Profile Image
Clodia Osipo Photo
Clodia Osipo
Associate Professor
Primary Department
Microbiology and Immunology
Appointment Request
Request an Appointment
Advanced Degrees
Loyola University Chicago , Chicago , IL , United States
Family and Friends
Cell cycles
Drug Resistance
Translational Research
Sobol,A.; Askonas,C.; Alani,S.; Weber,M. J.; Ananthanarayanan,V.; Osipo,C.; Bocchetta,M.Deubiquitinase OTUD6B Isoforms Are Important Regulators of Growth and Proliferation Molecular cancer research : MCR 2017 ;15(2):117-127
Nunes,J.; Zhang,H.; Angelopoulos,N.; Chhetri,J.; Osipo,C.; Grothey,A.; Stebbing,J.; Giamas,G.ATG9A loss confers resistance to trastuzumab via c-Cbl mediated Her2 degradation Oncotarget 2016 ; :
Kim,J. L.; Ha,G. H.; Campo,L.; Denning,M. F.; Patel,T. B.; Osipo,C.; Lin,S. Y.; Breuer,E. K.The role of Rak in the regulation of stability and function of BRCA1 Oncotarget 2015 ; :
Das,S.; Sondarva,G.; Viswakarma,N.; Nair,R. S.; Osipo,C.; Tzivion,G.; Rana,B.; Rana,A.Human Epidermal Growth Factor Receptor 2 (HER2) Impedes MLK3 Kinase Activity to Support Breast Cancer Cell Survival The Journal of biological chemistry 2015 ;290(35):21705-21712
Pandya,K.; Wyatt,D.; Gallagher,B.; Shah,D.; Baker,A.; Bloodworth,J.; Zlobin,A.; Pannuti,A.; Green,A.; Ellis,I. O.; Filipovic,A.; Sagert,J.; Rana,A.; Albain,K. S.; Miele,L.; Denning,M. F.; Osipo,C.PKCalpha Attenuates Jagged-1-Mediated Notch Signaling in ErbB-2-Positive Breast Cancer to Reverse Trastuzumab Resistance Clinical cancer research : an official journal of the American Association for Cancer Research 2015 ; :
Weber,C. E.; Kothari,A. N.; Wai,P. Y.; Li,N. Y.; Driver,J.; Zapf,M. A.; Franzen,C. A.; Gupta,G. N.; Osipo,C.; Zlobin,A.; Syn,W. K.; Zhang,J.; Kuo,P. C.; Mi,Z.Osteopontin mediates an MZF1-TGF-beta1-dependent transformation of mesenchymal stem cells into cancer-associated fibroblasts in breast cancer Oncogene 2014 ;34(37):4821-4833
Baker,A. T.; Zlobin,A.; Osipo,C.Notch-EGFR/HER2 Bidirectional Crosstalk in Breast Cancer Frontiers in oncology 2014 ;4:360
Yun,J.; Pannuti,A.; Espinoza,I.; Zhu,H.; Hicks,C.; Zhu,X.; Caskey,M.; Rizzo,P.; D'Souza,G.; Backus,K.; Denning,M. F.; Coon,J.; Sun,M.; Bresnick,E. H.; Osipo,C.; Wu,J.; Strack,P. R.; Tonetti,D. A.; Miele,L.Crosstalk between PKCalpha and Notch-4 in endocrine-resistant breast cancer cells Oncogenesis 2013 ;2:e60
Pekmezci,M.; Szpaderska,A.; Osipo,C.; Ersahin,C.Evaluation of biomarkers in multifocal/multicentric invasive breast carcinomas International Journal of Surgical Pathology 2013 ;21(2):126-132
Speiser,J. J.; Ersahin,C.; Osipo,C.The functional role of notch signaling in triple-negative breast cancer Vitamins and hormones 2013 ;93:277-306
Olsauskas-Kuprys,R.; Zlobin,A.; Osipo,C.Gamma secretase inhibitors of Notch signaling OncoTargets and therapy 2013 ;6:943-955
Pekmezci,M.; Szpaderska,A.; Osipo,C.; Ersahin,C.The Effect of Cold Ischemia Time and/or Formalin Fixation on Estrogen Receptor, Progesterone Receptor, and Human Epidermal Growth Factor Receptor-2 Results in Breast Carcinoma Pathology research international 2012 ;2012:947041
Clementz,A. G.; Rogowski,A.; Pandya,K.; Miele,L.; Osipo,C.NOTCH-1 and NOTCH-4 are novel gene targets of PEA3 in breast cancer: novel therapeutic implications Breast cancer research : BCR 2011 ;13(3):R63
Pandya,K.; Meeke,K.; Clementz,A. G.; Rogowski,A.; Roberts,J.; Miele,L.; Albain,K. S.; Osipo,C.Targeting both Notch and ErbB-2 signalling pathways is required for prevention of ErbB-2-positive breast tumour recurrence. British journal of cancer 2011 ;105(6):796-806
Hao,L.; Rizzo,P.; Osipo,C.; Pannuti,A.; Wyatt,D.; Cheung,L. W.; Sonenshein,G.; Osborne,B. A.; Miele,L.Notch-1 activates estrogen receptor-alpha-dependent transcription via IKKalpha in breast cancer cells. Oncogene 2010 ;29(2):201-213
Rizzo,P.; Osipo,C.; Pannuti,A.; Golde,T.; Osborne,B.; Miele,L.Targeting Notch signaling cross-talk with estrogen receptor and ErbB-2 in breast cancer Advances in Enzyme Regulation 2009 ;49(1):134-141
Mehta,K.; Osipo,C.Trastuzumab resistance: role for Notch signaling Thescientificworldjournal 2009 ;9:1438-1448
Rizzo,P.; Miao,H.; D'Souza,G.; Osipo,C.; Song,L. L.; Yun,J.; Zhao,H.; Mascarenhas,J.; Wyatt,D.; Antico,G.; Hao,L.; Yao,K.; Rajan,P.; Hicks,C.; Siziopikou,K.; Selvaggi,S.; Bashir,A.; Bhandari,D.; Marchese,A.; Lendahl,U.; Qin,J. Z.; Tonetti,D. A.; Albain,K.; Nickoloff,B. J.; Miele,L.Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches Cancer research 2008 ;68(13):5226-5235
Rizzo,P.; Osipo,C.; Foreman,K. E.; Golde,T.; Osborne,B.; Miele,L.Rational targeting of Notch signaling in cancer Oncogene 2008 ;27(38):5124-5131
Osipo,C.; Golde,T. E.; Osborne,B. A.; Miele,L. A.Off the beaten pathway: the complex cross talk between Notch and NF-kappaB. Laboratory Investigation 2008 ;88(1):11-17
Osipo,C.; Patel,P.; Rizzo,P.; Clementz,A. G.; Hao,L.; Golde,T. E.; Miele,L.ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor. Oncogene 2008 ;27(37):5019-5032
Paunesku,T.; Vogt,S.; Lai,B.; Maser,J.; Stojicevic,N.; Thurn,K. T.; Osipo,C.; Liu,H.; Legnini,D.; Wang,Z.; Lee,C.; Woloschak,G. E.Intracellular distribution of TiO2-DNA oligonucleotide nanoconjugates directed to nucleolus and mitochondria indicates sequence specificity Nano letters 2007 ;7(3):596-601
Osipo,C.; Meeke,K.; Cheng,D.; Weichel,A.; Bertucci,A.; Liu,H.; Jordan,V. C.Role for HER2/neu and HER3 in fulvestrant-resistant breast cancer. International journal of oncology 2007 ;30(2):509-520
Osipo,C.; Miele,L.Hedgehog signaling in hepatocellular carcinoma: novel therapeutic strategy targeting hedgehog signaling in HCC Cancer Biology & Therapy 2006 ;5(2):238-239
Liu,H.; Cheng,D.; Weichel,A. K.; Osipo,C.; Wing,L. K.; Chen,B.; Louis,T. E.; Jordan,V. C.Cooperative effect of gefitinib and fumitremorgin c on cell growth and chemosensitivity in estrogen receptor alpha negative fulvestrant-resistant MCF-7 cells International journal of oncology 2006 ;29(5):1237-1246
Lewis,J. S.; Osipo,C.; Meeke,K.; Jordan,V. C.Estrogen-induced apoptosis in a breast cancer model resistant to long-term estrogen withdrawal The Journal of steroid biochemistry and molecular biology 2005 ;94(1-3):131-141
Osipo,C.; Gajdos,C.; Cheng,D.; Jordan,V. C.Reversal of tamoxifen resistant breast cancer by low dose estrogen therapy The Journal of steroid biochemistry and molecular biology 2005 ;93(2-5):249-256
Osipo,C.; Meeke,K.; Liu,H.; Cheng,D.; Lim,S.; Weichel,A.; Jordan,V. C.Trastuzumab therapy for tamoxifen-stimulated endometrial cancer Cancer research 2005 ;65(18):8504-8513
Levenson,A. S.; Thurn,K. E.; Simons,L. A.; Veliceasa,D.; Jarrett,J.; Osipo,C.; Jordan,V. C.; Volpert,O. V.; Satcher,R. L.,Jr; Gartenhaus,R. B.MCT-1 oncogene contributes to increased in vivo tumorigenicity of MCF7 cells by promotion of angiogenesis and inhibition of apoptosis Cancer research 2005 ;65(23):10651-10656
Osipo,C.; Liu,H.; Meeke,K.; Jordan,V. C.The consequences of exhaustive antiestrogen therapy in breast cancer: estrogen-induced tumor cell death Experimental biology and medicine (Maywood, N.J.) 2004 ;229(8):722-731
Osipo,C.; Gajdos,C.; Liu,H.; Chen,B.; Jordan,V. C.Paradoxical action of fulvestrant in estradiol-induced regression of tamoxifen-stimulated breast cancer Journal of the National Cancer Institute 2003 ;95(21):1597-1608
Liu,H.; Lee,E. S.; Gajdos,C.; Pearce,S. T.; Chen,B.; Osipo,C.; Loweth,J.; McKian,K.; De Los Reyes,A.; Wing,L.; Jordan,V. C.Apoptotic action of 17beta-estradiol in raloxifene-resistant MCF-7 cells in vitro and in vivo Journal of the National Cancer Institute 2003 ;95(21):1586-1597
Jordan,V. C.; Osipo,C.; Schafer,J. M.; Fox,J. E.; Cheng,D.; Liu,H.Changing role of the oestrogen receptor in the life and death of breast cancer cells Breast (Edinburgh, Scotland) 2003 ;12(6):432-441
Osipo,C.; Dorman,S.; Frankfater,A.Loss of insulin-like growth factor II receptor expression promotes growth in cancer by increasing intracellular signaling from both IGF-I and insulin receptors Experimental cell research 2001 ;264(2):388-396