Name
Aleksey Zima
Degree
Ph.D.
Rank
Associate Professor
Primary Department
Cell and Molecular Physiology
Appointment Request
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Education
Advanced Degrees
Bogomoletz Institute of Physiology , Kiev , FR , Ukraine
Fellowships
University of Florida, Electrophysiology
Hobbies
History
Sports
Keywords
Arrhythmias
Calcium Signaling
Heart
Ion Channels
Publications
Bovo,E.; Huke,S.; Blatter,L. A.; Zima,A. V.The effect of PKA-mediated phosphorylation of ryanodine receptor on SR Ca2+ leak in ventricular myocytes Journal of Molecular and Cellular Cardiology 2017 ;104:9-16
Bovo,E.; Martin,J. L.; Tyryfter,J.; de Tombe,P. P.; Zima,A. V.R-CEPIA1er as a new tool to directly measure sarcoplasmic reticulum [Ca] in ventricular myocytes American journal of physiology.Heart and circulatory physiology 2016 ;311(1):H268-75
Zima,A. V.; Mazurek,S. R.Functional Impact of Ryanodine Receptor Oxidation on Intracellular Calcium Regulation in the Heart Reviews of physiology, biochemistry and pharmacology 2016 ; :
Bovo,E.; Mazurek,S. R.; Fill,M.; Zima,A. V.Cytosolic Ca(2+) buffering determines the intra-SR Ca(2+) concentration at which cardiac Ca(2+) sparks terminate Cell calcium 2015 ;58(3):246-253
Bovo,E.; Mazurek,S. R.; de Tombe,P. P.; Zima,A. V.Increased Energy Demand during Adrenergic Receptor Stimulation Contributes to Ca(2+) Wave Generation Biophysical journal 2015 ;109(8):1583-1591
Bovo,E.; de Tombe,P. P.; Zima,A. V.The Role of Dyadic Organization in Regulation of Sarcoplasmic Reticulum Ca(2+) Handling during Rest in Rabbit Ventricular Myocytes Biophysical journal 2014 ;106(9):1902-1909
Mazurek,S. R.; Bovo,E.; Zima,A. V.Regulation of sarcoplasmic reticulum Ca(2+) release by cytosolic glutathione in rabbit ventricular myocytes Free radical biology & medicine 2014 ;68:159-167
Zima,A. V.; Bovo,E.; Mazurek,S. R.; Rochira,J. A.; Li,W.; Terentyev,D.Ca handling during excitation-contraction coupling in heart failure Pflugers Archiv : European journal of physiology 2014 ;466(6):1129-1137
Bovo,E.; Dvornikov,A. V.; Mazurek,S. R.; de Tombe,P. P.; Zima,A. V.Mechanisms of Ca(2)+ handling in zebrafish ventricular myocytes Pflugers Archiv : European journal of physiology 2013 ;465(12):1775-1784
Zima,A. V.; Pabbidi,M. R.; Lipsius,S. L.; Blatter,L. A.Effects of mitochondrial uncoupling on Ca(2+) signaling during excitation-contraction coupling in atrial myocytes American journal of physiology.Heart and circulatory physiology 2013 ;304(7):H983-93
Bovo,E.; Lipsius,S. L.; Zima,A. V.Reactive oxygen species contribute to the development of arrhythmogenic Ca2 waves during -adrenergic receptor stimulation in rabbit cardiomyocytes. Journal of Physiology 2012 ;590(Pt 14):3291-3304
Bidwell,P.; Blackwell,D. J.; Hou,Z.; Zima,A. V.; Robia,S. L.Phospholamban binds with differential affinity to calcium pump conformers. Journal of Biological Chemistry 2011 ;286(40):35044-35050
Bovo,E.; Mazurek,S. R.; Blatter,L. A.; Zima,A. V.Regulation of sarcoplasmic reticulum Ca(2)(+) leak by cytosolic Ca(2)(+) in rabbit ventricular myocytes The Journal of physiology 2011 ;589(Pt 24):6039-6050
Picht,E.; Zima,A. V.; Shannon,T. R.; Duncan,A. M.; Blatter,L. A.; Bers,D. M.Dynamic calcium movement inside cardiac sarcoplasmic reticulum during release Circulation research 2011 ;108(7):847-856
Porta,M.; Zima,A. V.; Nani,A.; Diaz-Sylvester,P. L.; Copello,J. A.; Ramos-Franco,J.; Blatter,L. A.; Fill,M.Single ryanodine receptor channel basis of caffeine's action on Ca2+ sparks Biophysical journal 2011 ;100(4):931-938
Sarkey,J. P.; Chu,M.; McShane,M.; Bovo,E.; Mou,Y. A.; Zima,A. V.; de Tombe,P. P.; Kartje,G. L.; Martin,J. L.Nogo-A knockdown inhibits hypoxia/reoxygenation-induced activation of mitochondrial-dependent apoptosis in cardiomyocytes. Journal of Molecular & Cellular Cardiology 2011 ;50(6):1044-1055
Zima,A. V.; Bovo,E.; Bers,D. M.; Blatter,L. A.Ca(2)+ spark-dependent and -independent sarcoplasmic reticulum Ca(2)+ leak in normal and failing rabbit ventricular myocytes The Journal of physiology 2010 ;588(Pt 23):4743-4757
Domeier,T. L.; Blatter,L. A.; Zima,A. V.Changes in intra-luminal calcium during spontaneous calcium waves following sensitization of ryanodine receptor channels Channels (Austin, Tex.) 2010 ;4(2):87-92
Domeier,T. L.; Blatter,L. A.; Zima,A. V.Alteration of sarcoplasmic reticulum Ca2+ release termination by ryanodine receptor sensitization and in heart failure The Journal of physiology 2009 ;587(Pt 21):5197-5209
Qin,J.; Zima,A. V.; Porta,M.; Blatter,L. A.; Fill,M.Trifluoperazine: a rynodine receptor agonist Pflugers Archiv : European journal of physiology 2009 ;458(4):643-651
Zima,A. V.; Picht,E.; Bers,D. M.; Blatter,L. A.Partial inhibition of sarcoplasmic reticulum ca release evokes long-lasting ca release events in ventricular myocytes: role of luminal ca in termination of ca release. Biophysical journal 2008 ;94(5):1867-1879
Zima,A. V.; Picht,E.; Bers,D. M.; Blatter,L. A.Termination of cardiac Ca2+ sparks: role of intra-SR [Ca2+], release flux, and intra-SR Ca2+ diffusion Circulation research 2008 ;103(8):e105-15
Domeier,T. L.; Zima,A. V.; Maxwell,J. T.; Huke,S.; Mignery,G. A.; Blatter,L. A.IP3 receptor-dependent Ca2+ release modulates excitation-contraction coupling in rabbit ventricular myocytes American Journal of Physiology - Heart & Circulatory Physiology 2008 ;294(2):H596-604
Wang,Y. G.; Zima,A. V.; Ji,X.; Pabbidi,R.; Blatter,L. A.; Lipsius,S. L.Ginsenoside Re suppresses electromechanical alternans in cat and human cardiomyocytes. American Journal of Physiology - Heart & Circulatory Physiology 2008 ;295(2):H851-9
Zima,A. V.; Qin,J.; Fill,M.; Blatter,L. A.Tricyclic antidepressant amitriptyline alters sarcoplasmic reticulum calcium handling in ventricular myocytes American journal of physiology.Heart and circulatory physiology 2008 ;295(5):H2008-16
Kockskamper,J.; Zima,A. V.; Roderick,H. L.; Pieske,B.; Blatter,L. A.; Bootman,M. D.Emerging roles of inositol 1,4,5-trisphosphate signaling in cardiac myocytes Journal of Molecular and Cellular Cardiology 2008 ;45(2):128-147
Jung,C.; Zima,A. V.; Szentesi,P.; Jona,I.; Blatter,L. A.; Niggli,E.Ca2+ release from the sarcoplasmic reticulum activated by the low affinity Ca2+ chelator TPEN in ventricular myocytes Cell calcium 2007 ;41(2):187-194
Zima,A. V.; Bare,D. J.; Mignery,G. A.; Blatter,L. A.IP3-dependent nuclear Ca2+ signalling in the mammalian heart. Journal of Physiology 2007 ;584(Pt 2):601-611
Picht,E.; Zima,A. V.; Blatter,L. A.; Bers,D. M.SparkMaster: automated calcium spark analysis with ImageJ. American Journal of Physiology - Cell Physiology 2007 ;293(3):1073-1081
Aromolaran,A. S.; Zima,A. V.; Blatter,L. A.Role of glycolytically generated ATP for CaMKII-mediated regulation of intracellular Ca2+ signaling in bovine vascular endothelial cells. American Journal of Physiology - Cell Physiology 2007 ;293(1):106-118
Copello,J. A.; Zima,A. V.; Diaz-Sylvester,P. L.; Fill,M.; Blatter,L. A.Ca2+ entry-independent effects of L-type Ca2+ channel modulators on Ca2+ sparks in ventricular myocytes American journal of physiology.Cell physiology 2007 ;292(6):C2129-40
Zima,A. V.; Blatter,L. A.Redox regulation of cardiac calcium channels and transporters Cardiovascular research 2006 ;71(2):310-321
Zima,A. V.; Kockskamper,J.; Blatter,L. A.Cytosolic energy reserves determine the effect of glycolytic sugar phosphates on sarcoplasmic reticulum Ca2+ release in cat ventricular myocytes The Journal of physiology 2006 ;577(Pt 1):281-293
Remus,T. P.; Zima,A. V.; Bossuyt,J.; Bare,D. J.; Martin,J. L.; Blatter,L. A.; Bers,D. M.; Mignery,G. A.Biosensors to measure inositol 1,4,5-trisphosphate concentration in living cells with spatiotemporal resolution. Journal of Biological Chemistry 2006 ;281(1):608-616
Sheehan,K. A.; Zima,A. V.; Blatter,L. A.Regional differences in spontaneous Ca2+ spark activity and regulation in cat atrial myocytes. Journal of Physiology 2006 ;572(Pt 3):799-809
Li,X.; Zima,A. V.; Sheikh,F.; Blatter,L. A.; Chen,J.Endothelin-1-induced arrhythmogenic Ca2+ signaling is abolished in atrial myocytes of inositol-1,4,5-trisphosphate(IP3)-receptor type 2-deficient mice Circulation research 2005 ;96(12):1274-1281
Kockskamper,J.; Zima,A. V.; Blatter,L. A.Modulation of sarcoplasmic reticulum Ca2+ release by glycolysis in cat atrial myocytes The Journal of physiology 2005 ;564(Pt 3):697-714
Cherednichenko,G.; Zima,A. V.; Feng,W.; Schaefer,S.; Blatter,L. A.; Pessah,I. N.NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates calcium-induced calcium release Circulation research 2004 ;94(4):478-486
Zima,A. V.; Blatter,L. A.Inositol-1,4,5-trisphosphate-dependent Ca(2+) signalling in cat atrial excitation-contraction coupling and arrhythmias. Journal of Physiology 2004 ;555(Pt 3):607-615
Zima,A. V.; Copello,J. A.; Blatter,L. A.Effects of cytosolic NADH/NAD(+) levels on sarcoplasmic reticulum Ca(2+) release in permeabilized rat ventricular myocytes. Journal of Physiology 2004 ;555(Pt 3):727-741
Kockskamper,J.; Ahmmed,G. U.; Zima,A. V.; Sheehan,K. A.; Glitsch,H. G.; Blatter,L. A.Palytoxin disrupts cardiac excitation-contraction coupling through interactions with P-type ion pumps. American Journal of Physiology - Cell Physiology 2004 ;287(2):527-538
Zima,A. V.; Copello,J. A.; Blatter,L. A.Differential modulation of cardiac and skeletal muscle ryanodine receptors by NADH. FEBS letters 2003 ;547(1-3):32-36
Zima,A. V.; Kockskamper,J.; Mejia-Alvarez,R.; Blatter,L. A.Pyruvate modulates cardiac sarcoplasmic reticulum Ca2+ release in rats via mitochondria-dependent and -independent mechanisms. Journal of Physiology 2003 ;550(Pt 3):765-783
Blatter,L. A.; Kockskamper,J.; Sheehan,K. A.; Zima,A. V.; Huser,J.; Lipsius,S. L.Local calcium gradients during excitation-contraction coupling and alternans in atrial myocytes The Journal of physiology 2003 ;546(Pt 1):19-31