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I. Caroline LePoole Photo
Name
I. Caroline LePoole
Degree
Ph.D.
Rank
Professor
Primary Department
Pathology
Joint Department
Microbiology and Immunology
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Education
Advanced Degrees
University of Amsterdam , Amsterdam , FR , The Netherlands
Keywords
Autoimmunity
Tumor Immunology
Publications
Eby,J. M.; Barse,L.; Henning,S. W.; Rabelink,M. J.; Klarquist,J.; Gilbert,E. R.; Hammer,A. M.; Fernandez,M. F.; Yung,N.; Khan,S.; Miller,H. G.; Kessler,E. R.; Garrett-Mayer,E.; Dilling,D. F.; Hoeben,R. C.; Le Poole,I. C.Alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 can support immune responses toward tumors overexpressing ganglioside D3 in mice Cancer immunology, immunotherapy : CII 2017 ;66(1):63-75
Klarquist,J.; Eby,J. M.; Henning,S. W.; Li,M.; Wainwright,D. A.; Westerhof,W.; Luiten,R. M.; Nishimura,M. I.; Le Poole,I. C.Functional cloning of a gp100-reactive T-cell receptor from vitiligo patient skin Pigment Cell & Melanoma Research 2016 ;29(3):379-384
Klarquist,J.; Tobin,K.; Farhangi Oskuei,P.; Henning,S. W.; Fernandez,M. F.; Dellacecca,E. R.; Navarro,F. C.; Eby,J. M.; Chatterjee,S.; Mehrotra,S.; Clark,J. I.; Le Poole,I. C.Ccl22 Diverts T Regulatory Cells and Controls the Growth of Melanoma Cancer research 2016 ; :
Webb,K. C.; Tung,R.; Winterfield,L. S.; Gottlieb,A. B.; Eby,J. M.; Henning,S. W.; Le Poole,I. C.TNF-alpha inhibition can stabilize disease in progressive vitiligo The British journal of dermatology 2015 ;173(3):641-650
Webb,K. C.; Tung,R.; Winterfield,L. S.; Gottlieb,A. B.; Eby,J. M.; Henning,S. W.; Le Poole,I. C.Tumour necrosis factor-alpha inhibition can stabilize disease in progressive vitiligo The British journal of dermatology 2015 ; :
Mosenson,J. A.; Flood,K.; Klarquist,J.; Eby,J. M.; Koshoffer,A.; Boissy,R. E.; Overbeck,A.; Tung,R. C.; Le Poole,I. C.Preferential secretion of inducible HSP70 by vitiligo melanocytes under stress Pigment Cell & Melanoma Research 2014 ;27(2):209-220
Tung,R.; Le Poole,I. C.Vitiligo treatment demystified: a flowchart for stratified treatment approaches Experimental dermatology 2014 ;23(7):469-470
Bonchak,J. G.; Eby,J. M.; Willenborg,K. A.; Chrobak,D.; Henning,S. W.; Krzywiec,A.; Johnson,S. L.; Le Poole,I. C.Targeting melanocyte and melanoma stem cells by 8-hydroxy-2-dipropylaminotetralin ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 2014 ;563:71-78
Mehta,V.; Venkataraman,G.; Antic,T.; Rubinas,T. C.; Le Poole,I. C.; Picken,M. M.Renal angiomyolipoma, fat-poor variant--a clinicopathologic mimicker of malignancy Virchows Archiv : an international journal of pathology 2013 ;463(1):41-46
Mosenson,J. A.; Zloza,A.; Nieland,J. D.; Garrett-Mayer,E.; Eby,J. M.; Huelsmann,E. J.; Kumar,P.; Denman,C. J.; Lacek,A. T.; Kohlhapp,F. J.; Alamiri,A.; Hughes,T.; Bines,S. D.; Kaufman,H. L.; Overbeck,A.; Mehrotra,S.; Hernandez,C.; Nishimura,M. I.; Guevara-Patino,J. A.; Le Poole,I. C.Mutant HSP70 reverses autoimmune depigmentation in vitiligo Science translational medicine 2013 ;5(174):174ra28
Mosenson,J. A.; Eby,J. M.; Hernandez,C.; Le Poole,I. C.A central role for inducible heat-shock protein 70 in autoimmune vitiligo Experimental dermatology 2013 ;22(9):566-569
Gilbert,E. R.; Eby,J. M.; Hammer,A. M.; Klarquist,J.; Christensen,D. G.; Barfuss,A. J.; Boissy,R. E.; Picken,M. M.; Love,R. B.; Dilling,D. F.; Le Poole,I. C.Positioning ganglioside D3 as an immunotherapeutic target in lymphangioleiomyomatosis The American journal of pathology 2013 ;183(1):226-234
Dilling,D. F.; Gilbert,E. R.; Picken,M. M.; Eby,J. M.; Love,R. B.; Le Poole,I. C.A current viewpoint of lymphangioleiomyomatosis supporting immunotherapeutic treatment options American Journal of Respiratory Cell & Molecular Biology 2012 ;46(1):1-5
Ezzedine,K.; Lim,H. W.; Suzuki,T.; Katayama,I.; Hamzavi,I.; Lan,C. C.; Goh,B. K.; Anbar,T.; Silva de Castro,C.; Lee,A. Y.; Parsad,D.; van Geel,N.; Le Poole,I. C.; Oiso,N.; Benzekri,L.; Spritz,R.; Gauthier,Y.; Hann,S. K.; Picardo,M.; Taieb,A.; Vitiligo Global Issue Consensus Conference PanelistsRevised classification/nomenclature of vitiligo and related issues: the Vitiligo Global Issues Consensus Conference Pigment Cell & Melanoma Research 2012 ;25(3):E1-13
Mehrotra,S.; Al-Khami,A. A.; Klarquist,J.; Husain,S.; Naga,O.; Eby,J. M.; Murali,A. K.; Lyons,G. E.; Li,M.; Spivey,N. D.; Norell,H.; Martins da Palma,T.; Onicescu,G.; Diaz-Montero,C. M.; Garrett-Mayer,E.; Cole,D. J.; Le Poole,I. C.; Nishimura,M. I.A coreceptor-independent transgenic human TCR mediates anti-tumor and anti-self immunity in mice Journal of immunology (Baltimore, Md.: 1950) 2012 ;189(4):1627-1638
Elassiuty,Y. E.; Klarquist,J.; Speiser,J.; Yousef,R. M.; El Refaee,A. A.; Hunter,N. S.; Shaker,O. G.; Gundeti,M.; Nieuweboer-Krobotova,L.; Le Poole,I. C.Heme oxygenase-1 expression protects melanocytes from stress-induced cell death: implications for vitiligo. Experimental dermatology 2011 ;20(6):496-501
Keerthivasan,S.; Suleiman,R.; Lawlor,R.; Roderick,J.; Bates,T.; Minter,L.; Anguita,J.; Juncadella,I.; Nickoloff,B. J.; Le Poole,I. C.; Miele,L.; Osborne,B. A.Notch signaling regulates mouse and human Th17 differentiation. Journal of Immunology 2011 ;187(2):692-701
Hariharan,V.; Toole,T.; Klarquist,J.; Mosenson,J.; Longley,B. J.; Le Poole,I. C.Topical application of bleaching phenols; in-vivo studies and mechanism of action relevant to melanoma treatment. Melanoma research 2011 ;21(2):115-126
Hariharan,V.; Klarquist,J.; Reust,M. J.; Koshoffer,A.; McKee,M. D.; Boissy,R. E.; Le Poole,I. C.Monobenzyl ether of hydroquinone and 4-tertiary butyl phenol activate markedly different physiological responses in melanocytes: relevance to skin depigmentation. Journal of Investigative Dermatology 2010 ;130(1):211-220
Voris,J. P.; Sitailo,L. A.; Rahn,H. R.; Defnet,A.; Gerds,A. T.; Sprague,R.; Yadav,V.; Le Poole,I. C.; Denning,M. F.Functional alterations in protein kinase C beta II expression in melanoma. Pigment Cell & Melanoma Research 2010 ;23(2):216-224
Klarquist,J.; Denman,C. J.; Hernandez,C.; Wainwright,D. A.; Strickland,F. M.; Overbeck,A.; Mehrotra,S.; Nishimura,M. I.; Le Poole,I. C.Reduced skin homing by functional Treg in vitiligo Pigment Cell & Melanoma Research 2010 ;23(2):276-286
Liu,J. W.; Sun,P.; Yan,Q.; Paller,A. S.; Gerami,P.; Ho,N.; Vashi,N.; Le Poole,I. C.; Wang,X. Q.De-N-acetyl GM3 promotes melanoma cell migration and invasion through urokinase plasminogen activator receptor signaling-dependent MMP-2 activation Cancer research 2009 ;69(22):8662-8669
Moore,T. V.; Lyons,G. E.; Brasic,N.; Roszkowski,J. J.; Voelkl,S.; Mackensen,A.; Kast,W. M.; Le Poole,I. C.; Nishimura,M. I.Relationship between CD8-dependent antigen recognition, T cell functional avidity, and tumor cell recognition Cancer immunology, immunotherapy : CII 2009 ;58(5):719-728
Klarquist,J.; Barfuss,A.; Kandala,S.; Reust,M. J.; Braun,R. K.; Hu,J.; Dilling,D. F.; McKee,M. D.; Boissy,R. E.; Love,R. B.; Nishimura,M. I.; Le Poole,I. C.Melanoma-associated antigen expression in lymphangioleiomyomatosis renders tumor cells susceptible to cytotoxic T cells. American Journal of Pathology 2009 ;175(6):2463-2472
Ivanova,K.; Lambers,B.; van den Wijngaard,R.; Le Poole,I. C.; Grigorieva,O.; Gerzer,R.; Das,P. K.Immortalization of human melanocytes does not alter the de novo properties of nitric oxide to induce cell detachment from extracellular matrix components via cGMP In vitro cellular & developmental biology.Animal 2008 ;44(8-9):385-395
Schallreuter,K. U.; Bahadoran,P.; Picardo,M.; Slominski,A.; Elassiuty,Y. E.; Kemp,E. H.; Giachino,C.; Liu,J. B.; Luiten,R. M.; Lambe,T.; Le Poole,I. C.; Dammak,I.; Onay,H.; Zmijewski,M. A.; Dell'Anna,M. L.; Zeegers,M. P.; Cornall,R. J.; Paus,R.; Ortonne,J. P.; Westerhof,W.Vitiligo pathogenesis: autoimmune disease, genetic defect, excessive reactive oxygen species, calcium imbalance, or what else? Experimental dermatology 2008 ;17(2):139-40; discussion 141-60
Le Poole,I. C.; ElMasri,W. M.; Denman,C. J.; Kroll,T. M.; Bommiasamy,H.; Lyons Eiben,G.; Kast,W. M.Langerhans cells and dendritic cells are cytotoxic towards HPV16 E6 and E7 expressing target cells. Cancer Immunology, Immunotherapy 2008 ;57(6):789-797
Le Poole,I. C.; Luiten,R. M.Autoimmune etiology of generalized vitiligo Current directions in autoimmunity 2008 ;10:227-243
Denman,C. J.; McCracken,J.; Hariharan,V.; Klarquist,J.; Oyarbide-Valencia,K.; Guevara-Patino,J. A.; Le Poole,I. C.HSP70i accelerates depigmentation in a mouse model of autoimmune vitiligo. Journal of Investigative Dermatology 2008 ;128(8):2041-2048
Oyarbide-Valencia,K.; van den Boorn,J. G.; Denman,C. J.; Li,M.; Carlson,J. M.; Hernandez,C.; Nishimura,M. I.; Das,P. K.; Luiten,R. M.; Le Poole,I. C.Therapeutic implications of autoimmune vitiligo T cells Autoimmunity Reviews 2006 ;5(7):486-492
van den Boorn,J. G.; Le Poole,I. C.; Luiten,R. M.T-cell avidity and tuning: the flexible connection between tolerance and autoimmunity International reviews of immunology 2006 ;25(3-4):235-258
Kroll,T. M.; Bommiasamy,H.; Boissy,R. E.; Hernandez,C.; Nickoloff,B. J.; Mestril,R.; Le Poole,I. C.4-Tertiary butyl phenol exposure sensitizes human melanocytes to dendritic cell-mediated killing: relevance to vitiligo. Journal of Investigative Dermatology 2005 ;124(4):798-806
Cassetti,M. C.; McElhiney,S. P.; Shahabi,V.; Pullen,J. K.; Le Poole,I. C.; Eiben,G. L.; Smith,L. R.; Kast,W. M.Antitumor efficacy of Venezuelan equine encephalitis virus replicon particles encoding mutated HPV16 E6 and E7 genes Vaccine 2004 ;22(3-4):520-527
Stennett,L. S.; Riker,A. I.; Kroll,T. M.; Chamberlin,J.; Miki,T.; Nickoloff,B. J.; Le Poole,I. C.Expression of gp100 and CDK2 in melanoma cells is not co-regulated by a shared promoter region. Pigment Cell Research 2004 ;17(5):525-532
Le Poole,I. C.; Wankowicz-Kalinska,A.; van den Wijngaard,R. M.; Nickoloff,B. J.; Das,P. K.Autoimmune aspects of depigmentation in vitiligo Journal of Investigative Dermatology.Symposium Proceedings 2004 ;9(1):68-72
Le Poole,I. C.; Stennett,L. S.; Bonish,B. K.; Dee,L.; Robinson,J. K.; Hernandez,C.; Hann,S. K.; Nickoloff,B. J.Expansion of vitiligo lesions is associated with reduced epidermal CDw60 expression and increased expression of HLA-DR in perilesional skin. British Journal of Dermatology 2003 ;149(4):739-748
Fausch,S. C.; Da Silva,D. M.; Eiben,G. L.; Le Poole,I. C.; Kast,W. M.HPV protein/peptide vaccines: from animal models to clinical trials Frontiers in bioscience : a journal and virtual library 2003 ;8:s81-91
Le Poole,I. C.; Bommiasamy,H.; Bocchetta,M.; Kast,W. M.Advances in prophylactic cancer vaccine research Expert Review of Anticancer Therapy 2003 ;3(4):537-545
Le Poole,I. C.; Bommiasamy,H.; Kast,W. M.Recent progress in tumour vaccine development Expert opinion on investigational drugs 2003 ;12(6):971-981
Eiben,G. L.; da Silva,D. M.; Fausch,S. C.; Le Poole,I. C.; Nishimura,M. I.; Kast,W. M.Cervical cancer vaccines: recent advances in HPV research Viral immunology 2003 ;16(2):111-121
Le Poole,I. C.; Riker,A. I.; Quevedo,M. E.; Stennett,L. S.; Wang,E.; Marincola,F. M.; Kast,W. M.; Robinson,J. K.; Nickoloff,B. J.Interferon-gamma reduces melanosomal antigen expression and recognition of melanoma cells by cytotoxic T cells The American journal of pathology 2002 ;160(2):521-528
Le Poole,I. C.; Gerberi,M. A.; Kast,W. M.Emerging strategies in tumor vaccines Current opinion in oncology 2002 ;14(6):641-648
Le Poole,I. C.; Sarangarajan,R.; Zhao,Y.; Stennett,L. S.; Brown,T. L.; Sheth,P.; Miki,T.; Boissy,R. E.'VIT1', a novel gene associated with vitiligo Pigment Cell Research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2001 ;14(6):475-484
Das,P. K.; van den Wijngaard,R. M.; Wankowicz-Kalinska,A.; Le Poole,I. C.A symbiotic concept of autoimmunity and tumour immunity: lessons from vitiligo Trends in immunology 2001 ;22(3):130-136
Minwalla,L.; Zhao,Y.; Cornelius,J.; Babcock,G. F.; Wickett,R. R.; Le Poole,I. C.; Boissy,R. E.Inhibition of melanosome transfer from melanocytes to keratinocytes by lectins and neoglycoproteins in an in vitro model system Pigment Cell Research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society 2001 ;14(3):185-194
Minwalla,L.; Zhao,Y.; Le Poole,I. C.; Wickett,R. R.; Boissy,R. E.Keratinocytes play a role in regulating distribution patterns of recipient melanosomes in vitro The Journal of investigative dermatology 2001 ;117(2):341-347
van den Wijngaard,R. M.; Aten,J.; Scheepmaker,A.; Le Poole,I. C.; Tigges,A. J.; Westerhof,W.; Das,P. K.Expression and modulation of apoptosis regulatory molecules in human melanocytes: significance in vitiligo The British journal of dermatology 2000 ;143(3):573-581
Yang,F.; Sarangarajan,R.; Le Poole,I. C.; Medrano,E. E.; Boissy,R. E.The cytotoxicity and apoptosis induced by 4-tertiary butylphenol in human melanocytes are independent of tyrosinase activity The Journal of investigative dermatology 2000 ;114(1):157-164
Le Poole,I. C.; Boissy,R. E.; Sarangarajan,R.; Chen,J.; Forristal,J. J.; Sheth,P.; Westerhof,W.; Babcock,G.; Das,P. K.; Saelinger,C. B.PIG3V, an immortalized human vitiligo melanocyte cell line, expresses dilated endoplasmic reticulum In vitro cellular & developmental biology.Animal 2000 ;36(5):309-319
Meije,C. B.; Mooi,W. J.; Le Poole,I. C.; Van Muijen,G. N.; Das,P. K.Micro-anatomy related antigen expression in melanocytic lesions The Journal of pathology 2000 ;190(5):572-578