Profile Image
Aleksey Zima Photo
Name
Aleksey Zima
Degree
Ph.D.
Rank
Associate Professor
Primary Department
Cell and Molecular Physiology
Education
Advanced Degrees
Bogomoletz Institute of Physiology , Kiev , FR , Ukraine
Fellowships
University of Florida, Electrophysiology
Hobbies
History
Sports
Keywords
Arrhythmias
Calcium Signaling
Heart
Ion Channels
Excitation-Contraction coupling
Publications
Johnson CN, Pattanayek R, Potet F, Rebbeck RT, Blackwell DJ, Nikolaienko R, Sequeira V, Le Meur R, Radwanski PB, Davis JP, Zima AV, Cornea RL, Damo SM, Györke S, George AL Jr, Knollmann BCThe CaMKII inhibitor KN93-calmodulin interaction and implications for calmodulin tuning of NaV1.5 and RyR2 function. Cell calcium 2019 ;82:102063
Nikolaienko R, Bovo E, Zima AVRedox Dependent Modifications of Ryanodine Receptor: Basic Mechanisms and Implications in Heart Diseases. Frontiers in physiology 2018 ;9:1775
Bovo,E.; Mazurek,S. R.; Zima,A. V.The role of RyR2 oxidation in the blunted frequency-dependent facilitation of Ca(2+) transient amplitude in rabbit failing myocytes Pflugers Archiv : European journal of physiology 2018 ; :
Bovo, E; Mazurek, SR; Zima, AVOxidation of ryanodine receptor following ischemia/reperfusion increases propensity of Ca waves during ß-adrenergic receptor stimulation. American journal of physiology. Heart and circulatory physiology 2018 ;
Raguimova, ON; Smolin, N; Bovo, E; Bhayani, S; Autry, JM; Zima, AV; Robia, SLRedistribution of SERCA calcium pump conformers during intracellular calcium signaling. The Journal of biological chemistry 2018 ;293(28)
Bovo,E.; Huke,S.; Blatter,L. A.; Zima,A. V.The effect of PKA-mediated phosphorylation of ryanodine receptor on SR Ca2+ leak in ventricular myocytes Journal of Molecular and Cellular Cardiology 2017 ;104:9-16
Zima,A. V.; Mazurek,S. R.Functional Impact of Ryanodine Receptor Oxidation on Intracellular Calcium Regulation in the Heart Reviews of physiology, biochemistry and pharmacology 2016 ; :
Bovo,E.; Martin,J. L.; Tyryfter,J.; de Tombe,P. P.; Zima,A. V.R-CEPIA1er as a new tool to directly measure sarcoplasmic reticulum [Ca] in ventricular myocytes American journal of physiology.Heart and circulatory physiology 2016 ;311(1):H268-75
Bovo,E.; Mazurek,S. R.; de Tombe,P. P.; Zima,A. V.Increased Energy Demand during Adrenergic Receptor Stimulation Contributes to Ca(2+) Wave Generation Biophysical journal 2015 ;109(8):1583-1591
Bovo,E.; Mazurek,S. R.; Fill,M.; Zima,A. V.Cytosolic Ca(2+) buffering determines the intra-SR Ca(2+) concentration at which cardiac Ca(2+) sparks terminate Cell calcium 2015 ;58(3):246-253
Bovo,E.; de Tombe,P. P.; Zima,A. V.The Role of Dyadic Organization in Regulation of Sarcoplasmic Reticulum Ca(2+) Handling during Rest in Rabbit Ventricular Myocytes Biophysical journal 2014 ;106(9):1902-1909
Mazurek,S. R.; Bovo,E.; Zima,A. V.Regulation of sarcoplasmic reticulum Ca(2+) release by cytosolic glutathione in rabbit ventricular myocytes Free radical biology & medicine 2014 ;68:159-167
Zima,A. V.; Bovo,E.; Mazurek,S. R.; Rochira,J. A.; Li,W.; Terentyev,D.Ca handling during excitation-contraction coupling in heart failure Pflugers Archiv : European journal of physiology 2014 ;466(6):1129-1137
Zima,A. V.; Pabbidi,M. R.; Lipsius,S. L.; Blatter,L. A.Effects of mitochondrial uncoupling on Ca(2+) signaling during excitation-contraction coupling in atrial myocytes American journal of physiology.Heart and circulatory physiology 2013 ;304(7):H983-93
Bovo,E.; Dvornikov,A. V.; Mazurek,S. R.; de Tombe,P. P.; Zima,A. V.Mechanisms of Ca(2)+ handling in zebrafish ventricular myocytes Pflugers Archiv : European journal of physiology 2013 ;465(12):1775-1784
Bovo,E.; Lipsius,S. L.; Zima,A. V.Reactive oxygen species contribute to the development of arrhythmogenic Ca2 waves during -adrenergic receptor stimulation in rabbit cardiomyocytes. Journal of Physiology 2012 ;590(Pt 14):3291-3304
Sarkey,J. P.; Chu,M.; McShane,M.; Bovo,E.; Mou,Y. A.; Zima,A. V.; de Tombe,P. P.; Kartje,G. L.; Martin,J. L.Nogo-A knockdown inhibits hypoxia/reoxygenation-induced activation of mitochondrial-dependent apoptosis in cardiomyocytes. Journal of Molecular & Cellular Cardiology 2011 ;50(6):1044-1055
Bidwell,P.; Blackwell,D. J.; Hou,Z.; Zima,A. V.; Robia,S. L.Phospholamban binds with differential affinity to calcium pump conformers. Journal of Biological Chemistry 2011 ;286(40):35044-35050
Bovo,E.; Mazurek,S. R.; Blatter,L. A.; Zima,A. V.Regulation of sarcoplasmic reticulum Ca(2)(+) leak by cytosolic Ca(2)(+) in rabbit ventricular myocytes The Journal of physiology 2011 ;589(Pt 24):6039-6050
Picht,E.; Zima,A. V.; Shannon,T. R.; Duncan,A. M.; Blatter,L. A.; Bers,D. M.Dynamic calcium movement inside cardiac sarcoplasmic reticulum during release Circulation research 2011 ;108(7):847-856
Porta,M.; Zima,A. V.; Nani,A.; Diaz-Sylvester,P. L.; Copello,J. A.; Ramos-Franco,J.; Blatter,L. A.; Fill,M.Single ryanodine receptor channel basis of caffeine's action on Ca2+ sparks Biophysical journal 2011 ;100(4):931-938
Zima,A. V.; Bovo,E.; Bers,D. M.; Blatter,L. A.Ca(2)+ spark-dependent and -independent sarcoplasmic reticulum Ca(2)+ leak in normal and failing rabbit ventricular myocytes The Journal of physiology 2010 ;588(Pt 23):4743-4757
Domeier,T. L.; Blatter,L. A.; Zima,A. V.Changes in intra-luminal calcium during spontaneous calcium waves following sensitization of ryanodine receptor channels Channels (Austin, Tex.) 2010 ;4(2):87-92
Domeier,T. L.; Blatter,L. A.; Zima,A. V.Alteration of sarcoplasmic reticulum Ca2+ release termination by ryanodine receptor sensitization and in heart failure The Journal of physiology 2009 ;587(Pt 21):5197-5209
Qin,J.; Zima,A. V.; Porta,M.; Blatter,L. A.; Fill,M.Trifluoperazine: a rynodine receptor agonist Pflugers Archiv : European journal of physiology 2009 ;458(4):643-651
Domeier,T. L.; Zima,A. V.; Maxwell,J. T.; Huke,S.; Mignery,G. A.; Blatter,L. A.IP3 receptor-dependent Ca2+ release modulates excitation-contraction coupling in rabbit ventricular myocytes American Journal of Physiology - Heart & Circulatory Physiology 2008 ;294(2):H596-604
Kockskamper,J.; Zima,A. V.; Roderick,H. L.; Pieske,B.; Blatter,L. A.; Bootman,M. D.Emerging roles of inositol 1,4,5-trisphosphate signaling in cardiac myocytes Journal of Molecular and Cellular Cardiology 2008 ;45(2):128-147
Zima,A. V.; Picht,E.; Bers,D. M.; Blatter,L. A.Partial inhibition of sarcoplasmic reticulum ca release evokes long-lasting ca release events in ventricular myocytes: role of luminal ca in termination of ca release. Biophysical journal 2008 ;94(5):1867-1879
Zima,A. V.; Picht,E.; Bers,D. M.; Blatter,L. A.Termination of cardiac Ca2+ sparks: role of intra-SR [Ca2+], release flux, and intra-SR Ca2+ diffusion Circulation research 2008 ;103(8):e105-15
Zima,A. V.; Qin,J.; Fill,M.; Blatter,L. A.Tricyclic antidepressant amitriptyline alters sarcoplasmic reticulum calcium handling in ventricular myocytes American journal of physiology.Heart and circulatory physiology 2008 ;295(5):H2008-16
Wang,Y. G.; Zima,A. V.; Ji,X.; Pabbidi,R.; Blatter,L. A.; Lipsius,S. L.Ginsenoside Re suppresses electromechanical alternans in cat and human cardiomyocytes. American Journal of Physiology - Heart & Circulatory Physiology 2008 ;295(2):H851-9
Picht,E.; Zima,A. V.; Blatter,L. A.; Bers,D. M.SparkMaster: automated calcium spark analysis with ImageJ. American Journal of Physiology - Cell Physiology 2007 ;293(3):1073-1081
Jung,C.; Zima,A. V.; Szentesi,P.; Jona,I.; Blatter,L. A.; Niggli,E.Ca2+ release from the sarcoplasmic reticulum activated by the low affinity Ca2+ chelator TPEN in ventricular myocytes Cell calcium 2007 ;41(2):187-194
Copello,J. A.; Zima,A. V.; Diaz-Sylvester,P. L.; Fill,M.; Blatter,L. A.Ca2+ entry-independent effects of L-type Ca2+ channel modulators on Ca2+ sparks in ventricular myocytes American journal of physiology.Cell physiology 2007 ;292(6):C2129-40
Aromolaran,A. S.; Zima,A. V.; Blatter,L. A.Role of glycolytically generated ATP for CaMKII-mediated regulation of intracellular Ca2+ signaling in bovine vascular endothelial cells. American Journal of Physiology - Cell Physiology 2007 ;293(1):106-118
Zima,A. V.; Bare,D. J.; Mignery,G. A.; Blatter,L. A.IP3-dependent nuclear Ca2+ signalling in the mammalian heart. Journal of Physiology 2007 ;584(Pt 2):601-611
Zima,A. V.; Kockskamper,J.; Blatter,L. A.Cytosolic energy reserves determine the effect of glycolytic sugar phosphates on sarcoplasmic reticulum Ca2+ release in cat ventricular myocytes The Journal of physiology 2006 ;577(Pt 1):281-293
Zima,A. V.; Blatter,L. A.Redox regulation of cardiac calcium channels and transporters Cardiovascular research 2006 ;71(2):310-321
Remus,T. P.; Zima,A. V.; Bossuyt,J.; Bare,D. J.; Martin,J. L.; Blatter,L. A.; Bers,D. M.; Mignery,G. A.Biosensors to measure inositol 1,4,5-trisphosphate concentration in living cells with spatiotemporal resolution. Journal of Biological Chemistry 2006 ;281(1):608-616
Sheehan,K. A.; Zima,A. V.; Blatter,L. A.Regional differences in spontaneous Ca2+ spark activity and regulation in cat atrial myocytes. Journal of Physiology 2006 ;572(Pt 3):799-809
Kockskamper,J.; Zima,A. V.; Blatter,L. A.Modulation of sarcoplasmic reticulum Ca2+ release by glycolysis in cat atrial myocytes The Journal of physiology 2005 ;564(Pt 3):697-714
Li,X.; Zima,A. V.; Sheikh,F.; Blatter,L. A.; Chen,J.Endothelin-1-induced arrhythmogenic Ca2+ signaling is abolished in atrial myocytes of inositol-1,4,5-trisphosphate(IP3)-receptor type 2-deficient mice Circulation research 2005 ;96(12):1274-1281
Cherednichenko,G.; Zima,A. V.; Feng,W.; Schaefer,S.; Blatter,L. A.; Pessah,I. N.NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates calcium-induced calcium release Circulation research 2004 ;94(4):478-486
Zima,A. V.; Blatter,L. A.Inositol-1,4,5-trisphosphate-dependent Ca(2+) signalling in cat atrial excitation-contraction coupling and arrhythmias. Journal of Physiology 2004 ;555(Pt 3):607-615
Zima,A. V.; Copello,J. A.; Blatter,L. A.Effects of cytosolic NADH/NAD(+) levels on sarcoplasmic reticulum Ca(2+) release in permeabilized rat ventricular myocytes. Journal of Physiology 2004 ;555(Pt 3):727-741
Kockskamper,J.; Ahmmed,G. U.; Zima,A. V.; Sheehan,K. A.; Glitsch,H. G.; Blatter,L. A.Palytoxin disrupts cardiac excitation-contraction coupling through interactions with P-type ion pumps. American Journal of Physiology - Cell Physiology 2004 ;287(2):527-538
Zima,A. V.; Copello,J. A.; Blatter,L. A.Differential modulation of cardiac and skeletal muscle ryanodine receptors by NADH. FEBS letters 2003 ;547(1-3):32-36
Zima,A. V.; Kockskamper,J.; Mejia-Alvarez,R.; Blatter,L. A.Pyruvate modulates cardiac sarcoplasmic reticulum Ca2+ release in rats via mitochondria-dependent and -independent mechanisms. Journal of Physiology 2003 ;550(Pt 3):765-783
Blatter,L. A.; Kockskamper,J.; Sheehan,K. A.; Zima,A. V.; Huser,J.; Lipsius,S. L.Local calcium gradients during excitation-contraction coupling and alternans in atrial myocytes The Journal of physiology 2003 ;546(Pt 1):19-31