Seth Robia
Primary Department
Cell and Molecular Physiology
Advanced Degrees
University of Wisconsin, Madison , Madison , WI , United States
Calcium Signaling
Alford, RF; Smolin, N; Young, HS; Gray, JJ; Robia, SLProtein docking and steered molecular dynamics suggest alternative phospholamban-binding sites on the SERCA calcium transporter. The Journal of biological chemistry 2020 ;295(32)
Bovo, E; Nikolaienko, R; Cleary, SR; Seflova, J; Kahn, D; Robia, SL; Zima, AVDimerization of SERCA2a Enhances Transport Rate and Improves Energetic Efficiency in Living Cells. Biophysical journal 2020 ;119(7)
Raguimova, ON; Aguayo-Ortiz, R; Robia, SL; Espinoza-Fonseca, LMDynamics-Driven Allostery Underlies Ca-Mediated Release of SERCA Inhibition by Phospholamban. Biophysical journal 2020 ;119(9)
Singh, DR; Dalton, MP; Cho, EE; Pribadi, MP; Zak, TJ; Šeflová, J; Makarewich, CA; Olson, EN; Robia, SLNewly Discovered Micropeptide Regulators of SERCA Form Oligomers but Bind to the Pump as Monomers. Journal of Molecular Biology 2019 ;431(22)
Larsen, EK; Weber, DK; Wang, S; Gopinath, T; Blackwell, DJ; Dalton, MP; Robia, SL; Gao, J; Veglia, GIntrinsically disordered HAX-1 regulates Ca cycling by interacting with lipid membranes and the phospholamban cytoplasmic region. Biochimica et biophysica acta. Biomembranes 2019 ;1862(1)
Bovo, E; Nikolaienko, R; Bhayani, S; Kahn, D; Cao, Q; Martin, JL; Kuo, IY; Robia, SL; Zima, AVNovel approach for quantification of endoplasmic reticulum Ca transport. American journal of physiology. Heart and circulatory physiology 2019 ;316(6)
Kömürlü, S; Bradley, M; Smolin, N; Imam, S; Pauszek, RF; Robia, SL; Millar, D; Nakayama, EE; Shioda, T; Campbell, EMDefects in assembly explain reduced antiviral activity of the G249D polymorphism in human TRIM5a. PLoS ONE 2019 ;14(3)
Raguimova, ON; Smolin, N; Bovo, E; Bhayani, S; Autry, JM; Zima, AV; Robia, SLRedistribution of SERCA calcium pump conformers during intracellular calcium signaling. The Journal of biological chemistry 2018 ;293(28)
Robia,S. L.; Young,H. S.Skin cells prefer a slower calcium pump The Journal of biological chemistry 2018 ;293(11):3890-3891
Makarewich, CA; Munir, AZ; Schiattarella, GG; Bezprozvannaya, S; Raguimova, ON; Cho, EE; Vidal, AH; Robia, SL; Bassel-Duby, R; Olson, ENThe DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy. eLife 2018 ;7
Zak,T. J.; Koshman,Y. E.; Samarel,A. M.; Robia,S. L.Regulation of Focal Adhesion Kinase through a Direct Interaction with an Endogenous Inhibitor Biochemistry 2017 ;56(35):4722-4731
Lamichhane,R.; Mukherjee,S.; Smolin,N.; Pauszek,R. F.,3rd; Bradley,M.; Sastri,J.; Robia,S. L.; Millar,D.; Campbell,E. M.Dynamic conformational changes in the rhesus TRIM5alpha dimer dictate the potency of HIV-1 restriction Virology 2017 ;500:161-168
Blackwell,D. J.; Zak,T. J.; Robia,S. L.Cardiac Calcium ATPase Dimerization Measured by Cross-Linking and Fluorescence Energy Transfer Biophysical journal 2016 ;111(6):1192-1202
Himes, RD; Smolin, N; Kukol, A; Bossuyt, J; Bers, DM; Robia, SLL30A Mutation of Phospholemman Mimics Effects of Cardiac Glycosides in Isolated Cardiomyocytes. Biochemistry 2016 ;55(44)
Dvornikov,A. V.; Smolin,N.; Zhang,M.; Martin,J. L.; Robia,S. L.; de Tombe,P. P.Restrictive cardiomyopathy Troponin-I R145W mutation does not perturb myofilament length dependent activation in human cardiac sarcomeres The Journal of biological chemistry 2016 ; :
Soller,K. J.; Verardi,R.; Jing,M.; Abrol,N.; Yang,J.; Walsh,N.; Vostrikov,V. V.; Robia,S. L.; Bowser,M. T.; Veglia,G.Rheostatic Regulation of the SERCA/Phospholamban Membrane Protein Complex Using Non-Coding RNA and Single-Stranded DNA oligonucleotides Scientific reports 2015 ;5:13000
Smolin,N.; Robia,S. L.A Structural Mechanism for Calcium Transporter Headpiece Closure The journal of physical chemistry.B 2015 ;119(4):1407-1415
Iram,S. H.; Gruber,S. J.; Raguimova,O. N.; Thomas,D. D.; Robia,S. L.ABC Transporter Structure Changes Detected by Intramolecular Fluorescence Energy Transfer for High-throughput Screening Molecular pharmacology 2015 ;88(1):84-94
Abrol,N.; de Tombe,P. P.; Robia,S. L.Acute Inotropic and Lusitropic Effects of Cardiomyopathic R9C Mutation of Phospholamban The Journal of biological chemistry 2015 ;290(11):7130
Iram,S. H.; Gruber,S. J.; Raguimova,O. N.; Thomas,D. D.; Robia,S. L.ATP-Binding Cassette Transporter Structure Changes Detected by Intramolecular Fluorescence Energy Transfer for High-Throughput Screening Molecular pharmacology 2015 ;88(1):84-94
Sastri,J.; Johnsen,L.; Smolin,N.; Imam,S.; Mukherjee,S.; Lukic,Z.; Brandariz-Nunez,A.; Robia,S. L.; Diaz-Griffero,F.; Wiethoff,C.; Campbell,E. M.Restriction of HIV-1 by rhesus TRIM5alpha is governed by alpha helices in the Linker2 region Journal of virology 2014 ;88(16):8911-8923
Abrol,N.; Smolin,N.; Armanious,G.; Ceholski,D. K.; Trieber,C. A.; Young,H. S.; Robia,S. L.Phospholamban C-terminal residues are critical determinants of the structure and function of the calcium ATPase regulatory complex The Journal of biological chemistry 2014 ;289(37):25855-25866
Gruber, SJ; Cornea, RL; Li, J; Peterson, KC; Schaaf, TM; Gillispie, GD; Dahl, R; Zsebo, KM; Robia, SL; Thomas, DDDiscovery of enzyme modulators via high-throughput time-resolved FRET in living cells. Journal of biomolecular screening 2014 ;19(2)
Pallikkuth,S.; Blackwell,D. J.; Hu,Z.; Hou,Z.; Zieman,D. T.; Svensson,B.; Thomas,D. D.; Robia,S. L.Phosphorylated Phospholamban Stabilizes a Compact Conformation of the Cardiac Calcium-ATPase Biophysical journal 2013 ;105(8):1812-1821
Koshman,Y. E.; Chu,M.; Engman,S. J.; Kim,T.; Iyengar,R.; Robia,S. L.; Samarel,A. M.Focal adhesion kinase-related nonkinase inhibits vascular smooth muscle cell invasion by focal adhesion targeting, tyrosine 168 phosphorylation, and competition for p130(Cas) binding. Arteriosclerosis, Thrombosis & Vascular Biology 2011 ;31(11):2432-2440
Xu,L.; Pallikkuth,S.; Hou,Z.; Mignery,G. A.; Robia,S. L.; Han,R.Dysferlin forms a dimer mediated by the C2 domains and the transmembrane domain in vitro and in living cells PLoS ONE 2011 ;6(11):e27884
Bidwell,P.; Blackwell,D. J.; Hou,Z.; Zima,A. V.; Robia,S. L.Phospholamban binds with differential affinity to calcium pump conformers. Journal of Biological Chemistry 2011 ;286(40):35044-35050
Lukic,Z.; Hausmann,S.; Sebastian,S.; Rucci,J.; Sastri,J.; Robia,S. L.; Luban,J.; Campbell,E. M.TRIM5alpha associates with proteasomal subunits in cells while in complex with HIV-1 virions Retrovirology 2011 ;8:93-4690-8-93
Song,Q.; Pallikkuth,S.; Bossuyt,J.; Bers,D. M.; Robia,S. L.Phosphomimetic mutations enhance oligomerization of phospholemman and modulate its interaction with the Na/K-ATPase. Journal of Biological Chemistry 2011 ;286(11):9120-9126
O'Connor,C.; Pertel,T.; Gray,S.; Robia,S. L.; Bakowska,J. C.; Luban,J.; Campbell,E. M.p62/sequestosome-1 associates with and sustains the expression of retroviral restriction factor TRIM5alpha. Journal of virology 2010 ;84(12):5997-6006
Koshman,Y. E.; Kim,T.; Chu,M.; Engman,S. J.; Iyengar,R.; Robia,S. L.; Samarel,A. M.FRNK inhibition of focal adhesion kinase-dependent signaling and migration in vascular smooth muscle cells. Arteriosclerosis, Thrombosis & Vascular Biology 2010 ;30(11):2226-2233
Bhandari,D.; Robia,S. L.; Marchese,A.The E3 ubiquitin ligase atrophin interacting protein 4 binds directly to the chemokine receptor CXCR4 via a novel WW domain-mediated interaction. Molecular biology of the cell 2009 ;20(5):1324-1339
Bossuyt,J.; Despa,S.; Han,F.; Hou,Z.; Robia,S. L.; Lingrel,J. B.; Bers,D. M.Isoform specificity of the Na/K-ATPase association and regulation by phospholemman. Journal of Biological Chemistry 2009 ;284(39):26749-26757
Hou,Z.; Kelly,E. M.; Robia,S. L.Phosphomimetic mutations increase phospholamban oligomerization and alter the structure of its regulatory complex. Journal of Biological Chemistry 2008 ;283(43):28996-29003
Kelly,E. M.; Hou,Z.; Bossuyt,J.; Bers,D. M.; Robia,S. L.Phospholamban oligomerization, quaternary structure, and sarco(endo)plasmic reticulum calcium ATPase binding measured by fluorescence resonance energy transfer in living cells. Journal of Biological Chemistry 2008 ;283(18):12202-12211
Robia,S. L.; Campbell,K. S.; Kelly,E. M.; Hou,Z.; Winters,D. L.; Thomas,D. D.Forster transfer recovery reveals that phospholamban exchanges slowly from pentamers but rapidly from the SERCA regulatory complex. Circulation research 2007 ;101(11):1123-1129