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Paul C. Kuo
Primary Department
Surgical Oncology
Joint Department
Public Health Sciences
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Liver Transplant
Bile Duct Cancer
Gallbladder Disorders
Minimally Invasive Surgery
Liver Cancer
Liver Disorders
Bile Duct Disorders
Gastroesophageal Reflux (GERD)
Gastrointestinal Surgery
Loyola Hospital
American Board of Surgery Subspecialty Surgical Critical Care
Medical School
Johns Hopkins University School of Medicine
Brigham and Women's Hospital, General Surgery
Beth Israel Deaconess Medical Center/Harvard University Medical School, Transplant/Hepatobiliary Surgery
Erickson,T.; Vana,P. G.; Blanco,B. A.; Brownlee,S. A.; Paddock,H. N.; Kuo,P. C.; Kothari,A. N.Impact of hospital transfer on surgical outcomes of intestinal atresia American Journal of Surgery 2017 ;213(3):516-520
Kothari,A. N.; Brownlee,S. A.; Blackwell,R. H.; Zapf,M. A.; Markossian,T.; Gupta,G. N.; Kuo,P. C.Association Between Elements of Electronic Health Record Systems and the Weekend Effect in Urgent General Surgery JAMA surgery 2017 ; :
Cobb,A. N.; Wong,Y. M.; Brownlee,S. A.; Blanco,B. A.; Ezure,Y.; Paddock,H. N.; Kuo,P. C.; Kothari,A. N.Perioperative support, not volume, is necessary to optimize outcomes in surgical management of necrotizing enterocolitis American Journal of Surgery 2017 ;213(3):502-506
Chang,V.; Blackwell,R. H.; Markossian,T.; Yau,R. M.; Blanco,B. A.; Zapf,M. A. C.; Abood,G. J.; Gupta,G. N.; Kuo,P. C.; Kothari,A. N.Discordance between surgical care improvement project adherence and postoperative outcomes: implications for new Joint Commission standards The Journal of surgical research 2017 ;212:205-213
Shah,A. S.; Blackwell,R. H.; Kuo,P. C.; Gupta,G. N.Rates and Risk Factors for Opioid Dependence and Overdose After Urologic Surgery The Journal of urology 2017 ; :
Blackwell,R. H.; Vedachalam,S.; Shah,A. S.; Kothari,A. N.; Kuo,P. C.; Gupta,G. N.; Turk,T. M. T.Postoperative Urinary Retention is an Independent Predictor of Short- and Long-Term Future Bladder Outlet Procedure in Men The Journal of urology 2017 ; :
Blanco,B. A.; Kothari,A. N.; Blackwell,R. H.; Brownlee,S. A.; Yau,R. M.; Attisha,J. P.; Ezure,Y.; Pappas,S.; Kuo,P. C.; Abood,G. J."Take the Volume Pledge" may result in disparity in access to care Surgery 2017 ;161(3):837-845
Blanco,B. A.; Kothari,A. N.; Halandras,P. M.; Blackwell,R. H.; Graunke,D. M.; Kuo,P. C.; Cho,J. S.Transient atrial fibrillation after open abdominal aortic revascularization surgery is associated with increased length of stay, mortality, and readmission rates Journal of Vascular Surgery 2017 ; :
Kothari,A. N.; Loy,V. M.; Brownlee,S. A.; Ezure,Y.; Schaidle-Blackburn,C.; Cotler,S. J.; di Sabato,D.; Kuo,P. C.; Lu,A. D.Adverse Effect of Post-Discharge Care Fragmentation on Outcomes after Readmissions after Liver Transplantation Journal of the American College of Surgeons 2017 ; :
Chang,V.; Blackwell,R. H.; Yau,R. M.; Besser,S.; Albright,J. M.; Gupta,G. N.; Kuo,P. C.; Kothari,A. N.Variable surgical outcomes after hospital consolidation: Implications for local health care delivery Surgery 2016 ;160(5):1155-1161
Thalji,S. Z.; Kothari,A. N.; Kuo,P. C.; Mosier,M. J.Acute Kidney Injury in Burn Patients: Clinically Significant Over the Initial Hospitalization and 1 Year After Injury: An Original Retrospective Cohort Study Annals of Surgery 2016 ; :
Nassoiy,S. P.; Blackwell,R. H.; Kothari,A. N.; Besser,S.; Gupta,G. N.; Kuo,P. C.; Abood,G. J.New onset postoperative atrial fibrillation predicts long-term cardiovascular events after gastrectomy American Journal of Surgery 2016 ;211(3):559-564
Arffa,M. L.; Zapf,M. A.; Kothari,A. N.; Chang,V.; Gupta,G. N.; Ding,X.; Al-Gayyar,M. M.; Syn,W.; Elsherbiny,N. M.; Kuo,P. C.; Mi,Z.Epigallocatechin-3-Gallate Upregulates miR-221 to Inhibit Osteopontin-Dependent Hepatic Fibrosis PLoS ONE 2016 ;11(12):e0167435
Greco,K. A.; Franzen,C. A.; Foreman,K. E.; Flanigan,R. C.; Kuo,P. C.; Gupta,G. N.PLK-1 Silencing in Bladder Cancer by siRNA Delivered With Exosomes Urology 2016 ;91:241.e1-241.e7
Weber,C. E.; Ersahin,C. H.; Kuo,P. C.; Mi,Z.Pancreatic Cancer and Osteopontin: The Relationship Remains Unclear Pancreas 2016 ;45(7):e35-6
Brownlee,S. A.; Blackwell,R. H.; Blanco,B. A.; Zapf,M. A.; Kliethermes,S.; Gupta,G. N.; Kuo,P. C.; Kothari,A. N.Impact of Post-Hospital Syndrome on Outcomes Following Elective, Ambulatory Surgery Annals of Surgery 2016 ; :
Shang,N.; Arteaga,M.; Zaidi,A.; Colter,S.; Breslin,P.; Ding,X.; Kuo,P.; Nishimura,M.; Zhang,J.; Qiu,W.FAK kinase activity is required for the progression of c-Met/beta-catenin-driven HCC Gene expression 2016 ; :
Baldea,K. G.; Blackwell,R. H.; Vedachalam,S.; Kothari,A. N.; Kuo,P. C.; Gupta,G. N.; Turk,T. M.Outcomes of percutaneous nephrolithotomy in spinal cord injury patients as compared to a matched cohort Urolithiasis 2016 ; :
Breslin,P.; Kuo,P.; Ding,X.; Cotler,S.; Nishimura,M.; Zhang,J.; Qiu,W.; Arteaga,M.; Zaidi,A.; Shang,N.FAK kinase activity is required for the progression of c-Met/beta-catenin-driven HCC Gene expression 2016 ; :
Kothari,A. N.; Blanco,B. A.; Brownlee,S. A.; Evans,A. E.; Chang,V. A.; Abood,G. J.; Settimi,R.; Raicu,D. S.; Kuo,P. C.Characterizing the role of a high-volume cancer resection ecosystem on low-volume, high-quality surgical care Surgery 2016 ;160(4):839-849
Kothari,A. N.; Halandras,P. M.; Drescher,M.; Blackwell,R. H.; Graunke,D. M.; Kliethermes,S.; Kuo,P. C.; Cho,J. S.Transient postoperative atrial fibrillation after abdominal aortic aneurysm repair increases mortality risk Journal of Vascular Surgery 2016 ;63(5):1240-1247
Kothari,A. N.; Yau,R. M.; Blackwell,R. H.; Schaidle-Blackburn,C.; Markossian,T.; Zapf,M. A.; Lu,A. D.; Kuo,P. C.Inpatient Rehabilitation after Liver Transplantation Decreases Risk and Severity of 30-Day Readmissions Journal of the American College of Surgeons 2016 ; :
Coombes,J. D.; Choi,S. S.; Swiderska-Syn,M.; Manka,P.; Reid,D. T.; Palma,E.; Briones-Orta,M. A.; Xie,G.; Younis,R.; Kitamura,N.; Della Peruta,M.; Bitencourt,S.; Dolle,L.; Oo,Y. H.; Mi,Z.; Kuo,P. C.; Williams,R.; Chokshi,S.; Canbay,A.; Claridge,L. C.; Eksteen,B.; Diehl,A. M.; Syn,W. K.Osteopontin is a proximal effector of leptin-mediated non-alcoholic steatohepatitis (NASH) fibrosis Biochimica et biophysica acta 2016 ;1862(1):135-144
Xin,J.; You,D.; Breslin,P.; Li,J.; Zhang,J.; Wei,W.; Cannova,J.; Volk,A.; Gutierrez,R.; Xiao,Y.; Ni,A.; Ng,G.; Schmidt,R.; Xia,Z.; Pan,J.; Chen,H.; Patel,M. M.; Kuo,P. C.; Nand,S.; Kini,A. R.; Zhang,J.; Chen,J.; Zhu,J.; Zhang,J.Sensitizing acute myeloid leukemia cells to induced differentiation by inhibiting the RIP1/RIP3 pathway Leukemia 2016 ; :
Xin,J.; Breslin,P.; Wei,W.; Li,J.; Gutierrez,R.; Cannova,J.; Ni,A.; Ng,G.; Schmidt,R.; Chen,H.; Parini,V.; Kuo,P. C.; Kini,A. R.; Stiff,P.; Zhu,J.; Zhang,J.Necroptosis in spontaneously-mutated hematopoietic cells induces autoimmune bone marrow failure in mice Haematologica 2016 ; :
Blackwell,R. H.; Barton,G. J.; Kothari,A. N.; Zapf,M. A.; Flanigan,R. C.; Kuo,P. C.; Gupta,G. N.Early Intervention during Acute Stone Admissions: Revealing "The Weekend Effect" in Urological Practice The Journal of urology 2016 ; :
Na,S.; Arteaga,M.; Zaidi,A.; Colter,S.; Breslin,P.; Ding,X.; Kuo,P.; Nishimura,M.; Zhang,J.; Qiu,W.FAK kinase activity is required for the progression of c-Met/beta-catenin-driven HCC Gene expression 2016 ; :
Kothari,A. N.; Arffa,M. L.; Chang,V.; Blackwell,R. H.; Syn,W. K.; Zhang,J.; Mi,Z.; Kuo,P. C.Osteopontin-A Master Regulator of Epithelial-Mesenchymal Transition Journal of clinical medicine 2016 ;5(4):10.3390/jcm5040039
You,D.; Xin,J.; Volk,A.; Wei,W.; Schmidt,R.; Scurti,G.; Nand,S.; Breuer,E. K.; Kuo,P. C.; Breslin,P.; Kini,A. R.; Nishimura,M. I.; Zeleznik-Le,N. J.; Zhang,J.FAK Mediates a Compensatory Survival Signal Parallel to PI3K-AKT in PTEN-Null T-ALL Cells Cell reports 2015 ;10(12):2055-2068
Kothari,A. N.; Zapf,M. A.; Blackwell,R. H.; Markossian,T.; Chang,V.; Mi,Z.; Gupta,G. N.; Kuo,P. C.Components of Hospital Perioperative Infrastructure Can Overcome the Weekend Effect in Urgent General Surgery Procedures Annals of Surgery 2015 ;262(4):683-691
Blackwell,R. H.; Ellimoottil,C.; Bajic,P.; Kothari,A.; Zapf,M.; Kliethermes,S.; Flanigan,R. C.; Quek,M. L.; Kuo,P. C.; Gupta,G. N.New Onset Postoperative Atrial Fibrillation Predicts Long-Term Cardiovascular Events Following Radical Cystectomy The Journal of urology 2015 ;194(4):944-949
Cobb,A.; Ngo,J.; Kuo,P. C.Intra-operative acoustic enhancement The American Surgeon 2015 ;81(6):248-249
Coombes,J. D.; Swiderska-Syn,M.; Dolle,L.; Reid,D.; Eksteen,B.; Claridge,L.; Briones-Orta,M. A.; Shetty,S.; Oo,Y. H.; Riva,A.; Chokshi,S.; Papa,S.; Mi,Z.; Kuo,P. C.; Williams,R.; Canbay,A.; Adams,D. H.; Diehl,A. M.; van Grunsven,L. A.; Choi,S. S.; Syn,W. K.Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice Gut 2015 ;64(7):1120-1131
Franzen,C. A.; Blackwell,R. H.; Foreman,K. E.; Kuo,P. C.; Flanigan,R. C.; Gupta,G. N.Urinary Exosomes: The Potential for Biomarker Utility, Intercellular Signaling and Therapeutics in Urological Malignancy The Journal of urology 2015 ; :
Zapf,M. A.; Kothari,A. N.; Markossian,T.; Gupta,G. N.; Blackwell,R. H.; Wai,P. Y.; Weber,C. E.; Driver,J.; Kuo,P. C.The "weekend effect" in urgent general operative procedures Surgery 2015 ;158(2):508-514
Kothari,A. N.; Liles,J. L.; Holmes,C. J.; Zapf,M. A.; Blackwell,R. H.; Kliethermes,S.; Kuo,P. C.; Luchette,F. A."Right place at the right time" impacts outcomes for acute intestinal obstruction Surgery 2015 ;158(4):1116-25; discussion 1125-7
Li,N. Y.; Tong,L.; Barbas,A. S.; Bhattacharya,S. D.; Wai,P. Y.; Kuo,P. C.Renal response following perioperative ketorolac analgesia in living kidney donation Transplantation 2015 ;99(3):e22-3
Zapf,M. A.; Kothari,A. N.; Weber,C. E.; Arffa,M. L.; Wai,P. Y.; Driver,J.; Gupta,G. N.; Kuo,P. C.; Mi,Z.Green tea component epigallocatechin-3-gallate decreases expression of osteopontin via a decrease in mRNA half-life in cell lines of metastatic hepatocellular carcinoma Surgery 2015 ;158(4):1039-1048
Franzen,C. A.; Blackwell,R. H.; Todorovic,V.; Greco,K. A.; Foreman,K. E.; Flanigan,R. C.; Kuo,P. C.; Gupta,G. N.Urothelial cells undergo epithelial-to-mesenchymal transition after exposure to muscle invasive bladder cancer exosomes Oncogenesis 2015 ;4:e163
Driver,J.; Weber,C. E.; Callaci,J. J.; Kothari,A. N.; Zapf,M. A.; Roper,P. M.; Borys,D.; Franzen,C. A.; Gupta,G. N.; Wai,P. Y.; Zhang,J.; Denning,M. F.; Kuo,P. C.; Mi,Z.Alcohol inhibits osteopontin-dependent transforming growth factor-beta1 expression in human mesenchymal stem cells The Journal of biological chemistry 2015 ;290(16):9959-9973
Weber,C. E.; Kothari,A. N.; Wai,P. Y.; Li,N. Y.; Driver,J.; Zapf,M. A.; Franzen,C. A.; Gupta,G. N.; Osipo,C.; Zlobin,A.; Syn,W. K.; Zhang,J.; Kuo,P. C.; Mi,Z.Osteopontin mediates an MZF1-TGF-beta1-dependent transformation of mesenchymal stem cells into cancer-associated fibroblasts in breast cancer Oncogene 2014 ;34(37):4821-4833
Foreman,K. E.; Jesse,J. N.,3rd; Kuo,P. C.; Gupta,G. N.Emetine dihydrochloride: a novel therapy for bladder cancer The Journal of urology 2014 ;191(2):502-509
Franzen,C. A.; Simms,P. E.; Van Huis,A. F.; Foreman,K. E.; Kuo,P. C.; Gupta,G. N.Characterization of uptake and internalization of exosomes by bladder cancer cells BioMed research international 2014 ;2014:619829
Kothari,A. N.; Mi,Z.; Zapf,M.; Kuo,P. C.Novel clinical therapeutics targeting the epithelial to mesenchymal transition Clinical and translational medicine 2014 ;3:35-014-0035-0. eCollection 2014
Guo,H.; Gao,C.; Mi,Z.; Wai,P. Y.; Kuo,P. C.Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4a transcriptional activity The Biochemical journal 2014 ;461(2):347
Volk,A.; Li,J.; Xin,J.; You,D.; Zhang,J.; Liu,X.; Xiao,Y.; Breslin,P.; Li,Z.; Wei,W.; Schmidt,R.; Li,X.; Zhang,Z.; Kuo,P. C.; Nand,S.; Zhang,J.; Chen,J.; Zhang,J.Co-inhibition of NF-kappaB and JNK is synergistic in TNF-expressing human AML The Journal of experimental medicine 2014 ;211(6):1093-1108
Wai,P. Y.; Dandar,V.; Radosevich,D. M.; Brubaker,L.; Kuo,P. C.Engagement, workplace satisfaction, and retention of surgical specialists in academic medicine in the United States Journal of the American College of Surgeons 2014 ;219(1):31-42.e12
Choi,S. S.; Claridge,L. C.; Jhaveri,R.; Swiderska-Syn,M.; Clark,P.; Suzuki,A.; Pereira,T. A.; Mi,Z.; Kuo,P. C.; Guy,C. D.; Pereira,F. E.; Diehl,A. M.; Patel,K.; Syn,W. K.Osteopontin is up-regulated in chronic hepatitis C and is associated with cellular permissiveness for hepatitis C virus replication Clinical science (London, England : 1979) 2014 ;126(12):845-855
Chang,V.; Kuo,P. C.; Wai,P. Y.Doing well by doing good: linking access with quality American Journal of Surgery 2014 ;209(3):457-462
Hsueh,Y. J.; Kuo,P. C.; Chen,J. K.Transcriptional regulators of the DeltaNp63: their role in limbal epithelial cell proliferation Journal of cellular physiology 2013 ;228(3):536-546
Ellimoottil,C.; Brandt,W.; Bernardi,K.; Evans,A.; Mehta,V.; Picken,M. M.; Phelan,K.; Heinrich,L.; Milner,J.; Wai,P. Y.; Asolati,M.; Kuo,P. C.; Lu,A. D.Acute graft dysfunction after living-related renal transplant Urology 2013 ;82(4):764-767
Li,N. Y.; Weber,C. E.; Mi,Z.; Wai,P. Y.; Cuevas,B. D.; Kuo,P. C.Osteopontin up-regulates critical epithelial-mesenchymal transition transcription factors to induce an aggressive breast cancer phenotype Journal of the American College of Surgeons 2013 ;217(1):17-26; discussion 26
Li,N. Y.; Weber,C. E.; Wai,P. Y.; Cuevas,B. D.; Zhang,J.; Kuo,P. C.; Mi,Z.An MAPK-dependent pathway induces epithelial-mesenchymal transition via Twist activation in human breast cancer cell lines Surgery 2013 ;154(2):404-410
Jing,Y. H.; Chen,K. H.; Kuo,P. C.; Pao,C. C.; Chen,J. K.Neurodegeneration in streptozotocin-induced diabetic rats is attenuated by treatment with resveratrol Neuroendocrinology 2013 ;98(2):116-127
Weber,C. E.; Talbot,L. J.; Geller,J. M.; Kuo,M. C.; Wai,P. Y.; Kuo,P. C.Comparing 20 years of national general surgery malpractice claims data: obesity versus morbid obesity American Journal of Surgery 2013 ;205(3):293-7; discussion 297
Weber,C. E.; Talbot,L. J.; Geller,J. M.; Kuo,M. C.; Wai,P. Y.; Kuo,P. C.Obesity and trends in malpractice claims for physicians and surgeons Surgery 2013 ;154(2):299-304
Bhattacharya,S. D.; Mi,Z.; Kim,V. M.; Guo,H.; Talbot,L. J.; Kuo,P. C.Osteopontin regulates epithelial mesenchymal transition-associated growth of hepatocellular cancer in a mouse xenograft model Annals of Surgery 2012 ;255(2):319-325
Bhattacharya,S. D.; Mi,Z.; Talbot,L. J.; Guo,H.; Kuo,P. C.Human mesenchymal stem cell and epithelial hepatic carcinoma cell lines in admixture: concurrent stimulation of cancer-associated fibroblasts and epithelial-to-mesenchymal transition markers Surgery 2012 ;152(3):449-454
Wai,P. Y.; Kuo,P. C.Intersecting pathways in inflammation and cancer: Hepatocellular carcinoma as a paradigm World journal of clinical oncology 2012 ;3(2):15-23
Wai,P. Y.; O'Hern,T.; Andersen,D. O.; Kuo,M. C.; Weber,C. E.; Talbot,L. J.; Kuo,P. C.Impact of business infrastructure on financial metrics in departments of surgery. Surgery 2012 ;152(4):729-734
Weber,C. E.; Kuo,P. C.The tumor microenvironment Surgical oncology 2012 ;21(3):172-177
Weber,C. E.; Li,N. Y.; Wai,P. Y.; Kuo,P. C.Epithelial-mesenchymal transition, TGF-beta, and osteopontin in wound healing and tissue remodeling after injury Journal of Burn Care & Research 2012 ;33(3):311-318
Mehta,A.; Baker,T. A.; Shoup,M.; Brownson,K.; Amde,S.; Doren,E.; Shah,S.; Kuo,P.; Angelats,J.Biplanar flap reconstruction for pressure ulcers: experience in patients with immobility from chronic spinal cord injuries American Journal of Surgery 2012 ;203(3):303-6; discussion 306-7
Hunter,C.; Bond,J.; Kuo,P. C.; Selim,M. A.; Levinson,H.The role of osteopontin and osteopontin aptamer (OPN-R3) in fibroblast activity The Journal of surgical research 2012 ;176(1):348-358
Fisichella,P. M.; Pittman,M.; Kuo,P. C.Laparoscopic Treatment of Epiphrenic Diverticula: Preoperative Evaluation and Surgical Technique. How I Do It Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2011 ;15(10):1861-71
Fisichella,P. M.; Davis,C. S.; Lundberg,P. W.; Lowery,E.; Burnham,E. L.; Alex,C. G.; Ramirez,L.; Pelletiere,K.; Love,R. B.; Kuo,P. C.; Kovacs,E. J.The protective role of laparoscopic antireflux surgery against aspiration of pepsin after lung transplantation. Surgery 2011 ;150(4):598-606
Zhang,J.; Guo,H.; Mi,Z.; Gao,C.; Bhattacharya,S.; Li,J.; Kuo,P. C.EF1A1-actin interactions alter mRNA stability to determine differential osteopontin expression in HepG2 and Hep3B cells. Experimental cell research 2009 ;315(2):304-312
Scarborough,J. E.; Bennett,K. M.; Schroeder,R. A.; Swedish,T. B.; Jacobs,D. O.; Kuo,P. C.Will the clinicians support the researchers and teachers? Results of a salary satisfaction survey of 947 academic surgeons. Annals of Surgery 2009 ;250(3):432-439
Mi,Z.; Guo,H.; Kuo,P. C.Identification of osteopontin-dependent signaling pathways in a mouse model of human breast cancer BMC research notes 2009 ;2:119-0500-2-119
Mi,Z.; Guo,H.; Russell,M. B.; Liu,Y.; Sullenger,B. A.; Kuo,P. C.RNA aptamer blockade of osteopontin inhibits growth and metastasis of MDA-MB231 breast cancer cells. Molecular Therapy: the Journal of the American Society of Gene Therapy 2009 ;17(1):153-161
Aggarwal,H.; Smith,A. D.; Kuo,P. C.; Vikraman,D. S.Streptococcus equi primary bacteremia in a hepatitis-C cirrhotic patient. Transplantation 2009 ;87(5):783
Schroeder,R. A.; Kuo,P. C.Pro: low central venous pressure during liver transplantation--not too low Journal of Cardiothoracic & Vascular Anesthesia 2008 ;22(2):311-314
Emani,S.; Zhang,J.; Guo,L.; Guo,H.; Kuo,P. C.RNA stability regulates differential expression of the metastasis protein, osteopontin, in hepatocellular cancer. Surgery 2008 ;143(6):803-812
Alexander,J. W.; Goodman,H. R.; Succop,P.; Light,J. A.; Kuo,P. C.; Moser,A. B.; James,J. H.; Woodle,E. S.Influence of long chain polyunsaturated fatty acids and ornithine concentrations on complications after renal transplant. Experimental & Clinical Transplantation: Official Journal of the Middle East Society for Organ Transplantation 2008 ;6(2):118-126
Takami,Y.; Higashi,M.; Kumagai,S.; Kuo,P. C.; Kawana,H.; Koda,K.; Miyazaki,M.; Harigaya,K.The activity of RhoA is correlated with lymph node metastasis in human colorectal cancer. Digestive Diseases & Sciences 2008 ;53(2):467-473
Guo,H.; Mi,Z.; Kuo,P. C.Characterization of short range DNA looping in endotoxin-mediated transcription of the murine inducible nitric-oxide synthase (iNOS) gene. Journal of Biological Chemistry 2008 ;283(37):25209-25217
Guo,H.; Wai,P. Y.; Mi,Z.; Gao,C.; Zhang,J.; Kuo,P. C.Osteopontin mediates Stat1 degradation to inhibit iNOS transcription in a cecal ligation and puncture model of sepsis. Surgery 2008 ;144(2):182-188
Scarborough,J. E.; Pietrobon,R.; Tuttle-Newhall,J. E.; Marroquin,C. E.; Collins,B. H.; Desai,D. M.; Kuo,P. C.; Pappas,T. N.Relationship between provider volume and outcomes for orthotopic liver transplantation. Journal of Gastrointestinal Surgery 2008 ;12(9):1527-1533
Scarborough,J. E.; Tuttle-Newhall,J. E.; Pietrobon,R.; Marroquin,C. E.; Collins,B. H.; Desai,D. M.; Kuo,P. C.; Pappas,T. N.Supply and demand for liver transplant surgery: are we training enough surgeons?. HPB 2008 ;10(1):25-29
Kuo,P. C.; Schroeder,R. A.; Shah,A.; Shah,J.; Jacobs,D. O.; Pietrobon,R."Ghost" publications among applicants to a general surgery residency program. Journal of the American College of Surgeons 2008 ;207(4):485-489
Wai,P. Y.; Kuo,P. C.Osteopontin: regulation in tumor metastasis Cancer & Metastasis Reviews 2008 ;27(1):103-118
Wai,P. Y.; Reddy,S. K.; Kuo,P. C.Functional analysis of tumor metastasis: modeling colon cancer Oncology Reviews 2008 ;2(1):9-20
Scarborough,J. E.; Pietrobon,R.; Bennett,K. M.; Clary,B. M.; Kuo,P. C.; Tyler,D. S.; Pappas,T. N.Workforce projections for hepato-pancreato-biliary surgery. Journal of the American College of Surgeons 2008 ;206(4):678-684
Scarborough,J. E.; Pietrobon,R.; Clary,B. M.; Marroquin,C. E.; Bennett,K. M.; Kuo,P. C.; Pappas,T. N.Regionalization of hepatic resections is associated with increasing disparities among some patient populations in use of high-volume providers. Journal of the American College of Surgeons 2008 ;207(6):831-838
Scarborough,J. E.; Pietrobon,R.; Marroquin,C. E.; Tuttle-Newhall,J. E.; Kuo,P. C.; Collins,B. H.; Desai,D. M.; Pappas,T. N.Temporal trends in early clinical outcomes and health care resource utilization for liver transplantation in the United States. Journal of Gastrointestinal Surgery 2007 ;11(1):82-88
Mi,Z.; Oliver,T.; Guo,H.; Gao,C.; Kuo,P. C.Thrombin-cleaved COOH(-) terminal osteopontin peptide binds with cyclophilin C to CD147 in murine breast cancer cells. Cancer research 2007 ;67(9):4088-4097
Guo,L.; Guo,H.; Gao,C.; Mi,Z.; Russell,W. B.; Kuo,P. C.Stat1 acetylation inhibits inducible nitric oxide synthase expression in interferon-gamma-treated RAW264.7 murine macrophages. Surgery 2007 ;142(2):156-162
Cibrik,D.; Meier-Kriesche,H. U.; Bresnahan,B.; Wu,Y. M.; Klintmalm,G.; Kew,C. E.; Kuo,P. C.; Whelchel,J.; Cohen,D.; Baliga,P.; Akalin,E.; Benedetti,E.; Wright,F.; Lieberman,B.; Ulbricht,B.; Jensik,S.; Myfortic-US01 Renal Transplant Study,GroupRenal function with cyclosporine C2 monitoring, enteric-coated mycophenolate sodium and basiliximab: a 12-month randomized trial in renal transplant recipients. Clinical transplantation 2007 ;21(2):192-201
Reddy,S. K.; Barbas,A. S.; Marroquin,C. E.; Morse,M. A.; Kuo,P. C.; Clary,B. M.Resection of noncolorectal nonneuroendocrine liver metastases: a comparative analysis. Journal of the American College of Surgeons 2007 ;204(3):372-382
Gao,C.; Guo,H.; Mi,Z.; Grusby,M. J.; Kuo,P. C.Osteopontin induces ubiquitin-dependent degradation of STAT1 in RAW264.7 murine macrophages. Journal of Immunology 2007 ;178(3):1870-1881
Gao,C.; Mi,Z.; Guo,H.; Kuo,P. C.Osteopontin regulates ubiquitin-dependent degradation of Stat1 in murine mammary epithelial tumor cells. Neoplasia (New York) 2007 ;9(9):699-706
Guo,H.; Gao,C.; Mi,Z.; Zhang,J.; Kuo,P. C.Characterization of the PC4 binding domain and its interactions with HNF4alpha. Journal of Biochemistry 2007 ;141(5):635-640
Shah,A.; Pietrobon,R.; Cook,C.; Sheth,N. P.; Nguyen,L.; Guo,L.; Jacobs,D. O.; Kuo,P. C.Little science, big science: strategies for research portfolio selection in academic surgery departments. Annals of Surgery 2007 ;246(6):1110-1115
Silva,H. T.,Jr; Yang,H. C.; Abouljoud,M.; Kuo,P. C.; Wisemandle,K.; Bhattacharya,P.; Dhadda,S.; Holman,J.; Fitzsimmons,W.; First,M. R.One-year results with extended-release tacrolimus/MMF, tacrolimus/MMF and cyclosporine/MMF in de novo kidney transplant recipients American Journal of Transplantation 2007 ;7(3):595-608
Reddy,S. K.; Marroquin,C. E.; Kuo,P. C.; Pappas,T. N.; Clary,B. M.Extended hepatic resection for gallbladder cancer. American Journal of Surgery 2007 ;194(3):355-361
Takami,Y.; Russell,M. B.; Gao,C.; Mi,Z.; Guo,H.; Mantyh,C. R.; Kuo,P. C.Sp1 regulates osteopontin expression in SW480 human colon adenocarcinoma cells. Surgery 2007 ;142(2):163-169
Wai,P. Y.; Guo,L.; Gao,C.; Mi,Z.; Guo,H.; Kuo,P. C.Osteopontin inhibits macrophage nitric oxide synthesis to enhance tumor proliferation. Surgery 2006 ;140(2):132-140
Wai,P. Y.; Mi,Z.; Gao,C.; Guo,H.; Marroquin,C.; Kuo,P. C.Ets-1 and runx2 regulate transcription of a metastatic gene, osteopontin, in murine colorectal cancer cells. Journal of Biological Chemistry 2006 ;281(28):18973-18982
Palmer,S. M.; Burch,L. H.; Mir,S.; Smith,S. R.; Kuo,P. C.; Herczyk,W. F.; Reinsmoen,N. L.; Schwartz,D. A.Donor polymorphisms in Toll-like receptor-4 influence the development of rejection after renal transplantation. Clinical transplantation 2006 ;20(1):30-36
Kuo,P. C.Clinical performance feedback is necessary but not sufficient for longterm success of the academic department of surgery. Journal of the American College of Surgeons 2006 ;203(3):402-403
Day,T. E.; Napoli,J. T.; Kuo,P. C.Scheduling the resident 80-hour work week: an operations research algorithm. Current surgery 2006 ;63(2):136-141
Desai,D. M.; Kuo,P. C.Who should perform liver transplantation? Should that be the transplant surgeon, the hepatobilary surgeon, or the general surgeon? Part I: the transplant surgeon. Journal of Hepatology 2006 ;44(4):647-649
Schroeder,R. A.; Marroquin,C. E.; Bute,B. P.; Khuri,S.; Henderson,W. G.; Kuo,P. C.Predictive indices of morbidity and mortality after liver resection. Annals of Surgery 2006 ;243(3):373-379
Gable,W. H.; Pappas,T. N.; Jacobs,D. O.; Cutler,D. A.; Kuo,P. C.Productivity measures associated with a patient access initiative. Annals of Surgery 2006 ;243(5):604-609
Mi,Z.; Guo,H.; Wai,P. Y.; Gao,C.; Kuo,P. C.Integrin-linked kinase regulates osteopontin-dependent MMP-2 and uPA expression to convey metastatic function in murine mammary epithelial cancer cells. Carcinogenesis 2006 ;27(6):1134-1145
Guo,H.; Gao,C.; Mi,Z.; Wai,P. Y.; Kuo,P. C.Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4alpha transcriptional activity. Biochemical Journal 2006 ;394(Pt 2):379-387
Guo,H.; Marroquin,C. E.; Wai,P. Y.; Kuo,P. C.Nitric oxide-dependent osteopontin expression induces metastatic behavior in HepG2 cells. Digestive Diseases & Sciences 2005 ;50(7):1288-1298
Hanish,S. I.; Petersen,R. P.; Collins,B. H.; Tuttle-Newhall,J.; Marroquin,C. E.; Kuo,P. C.; Butterly,D. W.; Smith,S. R.; Desai,D. M.Obesity predicts increased overall complications following pancreas transplantation. Transplantation proceedings 2005 ;37(8):3564-3566
Collins,B. H.; Marroquin,C. E.; Tuttle-Newhall,J. E.; Kuo,P. C.; Preminger,G. M.; Butterly,D. W.Acute kidney transplant failure following transurethral bladder polyp fulguration. Journal of the National Medical Association 2005 ;97(3):414-416
Desai,D. M.; Kuo,P. C.Perioperative management of special populations: immunocompromised host (cancer, HIV, transplantation) Surgical Clinics of North America 2005 ;85(6):1267-1282
Gao,C.; Guo,H.; Wei,J.; Mi,Z.; Wai,P. Y.; Kuo,P. C.Identification of S-nitrosylated proteins in endotoxin-stimulated RAW264.7 murine macrophages. Nitric Oxide 2005 ;12(2):121-126
Gao,C.; Guo,H.; Mi,Z.; Wai,P. Y.; Kuo,P. C.Transcriptional regulatory functions of heterogeneous nuclear ribonucleoprotein-U and -A/B in endotoxin-mediated macrophage expression of osteopontin. Journal of Immunology 2005 ;175(1):523-530
Smith,A. D.; Bai,D.; Marroquin,C. E.; Tuttle-Newhall,J. E.; Desai,D. M.; Collins,B. H.; Muir,A.; Kuo,P. C.; McHutchison,J.; Rockey,D. C.Gastrointestinal hemorrhage due to complicated gastroduodenal ulcer disease in liver transplant patients taking sirolimus. Clinical transplantation 2005 ;19(2):250-254
Smith,A. D.; Morse,M. A.; Kuo,P. C.Case 23-2005: a man with a mass in the liver. New England Journal of Medicine 2005 ;353(20):2195-2197
Marroquin,C. E.; Edwards,E. B.; Collins,B. H.; Desai,D. M.; Tuttle-Newhall,J. E.; Kuo,P. C.Half-life analysis of pancreas and kidney transplants. Transplantation 2005 ;80(2):272-275
Marroquin,C. E.; Wai,P. Y.; Kuo,P. C.; Guo,H.Redox-mediated upregulation of hepatocyte iNOS transcription requires coactivator PC4. Surgery 2005 ;138(1):93-99
Tuttle-Newhall,J. E.; Collins,B. H.; Desai,D. M.; Kuo,P. C.; Heneghan,M. A.The current status of living donor liver transplantation Current problems in surgery 2005 ;42(3):144-183
Wai,P. Y.; Mi,Z.; Guo,H.; Sarraf-Yazdi,S.; Gao,C.; Wei,J.; Marroquin,C. E.; Clary,B.; Kuo,P. C.Osteopontin silencing by small interfering RNA suppresses in vitro and in vivo CT26 murine colon adenocarcinoma metastasis. Carcinogenesis 2005 ;26(4):741-751
Mi,Z.; Guo,H.; Wai,P. Y.; Gao,C.; Wei,J.; Kuo,P. C.Differential osteopontin expression in phenotypically distinct subclones of murine breast cancer cells mediates metastatic behavior. Journal of Biological Chemistry 2004 ;279(45):46659-46667
Wai,P. Y.; Kuo,P. C.The role of Osteopontin in tumor metastasis Journal of Surgical Research 2004 ;121(2):228-241
Wei,J.; Guo,H.; Gao,C.; Kuo,P. C.Peroxide-mediated chromatin remodelling of a nuclear factor kappa B site in the mouse inducible nitric oxide synthase promoter. Biochemical Journal 2004 ;377(Pt 3):809-818
Gao,C.; Guo,H.; Wei,J.; Mi,Z.; Wai,P.; Kuo,P. C.S-nitrosylation of heterogeneous nuclear ribonucleoprotein A/B regulates osteopontin transcription in endotoxin-stimulated murine macrophages. Journal of Biological Chemistry 2004 ;279(12):11236-11243
Gao,C.; Mi,Z.; Guo,H.; Wei,J.; Wai,P. Y.; Kuo,P. C.A transcriptional repressor of osteopontin expression in the 4T1 murine breast cancer cell line. Biochemical & Biophysical Research Communications 2004 ;321(4):1010-1016
Huang,E. S.; Nevins,J. R.; West,M.; Kuo,P. C.An overview of genomic data analysis. Surgery 2004 ;136(3):497-499
Marroquin,C. E.; Downey,L.; Guo,H.; Kuo,P. C.Osteopontin increases CD44 expression and cell adhesion in RAW 264.7 murine leukemia cells. Immunology letters 2004 ;95(1):109-112
Kuo,P. C.; Douglas,A. R.; Oleski,D.; Jacobs,D. O.; Schroeder,R. A.Determining benchmarks for evaluation and management coding in an academic division of general surgery. Journal of the American College of Surgeons 2004 ;199(1):124-130
Schroeder,R. A.; Collins,B. H.; Tuttle-Newhall,E.; Robertson,K.; Plotkin,J.; Johnson,L. B.; Kuo,P. C.Intraoperative fluid management during orthotopic liver transplantation. Journal of Cardiothoracic & Vascular Anesthesia 2004 ;18(4):438-441
Heneghan,M. A.; Tuttle-Newhall,J. E.; Suhocki,P. V.; Muir,A. J.; Morse,M.; Bornstein,J. D.; Sylvestre,P. B.; Collins,B.; Kuo,P. C.; Rockey,D. C.De-novo cholangiocarcinoma in the setting of recurrent primary sclerosing cholangitis following liver transplant. American Journal of Transplantation 2003 ;3(5):634-638
Kuo,P. C.; Schroeder,R. A.; Mahaffey,S.; Bollinger,R. R.Optimization of operating room allocation using linear programming techniques. Journal of the American College of Surgeons 2003 ;197(6):889-895
Rocha,P. N.; Butterly,D. W.; Greenberg,A.; Reddan,D. N.; Tuttle-Newhall,J.; Collins,B. H.; Kuo,P. C.; Reinsmoen,N.; Fields,T.; Howell,D. N.; Smith,S. R.Beneficial effect of plasmapheresis and intravenous immunoglobulin on renal allograft survival of patients with acute humoral rejection. Transplantation 2003 ;75(9):1490-1495
Tuttle-Newhall,J. E.; Collins,B. H.; Kuo,P. C.; Schoeder,R.Organ donation and treatment of the multi-organ donor Current problems in surgery 2003 ;40(5):266-310
Schroeder,R. A.; Marroquin,C. E.; Kuo,P. C.Tolerance and the "Holy Grail" of transplantation Journal of Surgical Research 2003 ;111(1):109-119
Gao,C.; Guo,H.; Downey,L.; Marroquin,C.; Wei,J.; Kuo,P. C.Osteopontin-dependent CD44v6 expression and cell adhesion in HepG2 cells. Carcinogenesis 2003 ;24(12):1871-1878
Gao,C.; Guo,H.; Wei,J.; Kuo,P. C.Osteopontin inhibits expression of cytochrome c oxidase in RAW 264.7 murine macrophages. Biochemical & Biophysical Research Communications 2003 ;309(1):120-125
Marroquin,C. E.; Tuttle-Newhall,J. E.; Collins,B. H.; Kuo,P. C.; Schroeder,R. A.Emergencies after liver transplantation. Seminars in gastrointestinal disease 2003 ;14(2):101-110
Dy-Liacco,M. S.; Tuttle-Newhall,E. J.; Collins,B. H.; Kuo,P. C.Liver transplantation from a cadaver donor with ethylene-glycol-induced brain death. Transplantation 2003 ;75(7):1056
Guo,H.; Wei,J.; Inoue,Y.; Gonzalez,F. J.; Kuo,P. C.Serine/threonine phosphorylation regulates HNF-4alpha-dependent redox-mediated iNOS expression in hepatocytes. American Journal of Physiology - Cell Physiology 2003 ;284(4):1090-1099
Guo,H.; Cai,C. Q.; Kuo,P. C.Hepatocyte nuclear factor-4alpha mediates redox sensitivity of inducible nitric-oxide synthase gene transcription. Journal of Biological Chemistry 2002 ;277(7):5054-5060
Buell,J. F.; Hanaway,M. J.; Potter,S. R.; Koffron,A.; Kuo,P. C.; Leventhal,J.; Cho,E.; Johnson,M.; Edye,M.; Woodle,E. S.Surgical techniques in right laparoscopic donor nephrectomy. Journal of the American College of Surgeons 2002 ;195(1):131-137
Jha,R. C.; Korangy,S. J.; Ascher,S. M.; Takahama,J.; Kuo,P. C.; Johnson,L. B.MR angiography and preoperative evaluation for laparoscopic donor nephrectomy. AJR.American Journal of Roentgenology 2002 ;178(6):1489-1495
Marino,G.; Rustgi,V. K.; Salzberg,G.; Johnson,L. B.; Kuo,P. C.; Plotkin,J. S.; Flockhart,D. A.Pharmacokinetics and biochemical effects of hepapoietin in patients with chronic liver disease. Alimentary Pharmacology & Therapeutics 2002 ;16(2):235-242
Muir,A. J.; Sanders,L. L.; Heneghan,M. A.; Kuo,P. C.; Wilkinson,W. E.; Provenzale,D.An examination of factors predicting prioritization for liver transplantation. Liver Transplantation 2002 ;8(10):957-961
Wei,J.; Guo,H.; Kuo,P. C.Endotoxin-stimulated nitric oxide production inhibits expression of cytochrome c oxidase in ANA-1 murine macrophages. Journal of Immunology 2002 ;168(9):4721-4727
Guo,H. T.; Cai,C. Q.; Schroeder,R. A.; Kuo,P. C.Nitric oxide is necessary for CC-class chemokine expression in endotoxin-stimulated ANA-1 murine macrophages. Immunology letters 2002 ;80(1):21-26
Wai,P. H.; Ewing,C. A.; Johnson,L. B.; Lu,A. D.; Attinger,C.; Kuo,P. C.Candida fasciitis following renal transplantation Transplantation 2001 ;72(3):477-479
Kuo,P. C.; Stock,P. G.Transplantation in the HIV+ patient American Journal of Transplantation 2001 ;1(1):13-17
Kuo,P. C.; Lu,A. D.; Johnson,L. B.Expanded criteria donors/high risk recipients is not always cheaper than hemodialysis. Transplantation 2001 ;72(3):554-555
Kuo,P. C.Reconsideration of HIV as a contraindication to transplantation. Transplantation 2001 ;71(11):1689
Plotkin,J. S.; Johnson,L. B.; Rustgi,V. K.; Kuo,P. C.; Lu,A. D.Dobutamine stress echocardiography for orthotopic liver transplant evaluation. Transplantation 2001 ;71(6):818
Buell,J. F.; Edye,M.; Johnson,M.; Li,C.; Koffron,A.; Cho,E.; Kuo,P.; Johnson,L.; Hanaway,M.; Potter,S. R.; Bruce,D. S.; Cronin,D. C.; Newell,K. A.; Leventhal,J.; Jacobs,S.; Woodle,E. S.; Bartlett,S. T.; Flowers,J. L.Are concerns over right laparoscopic donor nephrectomy unwarranted?. Annals of Surgery 2001 ;233(5):645-651
Cappadonna,C. R.; Johnson,L. B.; Lu,A. D.; Kuo,P. C.Outcome of extra-anatomic vascular reconstruction in orthotopic liver transplantation. American Journal of Surgery 2001 ;182(2):147-150
Marroquin,C. E.; Marino,G.; Kuo,P. C.; Plotkin,J. S.; Rustgi,V. K.; Lu,A. D.; Edwards,E.; Taranto,S.; Johnson,L. B.Transplantation of hepatitis C-positive livers in hepatitis C-positive patients is equivalent to transplanting hepatitis C-negative livers. Liver Transplantation 2001 ;7(9):762-768
Guo,H.; Cai,C. Q.; Schroeder,R. A.; Kuo,P. C.Osteopontin is a negative feedback regulator of nitric oxide synthesis in murine macrophages. Journal of Immunology 2001 ;166(2):1079-1086
Guo,H.; Wei,J.; Kuo,P. C.Nitric oxide inhibits expression of cytochrome B in endotoxin-stimulated murine macrophages. Biochemical & Biophysical Research Communications 2001 ;289(5):993-997
Guo,H. T.; Cai,C. Q.; Kuo,P. C.Endotoxin and NO induce MIP-1gamma gene transcription in ANA-1 murine macrophages. Biochemical & Biophysical Research Communications 2000 ;277(3):617-621
Kuo,P. C.; Abe,K.; Schroeder,R. A.Superoxide enhances interleukin 1beta-mediated transcription of the hepatocyte-inducible nitric oxide synthase gene Gastroenterology 2000 ;118(3):608-618