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Toni Pak
Primary Department
Cell and Molecular Physiology
Advanced Degrees
University of Colorado, Boulder , Boulder , CO , United States
Hormone Replacement
Shults,C. L.; Dingwall,C. B.; Kim,C. K.; Pinceti,E.; Rao,Y. S.; Pak,T. R.17beta-estradiol regulates the RNA-binding protein Nova1, which then regulates the alternative splicing of estrogen receptor beta in the aging female rat brain Neurobiology of aging 2018 ;61:13-22
Asimes, A; Kim, CK; Cuarenta, A; Auger, AP; Pak, TRBinge Drinking and Intergenerational Implications: Parental Preconception Alcohol Impacts Offspring Development in Rats. Journal of the Endocrine Society 2018 ;2(7)
Asimes,A.; Torcaso,A.; Pinceti,E.; Kim,C. K.; Zeleznik-Le,N. J.; Pak,T. R.Adolescent binge-pattern alcohol exposure alters genome-wide DNA methylation patterns in the hypothalamus of alcohol-naive male offspring Alcohol (Fayetteville, N.Y.) 2017 ;60:179-189
Torcaso,A.; Asimes,A.; Meagher,M.; Pak,T. R.Adolescent binge alcohol exposure increases risk assessment behaviors in male Wistar rats after exposure to an acute psychological stressor in adulthood Psychoneuroendocrinology 2017 ;76:154-161
Kim,C. K.; Torcaso,A.; Asimes,A.; Chung,W. C. J.; Pak,T. R.Structural and functional characteristics of estrogen receptor beta (ERbeta) splice variants: implications for the aging brain Journal of neuroendocrinology 2017 ; :
Pinceti,E.; Shults,C. L.; Rao,Y. S.; Pak,T. R.Differential Effects of E2 on MAPK Activity in the Brain and Heart of Aged Female Rats PLoS ONE 2016 ;11(8):e0160276
Rao,Y. S.; Pak,T. R.microRNAs and the adolescent brain: Filling the knowledge gap Neuroscience and biobehavioral reviews 2016 ;70:313-322
Rao,Y. S.; Shults,C. L.; Pinceti,E.; Pak,T. R.Prolonged ovarian hormone deprivation alters the effects of 17beta-estradiol on microRNA expression in the aged female rat hypothalamus Oncotarget 2015 ; :
Shults,C. L.; Pinceti,E.; Rao,Y. S.; Pak,T. R.Aging and Loss of Circulating 17beta-Estradiol Alters the Alternative Splicing of ERbeta in the Female Rat Brain Endocrinology 2015 ;156(11):4187-4199
Pinceti,E.; Shults,C. L.; Rao,Y. S.; Mott,N. N.; Pak,T. R.Phosphorylation alters Oestrogen Receptor beta-mediated transcription in neurons Journal of neuroendocrinology 2015 ; :
Mott,N. N.; Pinceti,E.; Rao,Y. S.; Przybycien-Szymanska,M. M.; Prins,S. A.; Shults,C. L.; Yang,X.; Glucksman,M. J.; Roberts,J. L.; Pak,T. R.Age-dependent Effects of 17beta-estradiol on the dynamics of estrogen receptor beta (ERbeta) protein-protein interactions in the ventral hippocampus Molecular & cellular proteomics : MCP 2014 ;13(3):760-779
Prins,S. A.; Przybycien-Szymanska,M. M.; Rao,Y. S.; Pak,T. R.Long-Term Effects of Peripubertal Binge EtOH Exposure on Hippocampal microRNA Expression in the Rat PLoS ONE 2014 ;9(1):e83166
Przybycien-Szymanska,M. M.; Rao,Y. S.; Prins,S. A.; Pak,T. R.Parental binge alcohol abuse alters f1 generation hypothalamic gene expression in the absence of direct fetal alcohol exposure PLoS ONE 2014 ;9(2):e89320
Rao,Y. S.; Mott,N. N.; Wang,Y.; Chung,W. C.; Pak,T. R.MicroRNAs in the aging female brain: a putative mechanism for age-specific estrogen effects Endocrinology 2013 ;154(8):2795-2806
Pak,T. R.; Rao,Y. S.; Prins,S. A.; Mott,N. N.An emerging role for microRNAs in sexually dimorphic neurobiological systems Pflugers Archiv : European journal of physiology 2013 ;465(5):655-667
Wattanapermpool,J.; de Tombe,P. P.; Pak,T. R.Sex differences in health and disease: brain and heart connections--a special issue Pflugers Archiv : European journal of physiology 2013 ;465(5):555-556
Mott,N. N.; Pak,T. R.Estrogen signaling and the aging brain: context-dependent considerations for postmenopausal hormone therapy ISRN endocrinology 2013 ;2013:814690
Tajuddin,N. F.; Przybycien-Szymanska,M. M.; Pak,T. R.; Neafsey,E. J.; Collins,M. A.Effect of repetitive daily ethanol intoxication on adult rat brain: significant changes in phospholipase A2 enzyme levels in association with increased PARP-1 indicate neuroinflammatory pathway activation Alcohol (Fayetteville, N.Y.) 2013 ;47(1):39-45
Przybycien-Szymanska,M. M.; Gillespie,R. A.; Pak,T. R.17beta-Estradiol is required for the sexually dimorphic effects of repeated binge-pattern alcohol exposure on the HPA axis during adolescence. PLoS ONE [Electronic Resource] 2012 ;7(2):e32263
Przybycien-Szymanska,M. M.; Mott,N. N.; Paul,C. R.; Gillespie,R. A.; Pak,T. R.Binge-pattern alcohol exposure during puberty induces long-term changes in HPA axis reactivity. PLoS ONE [Electronic Resource] 2011 ;6(4):e18350
Rao,Y. S.; Mott,N. N.; Pak,T. R.Effects of kisspeptin on parameters of the HPA axis. Endocrine 2011 ;39(3):220-228
Mott,N. N.; Chung,W. C.; Tsai,P. S.; Pak,T. R.Differential fibroblast growth factor 8 (FGF8)-mediated autoregulation of its cognate receptors, Fgfr1 and Fgfr3, in neuronal cell lines. PLoS ONE [Electronic Resource] 2010 ;5(4):e10143
Przybycien-Szymanska,M. M.; Rao,Y. S.; Pak,T. R.Binge-pattern alcohol exposure during puberty induces sexually dimorphic changes in genes regulating the HPA axis. American Journal of Physiology - Endocrinology & Metabolism 2010 ;298(2):E320-8
Pak,T. R.; Chung,W. C.; Hinds,L. R.; Handa,R. J.Arginine vasopressin regulation in pre- and postpubertal male rats by the androgen metabolite 3beta-diol. American Journal of Physiology - Endocrinology & Metabolism 2009 ;296(6):E1409-13