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RESEARCH FOCUS AREAS:
- Keratinocyte and melanocyte biology
- Ultraviolet radiation induced skin carcinogenesis
- Protein kinase C signaling
RESEARCH SUMMARY:
Our laboratory is interested in understanding the regulation of cell fate decisions (proliferation, differentiation, death) for keratinocytes and melanocytes within the normal epidermis, as well as how these processes become perturbed during ultraviolet radiation-induced skin carcinogenesis. We are focused on protein kinase C signaling pathways as key regulators of epidermal biology, and use a variety of molecular, biochemical and cell biological approaches to uncover novel signaling mechanisms. The cellular responses to ultraviolet radiation are complex, and we are interested in the multitude of biological effects elicited by UV radiation, including inflammation, cell cycle arrest, DNA damage repair and cell death. By understating both physiological and pathological regulatory mechanisms in the epidermis, we are able to test novel preventive and therapeutic approaches to combat the approximately 4.5 million new cases of skin cancers diagnosed annually in the USA.
EDUCATION:
- BS in Biochemistry, University of Arizona
- PhD in Human Cancer Biology, University of Wisconsin-Madison
- Postdoctoral fellowship in Skin Carcinogenesis, National Cancer Institute, National Institutes of Health
- Postdoctoral fellowship in Cell-Cell Adhesion, Northwestern University
SELECT PUBLICATIONS:
- Ripk3 signaling regulates HSCs during stress and represses radiation-induced leukemia in mice Zhang, L; Luo, H; Ni, HM; Liu, S; Xing, H; Zhang, J; Sellin, M; Breslin, S J P; Wei, W; Denning, MF; Small, W Jr; Ding, WX; Huang, S; Zhang, J Stem Cell Reports 2022 Jun 14;17(6):1428-1441. doi: 10.1016/j.stemcr.2022.04.009. Epub 2022 May 12. PMID: 35561683; PMCID: PMC9213819
- RIPK3 signaling and its role in the pathogenesis of cancers Liu, S; Joshi, K; Denning, MF; Zhang, J Cellular and Molecular Life Sciences 2021 Dec;78(23):7199-7217. doi: 10.1007/s00018-021-03947-y. Epub 2021 Oct 15. PMID: 34654937; PMCID: PMC9044760
- Targeting EphA2 suppresses hepatocellular carcinoma initiation and progression by dual inhibition of JAK1/STAT3 and AKT signaling Wang, H; Hou, W; Perera, A; Bettler, C; Beach, JR; Ding, X; Li, J; Denning, MF; Dhanarajan, A; Cotler, SJ; Joyce, C; Yin, J; Ahmed, F; Roberts, LR; Qiu ,W Cell Reports 2021 Feb 23;34(8):108765. doi: 10.1016/j.celrep.2021.108765. PMID: 33626345; PMCID: PMC7954228
- ABL1, overexpressed in hepatocellular carcinomas, regulates expression of NOTCH1 and promotes development of liver tumors in mice Wang, F; Hou, W; Chitsike, L; Xu, Y; Bettler, C; Perera, A; Bank, T; Cotler, SJ; Dhanarajan, A; Denning, MF; Ding, X; Breslin, P; Qiang, W; Li, J; Koleske, AJ; Qiu, W Gastroenterology 2020 Jul;159(1):289-305.e16. doi: 10.1053/j.gastro.2020.03.013. Epub 2020 Jun 24. PMID: 32171747; PMCID: PMC7387191
- Inhibition of insulin-like growth factor 1 receptor enhances the efficacy of sorafenib in inhibiting hepatocellular carcinoma cell growth and survival Wang, F; Bank, T; Malnassy, G; Arteaga, M; Shang, N; Dalheim, A; Ding, X; Cotler, SJ; Denning, MF; Nishimura, MI; Breslin, P; Qiu, W Hepatology Communications 2018 Apr 17;2(6):732-746. doi: 10.1002/hep4.1181. PMID: 29881824; PMCID: PMC5983153
- The role of Rak in the regulation of stability and function of BRCA1 Kim, JL; Ha, GH; Campo, L; Denning, MF; Patel, TB; Osipo, C; Lin, SY; Breuer, EK Oncotarget 2015 Oct 14;8(49):86799-86815. doi: 10.18632/oncotarget.5717. PMID: 29156836; PMCID: PMC5689726.
- PKC-dependent regulation of Kv7.5 channels by the bronchoconstrictor histamine in human airway smooth muscle cells Haick, JM; Brueggemann, LI; Cribbs, LL; Denning, MF; Schwartz, J; Byron, KL American Journal of Physiology - Lung Cellular and Molecular Physiology 2017 Jun 1;312(6):L822-L834. doi: 10.1152/ajplung.00567.2016. Epub 2017 Mar 10. PMID: 28283479
- Inhibition of SIRT2 suppresses hepatic fibrosis Arteaga, M; Shang, N; Ding, X; Yong, S; Cotler, SJ; Denning, MF; Shimamura, T; Breslin, P; Lüscher, B; Qiu, W American Journal of Physiology – Gastrointestinal and Liver Physiology 2016 Jun 1;310(11):G1155-68. doi: 10.1152/ajpgi.00271.2015. Epub 2016 Apr 28. PMID: 27125275; PMCID: PMC4935480
- PKCα attenuates Jagged-1-mediated Notch signaling in ErbB-2-positive breast cancer to reverse trastuzumab resistance Pandya, K; Wyatt, D; Gallagher, B; Shah, D; Baker, A; Bloodworth, J; Zlobin, A; Pannuti, A; Green, A; Ellis, IO; Filipovic, A; Sagert, J; Rana, A; Albain, KS; Miele, L; Denning, MF; Osipo, C Clinical Cancer Research 2016 Jan 1;22(1):175-86. doi: 10.1158/1078-0432.CCR-15-0179. Epub 2015 Sep 8. PMID: 26350262; PMCID: PMC4703529
- Targeting Fyn in Ras-transformed cells induces F-actin to promote adherens junction-mediated cell-cell adhesion Fenton, SE; Hutchens, KA; Denning, MF Molecular Carcinogenesis 2015 Oct;54(10):1181-93. doi: 10.1002/mc.22190. Epub 2014 Jun 29. PMID: 24976598
Mitchell Denning Publication List
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