Zhang,J.; Qiu,W.; Arteaga,M.; Zaidi,A.; Shang,N.FAK kinase activity is required for the progression of c-Met/beta-catenin-driven HCC Gene expression 2016 ; :
Banerjee,A.; Thyagarajan,K.; Chatterjee,S.; Chakraborty,P.; Kesarwani,P.; Soloshchenko,M.; Hommrani,M. A.; Andrijauskaite,K.; Moxley,K.; Janakiraman,H.; Scheffel,M. J.; Helke,K.; Armeson,K.; Palanisamy,V.; Rubinstein,M. P.; Garrett-Mayer,E.; Cole,D. J.; Paulos,C. M.; Voelkel-Johnson,C.; Nishimura,M. I.; Mehrotra,S.Lack of p53 Augments Anti-Tumor Functions In Cytolytic T Cells Cancer research 2016 ; :
Klarquist,J.; Eby,J. M.; Henning,S. W.; Li,M.; Wainwright,D. A.; Westerhof,W.; Luiten,R. M.; Nishimura,M. I.; Le Poole,I. C.Functional cloning of a gp100-reactive T-cell receptor from vitiligo patient skin Pigment Cell & Melanoma Research 2016 ;29(3):379-384
Sandri,S.; Bobisse,S.; Moxley,K.; Lamolinara,A.; De Sanctis,F.; Boschi,F.; Sbarbati,A.; Fracasso,G.; Ferrarini,G.; Hendriks,R. W.; Cavallini,C.; Scupoli,M. T.; Sartoris,S.; Iezzi,M.; Nishimura,M. I.; Bronte,V.; Ugel,S.Feasibility of Telomerase-Specific Adoptive T-cell Therapy for B-cell Chronic Lymphocytic Leukemia and Solid Malignancies Cancer research 2016 ;76(9):2540-2551
Blevins,S. J.; Pierce,B. G.; Singh,N. K.; Riley,T. P.; Wang,Y.; Spear,T. T.; Nishimura,M. I.; Weng,Z.; Baker,B. M.How structural adaptability exists alongside HLA-A2 bias in the human alphabeta TCR repertoire Proceedings of the National Academy of Sciences of the United States of America 2016 ;113(9):E1276-85
Spear,T. T.; Callender,G. G.; Roszkowski,J. J.; Moxley,K. M.; Simms,P. E.; Foley,K. C.; Murray,D. C.; Scurti,G. M.; Li,M.; Thomas,J. T.; Langerman,A.; Garrett-Mayer,E.; Zhang,Y.; Nishimura,M. I.TCR gene-modified T cells can efficiently treat established hepatitis C-associated hepatocellular carcinoma tumors Cancer immunology, immunotherapy : CII 2016 ;65(3):293-304
Spear,T. T.; Riley,T. P.; Lyons,G. E.; Callender,G. G.; Roszkowski,J. J.; Wang,Y.; Simms,P. E.; Scurti,G. M.; Foley,K. C.; Murray,D. C.; Hellman,L. M.; McMahan,R. H.; Iwashima,M.; Garrett-Mayer,E.; Rosen,H. R.; Baker,B. M.; Nishimura,M. I.Hepatitis C virus-cross-reactive TCR gene-modified T cells: a model for immunotherapy against diseases with genomic instability Journal of leukocyte biology 2016 ; :
Shang,N.; Arteaga,M.; Zaidi,A.; Colter,S.; Breslin,P.; Ding,X.; Kuo,P.; Nishimura,M.; Zhang,J.; Qiu,W.FAK kinase activity is required for the progression of c-Met/beta-catenin-driven HCC Gene expression 2016 ; :
Hellman,L. M.; Yin,L.; Wang,Y.; Blevins,S. J.; Riley,T. P.; Belden,O. S.; Spear,T. T.; Nishimura,M. I.; Stern,L. J.; Baker,B. M.Differential scanning fluorimetry based assessments of the thermal and kinetic stability of peptide-MHC complexes Journal of immunological methods 2016 ;432:95-101
Kesarwani,P.; Chakraborty,P.; Gudi,R.; Chatterjee,S.; Scurti,G.; Toth,K.; Simms,P.; Husain,M.; Armeson,K.; Husain,S.; Garrett-Mayer,E.; Vasu,C.; Nishimura,M. I.; Mehrotra,S.Blocking TCR restimulation induced necroptosis in adoptively transferred T cells improves tumor control Oncotarget 2016 ; :
Na,S.; Arteaga,M.; Zaidi,A.; Colter,S.; Breslin,P.; Ding,X.; Kuo,P.; Nishimura,M.; Zhang,J.; Qiu,W.FAK kinase activity is required for the progression of c-Met/beta-catenin-driven HCC Gene expression 2016 ; :
Scheffel,M. J.; Scurti,G.; Simms,P.; Garrett-Mayer,E.; Mehrotra,S.; Nishimura,M. I.; Voelkel-Johnson,C.Efficacy of Adoptive T-cell Therapy Is Improved by Treatment with the Antioxidant N-Acetyl Cysteine, Which Limits Activation-Induced T-cell Death Cancer research 2016 ;76(20):6006-6016
Spear,T. T.; Nagato,K.; Nishimura,M. I.Strategies to genetically engineer T cells for cancer immunotherapy Cancer immunology, immunotherapy : CII 2016 ;65(6):631-649
Takami,M.; Fujimaki,K.; Nishimura,M. I.; Iwashima,M.Cutting Edge: AhR Is a Molecular Target of Calcitriol in Human T Cells Journal of immunology (Baltimore, Md.: 1950) 2015 ;195(6):2520-2523
You,D.; Xin,J.; Volk,A.; Wei,W.; Schmidt,R.; Scurti,G.; Nand,S.; Breuer,E. K.; Kuo,P. C.; Breslin,P.; Kini,A. R.; Nishimura,M. I.; Zeleznik-Le,N. J.; Zhang,J.FAK Mediates a Compensatory Survival Signal Parallel to PI3K-AKT in PTEN-Null T-ALL Cells Cell reports 2015 ;10(12):2055-2068
Mosenson,J. A.; Zloza,A.; Nieland,J. D.; Garrett-Mayer,E.; Eby,J. M.; Huelsmann,E. J.; Kumar,P.; Denman,C. J.; Lacek,A. T.; Kohlhapp,F. J.; Alamiri,A.; Hughes,T.; Bines,S. D.; Kaufman,H. L.; Overbeck,A.; Mehrotra,S.; Hernandez,C.; Nishimura,M. I.; Guevara-Patino,J. A.; Le Poole,I. C.Mutant HSP70 reverses autoimmune depigmentation in vitiligo Science translational medicine 2013 ;5(174):174ra28
Mehrotra,S.; Al-Khami,A. A.; Klarquist,J.; Husain,S.; Naga,O.; Eby,J. M.; Murali,A. K.; Lyons,G. E.; Li,M.; Spivey,N. D.; Norell,H.; Martins da Palma,T.; Onicescu,G.; Diaz-Montero,C. M.; Garrett-Mayer,E.; Cole,D. J.; Le Poole,I. C.; Nishimura,M. I.A coreceptor-independent transgenic human TCR mediates anti-tumor and anti-self immunity in mice Journal of immunology (Baltimore, Md.: 1950) 2012 ;189(4):1627-1638
Zloza,A.; Jagoda,M. C.; Lyons,G. E.; Graves,M. C.; Kohlhapp,F. J.; O'Sullivan,J. A.; Lacek,A. T.; Nishimura,M. I.; Guevara-Patino,J. A.CD8 co-receptor promotes susceptibility of CD8+ T cells to transforming growth factor-beta (TGF-beta)-mediated suppression Cancer immunology, immunotherapy : CII 2011 ;60(2):291-297
Zhang,Y.; Liu,Y.; Moxley,K. M.; Golden-Mason,L.; Hughes,M. G.; Liu,T.; Heemskerk,M. H.; Rosen,H. R.; Nishimura,M. I.Transduction of human T cells with a novel T-cell receptor confers anti-HCV reactivity PLoS Pathogens 2010 ;6(7):e1001018
Koya,R. C.; Mok,S.; Comin-Anduix,B.; Chodon,T.; Radu,C. G.; Nishimura,M. I.; Witte,O. N.; Ribas,A.Kinetic phases of distribution and tumor targeting by T cell receptor engineered lymphocytes inducing robust antitumor responses Proceedings of the National Academy of Sciences of the United States of America 2010 ;107(32):14286-14291
Klarquist,J.; Denman,C. J.; Hernandez,C.; Wainwright,D. A.; Strickland,F. M.; Overbeck,A.; Mehrotra,S.; Nishimura,M. I.; Le Poole,I. C.Reduced skin homing by functional Treg in vitiligo Pigment Cell & Melanoma Research 2010 ;23(2):276-286
Klarquist,J.; Barfuss,A.; Kandala,S.; Reust,M. J.; Braun,R. K.; Hu,J.; Dilling,D. F.; McKee,M. D.; Boissy,R. E.; Love,R. B.; Nishimura,M. I.; Le Poole,I. C.Melanoma-associated antigen expression in lymphangioleiomyomatosis renders tumor cells susceptible to cytotoxic T cells. American Journal of Pathology 2009 ;175(6):2463-2472
Moore,T. V.; Lyons,G. E.; Brasic,N.; Roszkowski,J. J.; Voelkl,S.; Mackensen,A.; Kast,W. M.; Le Poole,I. C.; Nishimura,M. I.Relationship between CD8-dependent antigen recognition, T cell functional avidity, and tumor cell recognition Cancer immunology, immunotherapy : CII 2009 ;58(5):719-728
McKee,M. D.; Fichera,A.; Nishimura,M. I.T cell immunotherapy Frontiers in bioscience : a journal and virtual library 2007 ;12:919-932
Oyarbide-Valencia,K.; van den Boorn,J. G.; Denman,C. J.; Li,M.; Carlson,J. M.; Hernandez,C.; Nishimura,M. I.; Das,P. K.; Luiten,R. M.; Le Poole,I. C.Therapeutic implications of autoimmune vitiligo T cells Autoimmunity Reviews 2006 ;5(7):486-492
Kaplan,B. L.; Norell,H.; Callender,G. G.; Ohlum,T.; Kiessling,R.; Nishimura,M. I.Interferon-gamma renders tumors that express low levels of Her-2/neu sensitive to cytotoxic T cells Cancer immunology, immunotherapy : CII 2006 ;55(6):653-662
Callender,G. G.; Rosen,H. R.; Roszkowski,J. J.; Lyons,G. E.; Li,M.; Moore,T.; Brasic,N.; McKee,M. D.; Nishimura,M. I.Identification of a hepatitis C virus-reactive T cell receptor that does not require CD8 for target cell recognition Hepatology (Baltimore, Md.) 2006 ;43(5):973-981
Lyons,G. E.; Moore,T.; Brasic,N.; Li,M.; Roszkowski,J. J.; Nishimura,M. I.Influence of human CD8 on antigen recognition by T-cell receptor-transduced cells Cancer research 2006 ;66(23):11455-11461
Lyons,G. E.; Roszkowski,J. J.; Man,S.; Yee,C.; Kast,W. M.; Nishimura,M. I.T-cell receptor tetramer binding or the lack there of does not necessitate antigen reactivity in T-cell receptor transduced T cells Cancer immunology, immunotherapy : CII 2006 ;55(9):1142-1150
Wu,L.; Estrada,O.; Zaborina,O.; Bains,M.; Shen,L.; Kohler,J. E.; Patel,N.; Musch,M. W.; Chang,E. B.; Fu,Y. X.; Jacobs,M. A.; Nishimura,M. I.; Hancock,R. E.; Turner,J. R.; Alverdy,J. C.Recognition of host immune activation by Pseudomonas aeruginosa Science (New York, N.Y.) 2005 ;309(5735):774-777
McKee,M. D.; Roszkowski,J. J.; Nishimura,M. I.T cell avidity and tumor recognition: implications and therapeutic strategies JOURNAL OF TRANSLATIONAL MEDICINE 2005 ;3:35
Roszkowski,J. J.; Lyons,G. E.; Kast,W. M.; Yee,C.; Van Besien,K.; Nishimura,M. I.Simultaneous generation of CD8+ and CD4+ melanoma-reactive T cells by retroviral-mediated transfer of a single T-cell receptor Cancer research 2005 ;65(4):1570-1576
Fujii,S.; Nishimura,M. I.; Lotze,M. T.Regulatory balance between the immune response of tumor antigen-specific T-cell receptor gene-transduced CD8 T cells and the suppressive effects of tolerogenic dendritic cells Cancer science 2005 ;96(12):897-902
Kaplan,B. L.; Moore,T. V.; Schreiber,K.; Callender,G. G.; Schreiber,H.; Nishimura,M. I.A new murine tumor model for studying HLA-A2-restricted anti-tumor immunity Cancer letters 2005 ;224(1):153-166
Nishimura,M. I.; Roszkowski,J. J.; Moore,T. V.; Brasic,N.; McKee,M. D.; Clay,T. M.Antigen recognition and T-cell biology Cancer treatment and research 2005 ;123:37-59
Langerman,A.; Callender,G. G.; Nishimura,M. I.Retroviral transduction of peptide stimulated t cells can generate dual t cell receptor-expressing (bifunctional) t cells reactive with two defined antigens JOURNAL OF TRANSLATIONAL MEDICINE 2004 ;2(1):42
Roszkowski,J. J.; Yu,D. C.; Rubinstein,M. P.; McKee,M. D.; Cole,D. J.; Nishimura,M. I.CD8-independent tumor cell recognition is a property of the T cell receptor and not the T cell Journal of immunology (Baltimore, Md.: 1950) 2003 ;170(5):2582-2589
Lee,K. M.; Bhawan,S.; Majima,T.; Wei,H.; Nishimura,M. I.; Yagita,H.; Kumar,V.Cutting edge: the NK cell receptor 2B4 augments antigen-specific T cell cytotoxicity through CD48 ligation on neighboring T cells Journal of immunology (Baltimore, Md.: 1950) 2003 ;170(10):4881-4885
Kaplan,B. L.; Yu,D. C.; Clay,T. M.; Nishimura,M. I.Redirecting T lymphocyte specificity using T cell receptor genes International reviews of immunology 2003 ;22(3-4):229-253
Eiben,G. L.; da Silva,D. M.; Fausch,S. C.; Le Poole,I. C.; Nishimura,M. I.; Kast,W. M.Cervical cancer vaccines: recent advances in HPV research Viral immunology 2003 ;16(2):111-121
Spiotto,M. T.; Yu,P.; Rowley,D. A.; Nishimura,M. I.; Meredith,S. C.; Gajewski,T. F.; Fu,Y. X.; Schreiber,H.Increasing tumor antigen expression overcomes "ignorance" to solid tumors via crosspresentation by bone marrow-derived stromal cells Immunity 2002 ;17(6):737-747
Dudley,M. E.; Wunderlich,J.; Nishimura,M. I.; Yu,D.; Yang,J. C.; Topalian,S. L.; Schwartzentruber,D. J.; Hwu,P.; Marincola,F. M.; Sherry,R.; Leitman,S. F.; Rosenberg,S. A.Adoptive transfer of cloned melanoma-reactive T lymphocytes for the treatment of patients with metastatic melanoma Journal of immunotherapy (Hagerstown, Md.: 1997) 2001 ;24(4):363-373