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Jonathan Kirk
Assistant Professor
Primary Department
Cell and Molecular Physiology
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Advanced Degrees
University of Pittsburgh, Pittsburgh , Pittsburgh , PA , United States
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Cardiovascular System
Marisa Stachowski, Ronald J. Holewinski, Eric Grote, Vidya Venkatraman, Jennifer Van Eyk, Jonathan KirkPhospho-proteomics in Dyssynchrony and Resynchronization reveal signaling networks Proteomics 2018 ; :
Hsu,S.; Kokkonen-Simon,K. M.; Kirk,J. A.; Kolb,T. M.; Damico,R. L.; Mathai,S. C.; Mukherjee,M.; Shah,A. A.; Wigley,F. M.; Margulies,K. B.; Hassoun,P. M.; Halushka,M. K.; Tedford,R. J.; Kass,D. A.Right Ventricular Myofilament Functional Differences in Humans with Systemic Sclerosis-associated versus Idiopathic Pulmonary Arterial Hypertension Circulation 2018 ; :
Ranek,M. J.; Stachowski,M. J.; Kirk,J. A.; Willis,M. S.The role of heat shock proteins and co-chaperones in heart failure Philosophical transactions of the Royal Society of London.Series B, Biological sciences 2018 ;373(1738):10.1098/rstb.2016.0530
Kirk,J. A.; Frangogiannis,N. G.Galectin-3 in the pathogenesis of heart failure: a causative mediator or simply a biomarker? American journal of physiology.Heart and circulatory physiology 2018 ; :
Kirk,J. A.; Kass,D. A.Cellular and Molecular Aspects of Dyssynchrony and Resynchronization Heart Failure Clinics 2017 ;13(1):29-41
Sonaglioni,A.; Baravelli,M.; Lombardo,M.; Sommese,C.; Anza,C.; Kirk,J. A.; Padeletti,L.Ventricular-arterial coupling in centenarians without cardiovascular diseases AGING CLINICAL AND EXPERIMENTAL RESEARCH 2017 ; :
Ngkelo,A.; Richart,A.; Kirk,J. A.; Bonnin,P.; Vilar,J.; Lemitre,M.; Marck,P.; Branchereau,M.; Le Gall,S.; Renault,N.; Guerin,C.; Ranek,M. J.; Kervadec,A.; Danelli,L.; Gautier,G.; Blank,U.; Launay,P.; Camerer,E.; Bruneval,P.; Menasche,P.; Heymes,C.; Luche,E.; Casteilla,L.; Cousin,B.; Rodewald,H. R.; Kass,D. A.; Silvestre,J. S.Mast cells regulate myofilament calcium sensitization and heart function after myocardial infarction The Journal of experimental medicine 2016 ;213(7):1353-1374
Kirk,J. A.; Cingolani,O. H.Thrombospondins in the transition from myocardial infarction to heart failure Journal of Molecular and Cellular Cardiology 2016 ;90:102-110
Kirk,J. A.; Holewinski,R. J.; Crowgey,E. L.; Van Eyk,J. E.Protein kinase G signaling in cardiac pathophysiology: Impact of proteomics on clinical trials Proteomics 2016 ;16(5):894-905
Kirk,J. A.; Kass,D. A.Cellular and Molecular Aspects of Dyssynchrony and Resynchronization Cardiac electrophysiology clinics 2015 ;7(4):585-597
Fert-Bober,J.; Giles,J. T.; Holewinski,R. J.; Kirk,J. A.; Uhrigshardt,H.; Crowgey,E. L.; Andrade,F.; Bingham,C. O.,3rd; Park,J. K.; Halushka,M. K.; Kass,D. A.; Bathon,J. M.; Van Eyk,J. E.Citrullination of myofilament proteins in heart failure Cardiovascular research 2015 ;108(2):232-242
Lee,D. I.; Zhu,G.; Sasaki,T.; Cho,G. S.; Hamdani,N.; Holewinski,R.; Jo,S. H.; Danner,T.; Zhang,M.; Rainer,P. P.; Bedja,D.; Kirk,J. A.; Ranek,M. J.; Dostmann,W. R.; Kwon,C.; Margulies,K. B.; Van Eyk,J. E.; Paulus,W. J.; Takimoto,E.; Kass,D. A.Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease Nature 2015 ;519(7544):472-476
Kirk,J. A.; Chakir,K.; Lee,K. H.; Karst,E.; Holewinski,R. J.; Pironti,G.; Tunin,R. S.; Pozios,I.; Abraham,T. P.; de Tombe,P.; Rockman,H. A.; Van Eyk,J. E.; Craig,R.; Farazi,T. G.; Kass,D. A.Pacemaker-induced transient asynchrony suppresses heart failure progression Science translational medicine 2015 ;7(319):319ra207
Kooij,V.; Venkatraman,V.; Kirk,J. A.; Ubaida-Mohien,C.; Graham,D. R.; Faber,M. J.; Van Eyk,J. E.Identification of cardiac myofilament protein isoforms using multiple mass spectrometry based approaches Proteomics.Clinical applications 2014 ;8(7-8):578-589
Kooij,V.; Venkatraman,V.; Tra,J.; Kirk,J. A.; Rowell,J.; Blice-Baum,A.; Cammarato,A.; Van Eyk,J. E.Sizing up models of heart failure: Proteomics from flies to humans Proteomics.Clinical applications 2014 ;8(9-10):653-664
Kirk,J. A.; Paolocci,N.New redox-related arrows in the arsenal of cardiac disease treatment Antioxidants & redox signaling 2014 ;21(14):1945-1948
Kirk,J. A.; Holewinski,R. J.; Kooij,V.; Agnetti,G.; Tunin,R. S.; Witayavanitkul,N.; de Tombe,P. P.; Gao,W. D.; Van Eyk,J.; Kass,D. A.Cardiac resynchronization sensitizes the sarcomere to calcium by reactivating GSK-3beta The Journal of clinical investigation 2014 ;124(1):129-138
Agnetti,G.; Halperin,V. L.; Kirk,J. A.; Chakir,K.; Guo,Y.; Lund,L.; Nicolini,F.; Gherli,T.; Guarnieri,C.; Caldarera,C. M.; Tomaselli,G. F.; Kass,D. A.; Van Eyk,J. E.Desmin modifications associate with amyloid-like oligomers deposition in heart failure Cardiovascular research 2014 ;102(1):24-34
Kirk,J. A.; Kass,D. A.Electromechanical dyssynchrony and resynchronization of the failing heart Circulation research 2013 ;113(6):765-776
Kirk,J. A.; Saccomani,M. P.; Shroff,S. G.A Priori Identifiability Analysis of Cardiovascular Models Cardiovascular engineering and technology 2013 ;4(4):500-512
Kirk,J. A.; Zhang,P.; Murphy,A. M.; Van Eyk,J. E.Troponin I alterations detected by multiple-reaction monitoring: how might this impact the study of heart failure? Expert review of proteomics 2013 ;10(1):5-8
Zhang,P.; Kirk,J. A.; Ji,W.; dos Remedios,C. G.; Kass,D. A.; Van Eyk,J. E.; Murphy,A. M.Multiple reaction monitoring to identify site-specific troponin I phosphorylated residues in the failing human heart Circulation 2012 ;126(15):1828-1837
Rainer,P. P.; Doleschal,B.; Kirk,J. A.; Sivakumaran,V.; Saad,Z.; Groschner,K.; Maechler,H.; Hoefler,G.; Bauernhofer,T.; Samonigg,H.; Hutterer,G.; Kass,D. A.; Pieske,B.; von Lewinski,D.; Pichler,M.Sunitinib causes dose-dependent negative functional effects on myocardium and cardiomyocytes BJU international 2012 ;110(10):1455-1462
Gupta,A.; Akki,A.; Wang,Y.; Leppo,M. K.; Chacko,V. P.; Foster,D. B.; Caceres,V.; Shi,S.; Kirk,J. A.; Su,J.; Lai,S.; Paolocci,N.; Steenbergen,C.; Gerstenblith,G.; Weiss,R. G.Creatine kinase-mediated improvement of function in failing mouse hearts provides causal evidence the failing heart is energy starved The Journal of clinical investigation 2012 ;122(1):291-302
Cingolani,O. H.; Kirk,J. A.; Seo,K.; Koitabashi,N.; Lee,D. I.; Ramirez-Correa,G.; Bedja,D.; Barth,A. S.; Moens,A. L.; Kass,D. A.Thrombospondin-4 is required for stretch-mediated contractility augmentation in cardiac muscle Circulation research 2011 ;109(12):1410-1414
Clause,K. C.; Tinney,J. P.; Liu,L. J.; Gharaibeh,B.; Huard,J.; Kirk,J. A.; Shroff,S. G.; Fujimoto,K. L.; Wagner,W. R.; Ralphe,J. C.; Keller,B. B.; Tobita,K.A three-dimensional gel bioreactor for assessment of cardiomyocyte induction in skeletal muscle-derived stem cells Tissue engineering.Part C, Methods 2010 ;16(3):375-385
Kirk,J. A.; MacGowan,G. A.; Evans,C.; Smith,S. H.; Warren,C. M.; Mamidi,R.; Chandra,M.; Stewart,A. F.; Solaro,R. J.; Shroff,S. G.Left ventricular and myocardial function in mice expressing constitutively pseudophosphorylated cardiac troponin I Circulation research 2009 ;105(12):1232-1239
Naghshin,J.; McGaffin,K. R.; Witham,W. G.; Mathier,M. A.; Romano,L. C.; Smith,S. H.; Janczewski,A. M.; Kirk,J. A.; Shroff,S. G.; O'Donnell,C. P.Chronic intermittent hypoxia increases left ventricular contractility in C57BL/6J mice Journal of applied physiology (Bethesda, Md.: 1985) 2009 ;107(3):787-793
MacGowan,G. A.; Kirk,J. A.; Evans,C.; Shroff,S. G.Pressure-calcium relationships in perfused mouse hearts American journal of physiology.Heart and circulatory physiology 2006 ;290(6):H2614-24