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Allen Samarel
Professor Emeritus
Primary Department
Joint Department
Cell and Molecular Physiology
Cardiac Rehabilitation
Congestive Heart Failure
Medical School
Harvard Medical School
Mount Sinai Medical Center, Internal Medicine: General
Northwestern University McGaw Medical Center, Cardiology
Northwestern University McGaw Medical Center, Cardiology
Cardiovascular System
Excitation-Contraction coupling
Gene Regulation
Tissue Engineering
Vascular Biology
Gene Therapy
Recombinant DNA
Signal Transduction
Thyroid Functions
Zak,T. J.; Koshman,Y. E.; Samarel,A. M.; Robia,S. L.Regulation of Focal Adhesion Kinase through a Direct Interaction with an Endogenous Inhibitor Biochemistry 2017 ;56(35):4722-4731
Kotlo,K.; Samarel,A. M.; Chen,H. Y.; Aldstadt,J.; Danziger,R. S.Global comparison of phosphoproteins in human and rodent hearts: implications for translational studies of myosin light chain and troponin phosphorylations SpringerPlus 2016 ;5(1):808-016-2469-x. eCollection 2016
Glasgow,J.; Koshman,Y.; Samarel,A. M.; Tseng,K. Y.; Scrogin,K.Myocardial infarction sensitizes medial prefrontal cortex to inhibitory effect of locus coeruleus stimulation in rats Psychopharmacology 2016 ; :
Pabbidi,M. R.; Ji,X.; Maxwell,J. T.; Mignery,G. A.; Samarel,A. M.; Lipsius,S. L.Inhibition of cAMP-Dependent PKA Activates beta2-Adrenergic Receptor Stimulation of Cytosolic Phospholipase A2 via Raf-1/MEK/ERK and IP3-Dependent Ca2+ Signaling in Atrial Myocytes PLoS ONE 2016 ;11(12):e0168505
Koshman,Y. E.; Sternlicht,M. D.; Kim,T.; O'Hara,C. P.; Koczor,C. A.; Lewis,W.; Seeley,T. W.; Lipson,K. E.; Samarel,A. M.Connective tissue growth factor regulates cardiac function and tissue remodeling in a mouse model of dilated cardiomyopathy Journal of Molecular and Cellular Cardiology 2015 ;89(Pt B):214-222
Mylroie,H.; Dumont,O.; Bauer,A.; Thornton,C. C.; Mackey,J.; Calay,D.; Hamdulay,S. S.; Choo,J. R.; Boyle,J. J.; Samarel,A. M.; Randi,A. M.; Evans,P. C.; Mason,J. C.PKCepsilon-CREB-Nrf2 signalling induces HO-1 in the vascular endothelium and enhances resistance to inflammation and apoptosis Cardiovascular research 2015 ;106(3):509-519
Koshman,Y. E.; Chu,M.; Kim,T.; Kalmanson,O.; Farjah,M.; Kumar,M.; Lewis,W.; Geenen,D. L.; de Tombe,P.; Goldspink,P. H.; Solaro,R. J.; Samarel,A. M.Cardiomyocyte-specific expression of CRNK, the C-terminal domain of PYK2, maintains ventricular function and slows ventricular remodeling in a mouse model of dilated cardiomyopathy Journal of Molecular and Cellular Cardiology 2014 ;72C:281-291
Samarel,A. M.Focal adhesion signaling in heart failure Pflugers Archiv : European journal of physiology 2014 ;466(6):1101-1111
Henze,M.; Tiniakov,R.; Samarel,A.; Holmes,E.; Scrogin,K.Chronic fluoxetine reduces autonomic control of cardiac rhythms in rats with congestive heart failure American journal of physiology.Heart and circulatory physiology 2013 ;304(3):H444-54
Koshman,Y. E.; Patel,N.; Chu,M.; Iyengar,R.; Kim,T.; Ersahin,C.; Lewis,W.; Heroux,A.; Samarel,A. M.Regulation of connective tissue growth factor gene expression and fibrosis in human heart failure Journal of cardiac failure 2013 ;19(4):283-294
Puglisi,J. L.; Yuan,W.; Timofeyev,V.; Myers,R. E.; Chiamvimonvat,N.; Samarel,A. M.; Bers,D. M.Phorbol ester and endothelin-1 alter functional expression of Na+/Ca2+ exchange, K+, and Ca2+ currents in cultured neonatal rat myocytes. American Journal of Physiology - Heart & Circulatory Physiology 2011 ;300(2):H617-26
Koshman,Y. E.; Chu,M.; Engman,S. J.; Kim,T.; Iyengar,R.; Robia,S. L.; Samarel,A. M.Focal adhesion kinase-related nonkinase inhibits vascular smooth muscle cell invasion by focal adhesion targeting, tyrosine 168 phosphorylation, and competition for p130(Cas) binding. Arteriosclerosis, Thrombosis & Vascular Biology 2011 ;31(11):2432-2440
Russell,B.; Curtis,M. W.; Koshman,Y. E.; Samarel,A. M.Mechanical stress-induced sarcomere assembly for cardiac muscle growth in length and width Journal of Molecular and Cellular Cardiology 2010 ;48(5):817
Koshman,Y. E.; Engman,S. J.; Kim,T.; Iyengar,R.; Henderson,K. K.; Samarel,A. M.Role of FRNK tyrosine phosphorylation in vascular smooth muscle spreading and migration. Cardiovascular research 2010 ;85(3):571-581
Koshman,Y. E.; Kim,T.; Chu,M.; Engman,S. J.; Iyengar,R.; Robia,S. L.; Samarel,A. M.FRNK inhibition of focal adhesion kinase-dependent signaling and migration in vascular smooth muscle cells. Arteriosclerosis, Thrombosis & Vascular Biology 2010 ;30(11):2226-2233
Brewster,L. P.; Ucuzian,A. A.; Brey,E. M.; Liwanag,M.; Samarel,A. M.; Greisler,H. P.FRNK overexpression limits the depth and frequency of vascular smooth muscle cell invasion in a three-dimensional fibrin matrix. Journal of cellular physiology 2010 ;225(2):562-568
Hartman,T. J.; Martin,J. L.; Solaro,R. J.; Samarel,A. M.; Russell,B.CapZ dynamics are altered by endothelin-1 and phenylephrine via PIP2- and PKC-dependent mechanisms. American Journal of Physiology - Cell Physiology 2009 ;296(5):1034-1039
Henderson,K. K.; Danzi,S.; Paul,J. T.; Leya,G.; Klein,I.; Samarel,A. M.Physiological replacement of T3 improves left ventricular function in an animal model of myocardial infarction-induced congestive heart failure. Circulation: Heart Failure 2009 ;2(3):243-252
Wang,Y. G.; Ji,X.; Pabbidi,M.; Samarel,A. M.; Lipsius,S. L.Laminin acts via focal adhesion kinase/phosphatidylinositol-3' kinase/protein kinase B to down-regulate beta1-adrenergic receptor signalling in cat atrial myocytes. Journal of Physiology 2009 ;587(Pt 3):541-550
Pabbidi,M. R.; Ji,X.; Samarel,A. M.; Lipsius,S. L.Laminin enhances beta(2)-adrenergic receptor stimulation of L-type Ca(2+) current via cytosolic phospholipase A(2) signalling in cat atrial myocytes. Journal of Physiology 2009 ;587(Pt 20):4785-4797
Khare,S.; Mustafi,R.; Cerda,S.; Yuan,W.; Jagadeeswaran,S.; Dougherty,U.; Tretiakova,M.; Samarel,A.; Cohen,G.; Wang,J.; Moore,C.; Wali,R.; Holgren,C.; Joseph,L.; Fichera,A.; Li,Y. C.; Bissonnette,M.Ursodeoxycholic acid suppresses Cox-2 expression in colon cancer: roles of Ras, p38, and CCAAT/enhancer-binding protein. Nutrition & Cancer 2008 ;60(3):389-400
Samarel,A. M.PICOT: a multidomain scaffolding inhibitor of hypertrophic signal transduction. Circulation research 2008 ;102(6):625-627
Hart,D. L.; Heidkamp,M. C.; Iyengar,R.; Vijayan,K.; Szotek,E. L.; Barakat,J. A.; Leya,M.; Henze,M.; Scrogin,K.; Henderson,K. K.; Samarel,A. M.CRNK gene transfer improves function and reverses the myosin heavy chain isoenzyme switch during post-myocardial infarction left ventricular remodeling. Journal of Molecular & Cellular Cardiology 2008 ;45(1):93-105
Henze,M.; Hart,D.; Samarel,A.; Barakat,J.; Eckert,L.; Scrogin,K.Persistent alterations in heart rate variability, baroreflex sensitivity, and anxiety-like behaviors during development of heart failure in the rat American Journal of Physiology - Heart & Circulatory Physiology 2008 ;295(1):H29-38
Fernandez,A.; Sanguino,A.; Peng,Z.; Ozturk,E.; Chen,J.; Crespo,A.; Wulf,S.; Shavrin,A.; Qin,C.; Ma,J.; Trent,J.; Lin,Y.; Han,H. D.; Mangala,L. S.; Bankson,J. A.; Gelovani,J.; Samarel,A.; Bornmann,W.; Sood,A. K.; Lopez-Berestein,G.An anticancer C-Kit kinase inhibitor is reengineered to make it more active and less cardiotoxic. Journal of Clinical Investigation 2007 ;117(12):4044-4054
Burgos,M.; Calvo,S.; Molina,F.; Vaquero,C. F.; Samarel,A.; Llopis,J.; Tranque,P.PKCepsilon induces astrocyte stellation by modulating multiple cytoskeletal proteins and interacting with Rho A signalling pathways: implications for neuroinflammation. European Journal of Neuroscience 2007 ;25(4):1069-1078
Steinberg,R.; Harari,O. A.; Lidington,E. A.; Boyle,J. J.; Nohadani,M.; Samarel,A. M.; Ohba,M.; Haskard,D. O.; Mason,J. C.A protein kinase Cepsilon-anti-apoptotic kinase signaling complex protects human vascular endothelial cells against apoptosis through induction of Bcl-2. Journal of Biological Chemistry 2007 ;282(44):32288-32297
Dedkova,E. N.; Wang,Y. G.; Ji,X.; Blatter,L. A.; Samarel,A. M.; Lipsius,S. L.Signalling mechanisms in contraction-mediated stimulation of intracellular NO production in cat ventricular myocytes. Journal of Physiology 2007 ;580(Pt 1):327-345
Heidkamp,M. C.; Iyengar,R.; Szotek,E. L.; Cribbs,L. L.; Samarel,A. M.Protein kinase Cepsilon-dependent MARCKS phosphorylation in neonatal and adult rat ventricular myocytes. Journal of Molecular & Cellular Cardiology 2007 ;42(2):422-431
Khare,S.; Holgren,C.; Samarel,A. M.Deoxycholic acid differentially regulates focal adhesion kinase phosphorylation: role of tyrosine phosphatase ShP2. American Journal of Physiology - Gastrointestinal & Liver Physiology 2006 ;291(6):G1100-12
Holinstat,M.; Knezevic,N.; Broman,M.; Samarel,A. M.; Malik,A. B.; Mehta,D.Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeability. Journal of Biological Chemistry 2006 ;281(4):2296-2305
Blum,J. L.; Samarel,A. M.; Mestril,R.Phosphorylation and binding of AUF1 to the 3'-untranslated region of cardiomyocyte SERCA2a mRNA. American Journal of Physiology - Heart & Circulatory Physiology 2005 ;289(6):H2543-50
Heidkamp,M. C.; Scully,B. T.; Vijayan,K.; Engman,S. J.; Szotek,E. L.; Samarel,A. M.PYK2 regulates SERCA2 gene expression in neonatal rat ventricular myocytes. American Journal of Physiology - Cell Physiology 2005 ;289(2):471-482
Samarel,A. M.Costameres, focal adhesions, and cardiomyocyte mechanotransduction American Journal of Physiology - Heart & Circulatory Physiology 2005 ;289(6):H2291-301
Vijayan,K.; Szotek,E. L.; Martin,J. L.; Samarel,A. M.Protein kinase C-alpha-induced hypertrophy of neonatal rat ventricular myocytes. American Journal of Physiology - Heart & Circulatory Physiology 2004 ;287(6):H2777-89
Bayer,A. L.; Heidkamp,M. C.; Howes,A. L.; Heller Brown,J.; Byron,K. L.; Samarel,A. M.Protein kinase C epsilon-dependent activation of proline-rich tyrosine kinase 2 in neonatal rat ventricular myocytes. Journal of Molecular & Cellular Cardiology 2003 ;35(9):1121-1133
Bayer,A. L.; Heidkamp,M. C.; Patel,N.; Porter,M.; Engman,S.; Samarel,A. M.Alterations in protein kinase C isoenzyme expression and autophosphorylation during the progression of pressure overload-induced left ventricular hypertrophy. Molecular & Cellular Biochemistry 2003 ;242(1-2):145-152
Porter,M. J.; Heidkamp,M. C.; Scully,B. T.; Patel,N.; Martin,J. L.; Samarel,A. M.Isoenzyme-selective regulation of SERCA2 gene expression by protein kinase C in neonatal rat ventricular myocytes American Journal of Physiology - Cell Physiology 2003 ;285(1):39-47
Heidkamp,M. C.; Bayer,A. L.; Scully,B. T.; Eble,D. M.; Samarel,A. M.Activation of focal adhesion kinase by protein kinase C epsilon in neonatal rat ventricular myocytes. American Journal of Physiology - Heart & Circulatory Physiology 2003 ;285(4):H1684-96