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Gail Hecht
Primary Department
Joint Department
Microbiology and Immunology
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Loyola Outpatient Center
American Board of Internal Medicine Subspecialty Gastroenterology
American Board of Internal Medicine
Medical School
Loyola University Chicago Stritch School of Medicine
University of Minnesota Hospital and Clinics, Internal Medicine
Brigham and Women's Hospital/Harvard Medical School, Gastroenterology
The focus of Dr. Hecht’s research is host-pathogen interactions with specific emphasis on enteropathogenic Escherichia coli and enterohemorrhagic E. coli. Her goal is to determine how the bacterial effector proteins that are translocated into intestinal epithelial cells by these pathogens alter host cell physiology including tight junction barrier function, active ion transport processes, and the innate immune response. Her research is funded by both the NIH and the VA. She also has an interest in the gut microbiome and its impact on intestinal function and health.
Kralicek,S. E.; Nguyen,M.; Rhee,K. J.; Tapia,R.; Hecht,G.EPEC NleH1 is significantly more effective in reversing colitis and reducing mortality than NleH2 via differential effects on host signaling pathways Laboratory investigation; a journal of technical methods and pathology 2018 ; :
Dubberke, ER; Lee, CH; Orenstein, R; Khanna, S; Hecht, G; Gerding, DNResults from a Randomized Placebo-Controlled Clinical Trial of a RBX2660-a Microbiota-based Drug for the Prevention of Recurrent Clostridium difficile Infection. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2018 ;
Tapia,R.; Kralicek,S. E.; Hecht,G. A.Modulation of epithelial cell polarity by bacterial pathogens Annals of the New York Academy of Sciences 2017 ; :
Singhal,M.; Manzella,C.; Soni,V.; Alrefai,W. A.; Saksena,S.; Hecht,G. A.; Dudeja,P. K.; Gill,R. K.Role of SHP2 protein tyrosine phosphatase in SERT inhibition by enteropathogenic E. coli (EPEC) American journal of physiology.Gastrointestinal and liver physiology 2017 ;312(5):G443-G449
Tapia,R.; Kralicek,S. E.; Hecht,G. A.EPEC effector EspF promotes Crumbs3 endocytosis and disrupts epithelial cell polarity Cellular microbiology 2017 ; :
Eppinga,H.; Fuhler,G. M.; Peppelenbosch,M. P.; Hecht,G. A.Gut Microbiota Developments With Emphasis on Inflammatory Bowel Disease: Report From the Gut Microbiota for Health World Summit 2016 Gastroenterology 2016 ; :
Nguyen,M.; Rizvi,J.; Hecht,G.Expression of enteropathogenic Escherichia coli map is significantly different than that of other type III secreted effectors in vivo INFECTION AND IMMUNITY 2015 ;83(1):130-137
Gujral,T.; Kumar,A.; Priyamvada,S.; Saksena,S.; Gill,R. K.; Hodges,K.; Alrefai,W. A.; Hecht,G. A.; Dudeja,P. K.Mechanisms of DRA recycling in intestinal epithelial cells: effect of enteropathogenic E. coli American journal of physiology.Cell physiology 2015 ;309(12):C835-C846
Hecht,G. A.; Blaser,M. J.; Gordon,J.; Kaplan,L. M.; Knight,R.; Laine,L.; Peek,R.; Sanders,M. E.; Sartor,B.; Wu,G. D.; Yang,V. W.What is the value of a food and drug administration investigational new drug application for fecal microbiota transplantation to treat Clostridium difficile Infection? Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2014 ;12(2):289-291
Hecht,G.AGA's approach to the microbiome Gastroenterology 2014 ;146(4):1119-1121
Battle,S. E.; Brady,M. J.; Vanaja,S. K.; Leong,J. M.; Hecht,G. A.Actin pedestal formation by enterohemorrhagic Escherichia coli enhances bacterial host cell attachment and concomitant type III translocation INFECTION AND IMMUNITY 2014 ;82(9):3713-3722
Glotfelty,L. A.; Zahs,A.; Iancu,C.; Shen,L.; Hecht,G. A.Microtubules Are Required for Efficient Epithelial Tight Junction Homeostasis and Restoration American journal of physiology.Cell physiology 2014 ;307(3):C245-C254
Glotfelty,L. G.; Zahs,A.; Hodges,K.; Shan,K.; Alto,N. M.; Hecht,G. A.Enteropathogenic E. coli effectors EspG1/G2 disrupt microtubules, contribute to tight junction perturbation and inhibit restoration Cellular microbiology 2014 ;16(12):1767-1783
Hodges,K.; Hecht,G.Bacterial infections of the small intestine CURRENT OPINION IN GASTROENTEROLOGY 2013 ;29(2):159-163
Hodges,K.; Hecht,G.Interspecies communication in the gut, from bacterial delivery to host-cell response The Journal of physiology 2012 ;590(Pt 3):433-440