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Charles Hemenway
Primary Department
Pediatric Hematology/Oncology
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Cancer in Children and Adolescents
Bleeding Disorders in Children and Adolescents
Anemia in Children and Adolescents
Loyola Center for Health at Homer Glen
Ronald McDonald ® Children's Hospital
American Board of Pediatrics Subspecialty Pediatric Hematology & Oncology
Advanced Degrees
Duke University , Durham , NC , United States
Medical School
University of Massachusetts Medical School
University of Florida, Internal Medicine & Pediatrics
Duke University Medical Center, Pediatrics: Pediatric Hematology-Oncology
Mehrhoff CJ, Hemenway CS, Suh EEmergence of a Ph-negative Clone in a Child With Ph+ ALL. JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY 2019 ; :
Kuntimaddi,A.; Achille,N. J.; Thorpe,J.; Lokken,A. A.; Singh,R.; Hemenway,C. S.; Adli,M.; Zeleznik-Le,N. J.; Bushweller,J. H.Degree of Recruitment of DOT1L to MLL-AF9 Defines Level of H3K79 Di- and Tri-methylation on Target Genes and Transformation Potential Cell reports 2015 ;11(5):808-820
Barretto,N. N.; Karahalios,D. S.; You,D.; Hemenway,C. S.An AF9/ENL-targted peptide with therapeutic potential in mixed lineage leukemias Journal of experimental therapeutics & oncology 2014 ;10(4):293-300
Lokken,A. A.; Achille,N. J.; Chang,M. J.; Lin,J. J.; Kuntimaddi,A.; Leach,B. I.; Malik,B.; Nesbit,J. B.; Zhang,S.; Bushweller,J. H.; Zeleznik-Le,N. J.; Hemenway,C. S.Importance of a specific amino acid pairing for murine MLL leukemias driven by MLLT1/3 or AFF1/4 Leukemia research 2014 ;38(11):1309-1315
Malik,B.; Hemenway,C. S.CBX8, a component of the Polycomb PRC1 complex, modulates DOT1L-mediated gene expression through AF9/MLLT3 FEBS letters 2013 ;587(18):3038-3044
Lin,J. J.; Hemenway,C. S.Hsp90 directly modulates the spatial distribution of AF9/MLLT3 and affects target gene expression. Journal of Biological Chemistry 2010 ;285(16):11966-11973
Chang,M. J.; Wu,H.; Achille,N. J.; Reisenauer,M. R.; Chou,C. W.; Zeleznik-Le,N. J.; Hemenway,C. S.; Zhang,W.Histone H3 lysine 79 methyltransferase Dot1 is required for immortalization by MLL oncogenes Cancer research 2010 ;70(24):10234-10242
Bennett,C. A.; Winters,A. C.; Barretto,N. N.; Hemenway,C. S.Molecular targeting of MLL-rearranged leukemia cell lines with the synthetic peptide PFWT synergistically enhances the cytotoxic effect of established chemotherapeutic agents. Leukemia research 2009 ;33(7):937-947
Palermo,C. M.; Bennett,C. A.; Winters,A. C.; Hemenway,C. S.The AF4-mimetic peptide, PFWT, induces necrotic cell death in MV4-11 leukemia cells. Leukemia research 2008 ;32(4):633-642
Karras,N. A.; Hemenway,C. S.Hurricane Katrina's impact on pediatric and adult patients with sickle cell disease. Journal of Health Care for the Poor & Underserved 2007 ;18(2):382-393
Zhang,W.; Xia,X.; Reisenauer,M. R.; Hemenway,C. S.; Kone,B. C.Dot1a-AF9 complex mediates histone H3 Lys-79 hypermethylation and repression of ENaCalpha in an aldosterone-sensitive manner. Journal of Biological Chemistry 2006 ;281(26):18059-18068
Reiser,J.; Zhang,X. Y.; Hemenway,C. S.; Mondal,D.; Pradhan,L.; La Russa,V. F.Potential of mesenchymal stem cells in gene therapy approaches for inherited and acquired diseases Expert Opinion on Biological Therapy 2005 ;5(12):1571-1584
Srinivasan,R. S.; Nesbit,J. B.; Marrero,L.; Erfurth,F.; LaRussa,V. F.; Hemenway,C. S.The synthetic peptide PFWT disrupts AF4-AF9 protein complexes and induces apoptosis in t(4;11) leukemia cells Leukemia 2004 ;18(8):1364-1372
Erfurth,F.; Hemenway,C. S.; de Erkenez,A. C.; Domer,P. H.MLL fusion partners AF4 and AF9 interact at subnuclear foci Leukemia 2004 ;18(1):92-102
Srinivasan,R. S.; de Erkenez,A. C.; Hemenway,C. S.The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor Oncogene 2003 ;22(22):3395-3406
Hemenway,C. S.; de Erkenez,A. C.; Gould,G. C.The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias Oncogene 2001 ;20(29):3798-3805
Hemenway,C. S.; Halligan,B. W.; Gould,G. C.; Levy,L. S.Identification and analysis of a third mouse Polycomb gene, MPc3 Gene 2000 ;242(1-2):31-40