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Mashkoor A. Choudhry Photo
Name
Mashkoor A. Choudhry
Degree
Ph.D.
Rank
Professor
Primary Department
Surgical Research
Joint Department
Microbiology and Immunology
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Education
Advanced Degrees
Aligarh Muslim University , Aligarh , FR , India
Summaries
Research Interest: Gut immunity and epithelial barrier in response to injury

Intestine is the major reservoir of bacteria within the body and it maintains an effective barrier against these bacteria under healthy conditions. However, this barrier is compromised following alcohol exposure, burn injury and other traumatic insults; a compromised intestinal barrier facilitates the entry of intestinal bacteria and their products to extra intestinal sites. These intestinal-derived bacteria or their products present a major clinical problem to burn/trauma victims as well as in patients with history of alcohol exposure and are implicated in the subsequent development of multiple organ failure. Dr. Choudhry’s laboratory is interested in learning the mechanisms of impaired gut barrier following alcohol exposure and major trauma such as burn.

The focus of his ongoing research is on: 1) T cell mediated immunity against gut-derived bacteria; 2) Neutrophils and their role in tissue damage and defense against bacteria; 3) Epithelial cells and their role in defense against gut bacteria.

Additionally, emerging evidence indicates that gut microflora plays critical roles in maintaining an effective gut barrier. So, another major aspect of ongoing studies in Dr. Choudhry’s laboratory is to determine whether alcohol exposure or traumatic injury influences the gut microflora and whether changes in gut microflora have any relationship with impaired gut mucosal immunity and epithelial barrier function under those conditions.

View a partial list of Dr. Choudhry's publications through the National Library of Medicine's PubMed online database.
Keywords
Alcohol/Alcoholism
Burns
Gastrointestinal Diseases
Immunopathology
Inflammation
Inflammatory Bowel Disease
Inflammatory Bowel Disease
Publications
van Langeveld,I.; Gagnon,R. C.; Conrad,P. F.; Gamelli,R. L.; Martin,B.; Choudhry,M. A.; Mosier,M. J.Multiple-Drug Resistance in Burn Patients: A Retrospective Study on the Impact of Antibiotic Resistance on Survival and Length of Stay Journal of burn care & research : official publication of the American Burn Association 2017 ;38(2):99-105
Hammer,A. M.; Morris,N. L.; Cannon,A. R.; Khan,O. M.; Gagnon,R. C.; Movtchan,N. V.; van Langeveld,I.; Li,X.; Gao,B.; Choudhry,M. A.Interleukin-22 Prevents Microbial Dysbiosis and Promotes Intestinal Barrier Regeneration Following Acute Injury Shock (Augusta, Ga.) 2017 ; :
Morris,N. L.; Hammer,A. M.; Cannon,A. R.; Gagnon,R. C.; Li,X.; Choudhry,M. A.Dysregulation of microRNA biogenesis in the small intestine after ethanol and burn injury Biochimica et biophysica acta 2017 ; :
Cannon,A. R.; Akhtar,S.; Hammer,A. M.; Morris,N. L.; Javorski,M. J.; Li,X.; Kennedy,R. H.; Gamelli,R. L.; Choudhry,M. A.Effects of Mesalamine Treatment on Gut Barrier Integrity After Burn Injury Journal of burn care & research : official publication of the American Burn Association 2016 ; :
Cannon,A. R.; Morris,N. L.; Hammer,A. M.; Curtis,B.; Remick,D. G.; Yeligar,S. M.; Poole,L.; Burnham,E. L.; Wyatt,T. A.; Molina,P. E.; So-Armah,K.; Cisneros,T.; Wang,G.; Lang,C. H.; Mandrekar,P.; Kovacs,E. J.; Choudhry,M. A.Alcohol and inflammatory responses: Highlights of the 2015 Alcohol and Immunology Research Interest Group (AIRIG) meeting Alcohol (Fayetteville, N.Y.) 2016 ;54:73-77
Yu,H. P.; Chaudry,I. H.; Choudhry,M. A.; Hsing,C. H.; Liu,F. C.; Xia,Z.Inflammatory Response to Traumatic Injury: Clinical and Animal Researches in Inflammation Mediators of inflammation 2015 ;2015:729637
Li,X.; Hammer,A. M.; Rendon,J. L.; Choudhry,M. A.Intestine Immune Homeostasis after Alcohol and Burn Injury Shock (Augusta, Ga.) 2015 ;43(6):540-548
Hammer,A. M.; Khan,O. M.; Morris,N. L.; Li,X.; Movtchan,N. V.; Cannon,A. R.; Choudhry,M. A.The Effects of Alcohol Intoxication and Burn Injury on the Expression of Claudins and Mucins in the Small and Large Intestines Shock (Augusta, Ga.) 2015 ; :
Earley,Z. M.; Akhtar,S.; Green,S. J.; Naqib,A.; Khan,O.; Cannon,A. R.; Hammer,A. M.; Morris,N. L.; Li,X.; Eberhardt,J. M.; Gamelli,R. L.; Kennedy,R. H.; Choudhry,M. A.Burn Injury Alters the Intestinal Microbiome and Increases Gut Permeability and Bacterial Translocation PLoS ONE 2015 ;10(7):e0129996
Chen,M. M.; O'Halloran,E. B.; Ippolito,J. A.; Choudhry,M. A.; Kovacs,E. J.Alcohol potentiates postburn remote organ damage through shifts in fluid compartments mediated by bradykinin Shock (Augusta, Ga.) 2015 ;43(1):80-84
Morris,N. L.; Ippolito,J. A.; Curtis,B. J.; Chen,M. M.; Friedman,S. L.; Hines,I. N.; Haddad,G. E.; Chang,S. L.; Brown,L. A.; Waldschmidt,T. J.; Mandrekar,P.; Kovacs,E. J.; Choudhry,M. A.Alcohol and inflammatory responses: Summary of the 2013 Alcohol and Immunology Research Interest Group (AIRIG) meeting Alcohol (Fayetteville, N.Y.) 2015 ;49(1):1-6
Morris,N. L.; Li,X.; Earley,Z. M.; Choudhry,M. A.Regional variation in expression of pro-inflammatory mediators in the intestine following a combined insult of alcohol and burn injury Alcohol (Fayetteville, N.Y.) 2015 ;49(507):511
Hammer,A. M.; Morris,N. L.; Cannon,A. R.; Shults,J. A.; Curtis,B.; Casey,C. A.; Sueblinvong,V.; Persidsky,Y.; Nixon,K.; Brown,L. A.; Waldschmidt,T.; Mandrekar,P.; Kovacs,E. J.; Choudhry,M. A.Summary of the 2014 Alcohol and Immunology Research Interest Group (AIRIG) meeting Alcohol (Fayetteville, N.Y.) 2015 ;49(8):767-772
Hammer,A. M.; Morris,N. L.; Earley,Z. M.; Choudhry,M. A.The First Line of Defense: The Effects of Alcohol on Post-Burn Intestinal Barrier, Immune Cells, and Microbiome Alcohol research : current reviews 2015 ;37(2):209-222
Rendon,J. L.; Li,X.; Brubaker,A. L.; Kovacs,E. J.; Gamelli,R. L.; Choudhry,M. A.The role of aryl hydrocarbon receptor in interleukin-23-dependent restoration of interleukin-22 following ethanol exposure and burn injury Annals of Surgery 2014 ;259(3):582-590
Li,X.; Rendon,J. L.; Choudhry,M. A.T Cell IFN-gamma Suppression Following Alcohol and Burn Injury Is Independent of miRNA155 PLoS ONE 2014 ;9(8):e105314
Chen,M. M.; Zahs,A.; Brown,M. M.; Ramirez,L.; Turner,J. R.; Choudhry,M. A.; Kovacs,E. J.An alteration of the gut-liver axis drives pulmonary inflammation after intoxication and burn injury in mice American journal of physiology.Gastrointestinal and liver physiology 2014 ;307(7):G711-8
Ippolito,J. A.; Curtis,B. J.; Choudhry,M. A.; Kovacs,E. J.Alcohol and immunology: Summary of the 2012 Alcohol and Immunology Research Interest Group (AIRIG) meeting Alcohol (Fayetteville, N.Y.) 2013 ;47(8):589-593
Brubaker,A. L.; Rendon,J. L.; Ramirez,L.; Choudhry,M. A.; Kovacs,E. J.Reduced neutrophil chemotaxis and infiltration contributes to delayed resolution of cutaneous wound infection with advanced age Journal of immunology (Baltimore, Md.: 1950) 2013 ;190(4):1746-1757
Zahs,A.; Bird,M. D.; Ramirez,L.; Choudhry,M. A.; Kovacs,E. J.Anti-IL-6 antibody treatment but not IL-6 knockout improves intestinal barrier function and reduces inflammation after binge ethanol exposure and burn injury Shock 2013 ;39(4):373-379
Sigman,M.; Conrad,P.; Rendon,J. L.; Akhtar,S.; Eberhardt,J.; Gamelli,R. L.; Choudhry,M. A.Noninvasive measurement of intestinal inflammation after burn injury Journal of burn care & research : official publication of the American Burn Association 2013 ;34(6):633-638
Chen,M. M.; Palmer,J. L.; Ippolito,J. A.; Curtis,B. J.; Choudhry,M. A.; Kovacs,E. J.Intoxication by intraperitoneal injection or oral gavage equally potentiates postburn organ damage and inflammation Mediators of inflammation 2013 ;2013:971481
Rendon,J. L.; Li,X.; Akhtar,S.; Choudhry,M. A.Interleukin-22 modulates gut epithelial and immune barrier functions following acute alcohol exposure and burn injury Shock (Augusta, Ga.) 2013 ;39(1):11-18
Zahs,A.; Bird,M. D.; Ramirez,L.; Turner,J. R.; Choudhry,M. A.; Kovacs,E. J.Inhibition of long myosin light-chain kinase activation alleviates intestinal damage after binge ethanol exposure and burn injury. American Journal of Physiology - Gastrointestinal & Liver Physiology 2012 ;303(6):G705-12
Zahs,A.; Cook,R. T.; Waldschimdt,T. J.; Choudhry,M. A.; Kovacs,E. J.; Bird,M. D.Alcohol and inflammation and infection: clinical and experimental systems--summary of the 2010 Alcohol and Immunology Research Interest Group Meeting. Alcohol 2012 ;46(2):147-153
Zahs,A.; Curtis,B. J.; Waldschmidt,T. J.; Brown,L. A.; Gauthier,T. W.; Choudhry,M. A.; Kovacs,E. J.; Bird,M. D.Alcohol and epigenetic changes: summary of the 2011 Alcohol and Immunology Research Interest Group (AIRIG) meeting Alcohol (Fayetteville, N.Y.) 2012 ;46(8):783-787
Biju,P. G.; Garg,S.; Wang,W.; Choudhry,M. A.; Kovacs,E. J.; Fink,L. M.; Hauer-Jensen,M.Procalcitonin as a predictive biomarker for total body irradiation-induced bacterial load and lethality in mice Shock (Augusta, Ga.) 2012 ;38(2):170-176
Rendon,J. L.; Choudhry,M. A.Th17 cells: critical mediators of host responses to burn injury and sepsis Journal of leukocyte biology 2012 ;92(3):529-538
Li,X.; Akhtar,S.; Choudhry,M. A.Alteration in intestine tight junction protein phosphorylation and apoptosis is associated with increase in IL-18 levels following alcohol intoxication and burn injury. Biochimica et biophysica acta 2012 ;1822(2):196-203
Li,X.; Rendon,J. L.; Akhtar,S.; Choudhry,M. A.Activation of toll-like receptor 2 prevents suppression of T-cell interferon gamma production by modulating p38/extracellular signal-regulated kinase pathways following alcohol and burn injury Molecular medicine (Cambridge, Mass.) 2012 ;18:982-991
Li,X.; Akhtar,S.; Kovacs,E. J.; Gamelli,R. L.; Choudhry,M. A.Inflammatory response in multiple organs in a mouse model of acute alcohol intoxication and burn injury. Journal of Burn Care & Research 2011 ;32(4):489-497
Akhtar,S.; Li,X.; Kovacs,E. J.; Gamelli,R. L.; Choudhry,M. A.Interleukin-18 delays neutrophil apoptosis following alcohol intoxication and burn injury. Molecular Medicine 2011 ;17(1-2):88-94
Suzuki,T.; Kawasaki,T.; Choudhry,M. A.; Chaudry,I. H.Role of PPARgamma in the salutary effects of 17beta-estradiol on Kupffer cell cytokine production following trauma-hemorrhage Journal of cellular physiology 2011 ;226(1):205-211
Kawasaki,T.; Suzuki,T.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.Salutary effects of 17beta-estradiol on Peyer's patch T cell functions following trauma-hemorrhage Cytokine 2010 ;51(2):166-172
Bird,M. D.; Zahs,A.; Deburghgraeve,C.; Ramirez,L.; Choudhry,M. A.; Kovacs,E. J.Decreased pulmonary inflammation following ethanol and burn injury in mice deficient in TLR4 but not TLR2 signaling. Alcoholism: Clinical & Experimental Research 2010 ;34(10):1733-1741
Hsu,J. T.; Kan,W. H.; Hsieh,C. H.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.Mechanism of salutary effects of estrogen on cardiac function following trauma-hemorrhage: Akt-dependent HO-1 up-regulation Critical care medicine 2009 ;37(8):2338-2344
Hsieh,C. H.; Nickel,E. A.; Chen,J.; Schwacha,M. G.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.Mechanism of the salutary effects of estrogen on kupffer cell phagocytic capacity following trauma-hemorrhage: pivotal role of Akt activation Journal of immunology (Baltimore, Md.: 1950) 2009 ;182(7):4406-4414
Hsu,J. T.; Kan,W. H.; Hsieh,C. H.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.Role of extracellular signal-regulated protein kinase (ERK) in 17beta-estradiol-mediated attenuation of lung injury after trauma-hemorrhage Surgery 2009 ;145(2):226-234
Akhtar,S.; Li,X.; Chaudry,I. H.; Choudhry,M. A.Neutrophil chemokines and their role in IL-18-mediated increase in neutrophil O2- production and intestinal edema following alcohol intoxication and burn injury. American Journal of Physiology - Gastrointestinal & Liver Physiology 2009 ;297(2):G340-7
Kawasaki,T.; Choudhry,M. A.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.Effect of interleukin-15 on depressed splenic dendritic cell functions following trauma-hemorrhage American journal of physiology.Cell physiology 2009 ;296(1):C124-30
Bird,M. D.; Choudhry,M. A.; Molina,P. E.; Kovacs,E. J.Alcohol and trauma: a summary of the Satellite Symposium at the 30th Annual Meeting of the Shock Society. Alcohol 2009 ;43(3):247-252
Li,X.; Chaudry,I. H.; Choudhry,M. A.ERK and not p38 pathway is required for IL-12 restoration of T cell IL-2 and IFN-gamma in a rodent model of alcohol intoxication and burn injury. Journal of Immunology 2009 ;183(6):3955-3962
Yang,S.; Hu,S.; Chen,J.; Choudhry,M. A.; Rue,L. W.,3rd; Bland,K. I.; Chaudry,I. H.Mechanism of hepatoprotection in proestrus female rats following trauma-hemorrhage: heme oxygenase-1-derived normalization of hepatic inflammatory responses Journal of leukocyte biology 2009 ;85(6):1015-1026
Kan,W. H.; Hsieh,C. H.; Schwacha,M. G.; Choudhry,M. A.; Raju,R.; Bland,K. I.; Chaudry,I. H.Flutamide protects against trauma-hemorrhage-induced liver injury via attenuation of the inflammatory response, oxidative stress, and apopotosis Journal of applied physiology (Bethesda, Md.: 1985) 2008 ;105(2):595-602
Kan,W. H.; Hsu,J. T.; Ba,Z. F.; Schwacha,M. G.; Chen,J.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.p38 MAPK-dependent eNOS upregulation is critical for 17beta-estradiol-mediated cardioprotection following trauma-hemorrhage American journal of physiology.Heart and circulatory physiology 2008 ;294(6):H2627-36
Kan,W. H.; Hsu,J. T.; Schwacha,M. G.; Choudhry,M. A.; Raju,R.; Bland,K. I.; Chaudry,I. H.Selective inhibition of iNOS attenuates trauma-hemorrhage/resuscitation-induced hepatic injury Journal of applied physiology (Bethesda, Md.: 1985) 2008 ;105(4):1076-1082
Kan,W. H.; Hsu,J. T.; Schwacha,M. G.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.Estrogen ameliorates trauma-hemorrhage-induced lung injury via endothelial nitric oxide synthase-dependent activation of protein kinase G Annals of Surgery 2008 ;248(2):294-302
Lederer,J. A.; Brownstein,B. H.; Lopez,M. C.; Macmillan,S.; Delisle,A. J.; Macconmara,M. P.; Choudhry,M. A.; Xiao,W.; Lekousi,S.; Cobb,J. P.; Baker,H. V.; Mannick,J. A.; Chaudry,I. H.; Inflammation and the Host Response to Injury Collaborative Research Program ParticipantsComparison of longitudinal leukocyte gene expression after burn injury or trauma-hemorrhage in mice Physiological Genomics 2008 ;32(3):299-310
Li,X.; Schwacha,M. G.; Chaudry,I. H.; Choudhry,M. A.Inhibition of protein tyrosine phosphatases prevents mesenteric lymph node T-cell suppression following alcohol intoxication and burn injury Journal of burn care & research : official publication of the American Burn Association 2008 ;29(3):519-530
Choudhry,M. A.; Chaudry,I. H.17beta-Estradiol: a novel hormone for improving immune and cardiovascular responses following trauma-hemorrhage Journal of leukocyte biology 2008 ;83(3):518-522
Li,X.; Schwacha,M. G.; Chaudry,I. H.; Choudhry,M. A.Acute alcohol intoxication potentiates neutrophil-mediated intestinal tissue damage after burn injury Shock (Augusta, Ga.) 2008 ;29(3):377-383
Li,X.; Schwacha,M. G.; Chaudry,I. H.; Choudhry,M. A.Heme oxygenase-1 protects against neutrophil-mediated intestinal damage by down-regulation of neutrophil p47phox and p67phox activity and O2- production in a two-hit model of alcohol intoxication and burn injury Journal of immunology (Baltimore, Md.: 1950) 2008 ;180(10):6933-6940
Kawasaki,T.; Choudhry,M. A.; Schwacha,M. G.; Fujimi,S.; Lederer,J. A.; Bland,K. I.; Chaudry,I. H.Trauma-hemorrhage inhibits splenic dendritic cell proinflammatory cytokine production via a mitogen-activated protein kinase process American journal of physiology.Cell physiology 2008 ;294(3):C754-64
Kawasaki,T.; Choudhry,M. A.; Suzuki,T.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.17beta-Estradiol's salutary effects on splenic dendritic cell functions following trauma-hemorrhage are mediated via estrogen receptor-alpha Molecular immunology 2008 ;45(2):376-385
Shimizu,T.; Suzuki,T.; Yu,H. P.; Yokoyama,Y.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.The role of estrogen receptor subtypes on hepatic neutrophil accumulation following trauma-hemorrhage: direct modulation of CINC-1 production by Kupffer cells Cytokine 2008 ;43(1):88-92
Hsieh,C. H.; Frink,M.; Hsieh,Y. C.; Kan,W. H.; Hsu,J. T.; Schwacha,M. G.; Choudhry,M. A.; Chaudry,I. H.The role of MIP-1 alpha in the development of systemic inflammatory response and organ injury following trauma hemorrhage Journal of immunology (Baltimore, Md.: 1950) 2008 ;181(4):2806-2812
Suzuki,T.; Yu,H. P.; Hsieh,Y. C.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.Estrogen-mediated activation of non-genomic pathway improves macrophages cytokine production following trauma-hemorrhage Journal of cellular physiology 2008 ;214(3):662-672
Suzuki,T.; Yu,H. P.; Hsieh,Y. C.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.Mitogen activated protein kinase (MAPK) mediates non-genomic pathway of estrogen on T cell cytokine production following trauma-hemorrhage Cytokine 2008 ;42(1):32-38
Moeinpour,F.; Choudhry,M. A.; de Figueiredo,L. F.; Bland,K. I.; Chaudry,I. H.Estradiol's salutary effects on keratinocytes following trauma-hemorrhage are mediated by estrogen receptor (ER)-alpha and ER-beta Molecular medicine (Cambridge, Mass.) 2008 ;14(11-12):689-696
Hsu,J. T.; Kan,W. H.; Hsieh,Y. C.; Choudhry,M. A.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.Mechanism of estrogen-mediated improvement in cardiac function after trauma-hemorrhage: p38-dependent normalization of cardiac Akt phosphorylation and glycogen levels Shock (Augusta, Ga.) 2008 ;30(4):372-378
Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.Trauma and immune response--effect of gender differences Injury 2007 ;38(12):1382-1391
Moeinpour,F.; Choudhry,M. A.; Kawasaki,T.; Timares,L.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.17 Beta-estradiol normalizes Toll receptor 4, mitogen activated protein kinases and inflammatory response in epidermal keratinocytes following trauma-hemorrhage Molecular immunology 2007 ;44(13):3317-3323
Yu,H. P.; Hsieh,Y. C.; Suzuki,T.; Choudhry,M. A.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.The PI3K/Akt pathway mediates the nongenomic cardioprotective effects of estrogen following trauma-hemorrhage Annals of Surgery 2007 ;245(6):971-977
Daniel,T.; Thobe,B. M.; Chaudry,I. H.; Choudhry,M. A.; Hubbard,W. J.; Schwacha,M. G.Regulation of the postburn wound inflammatory response by gammadelta T-cells Shock (Augusta, Ga.) 2007 ;28(3):278-283
Matsutani,T.; Kang,S. C.; Miyashita,M.; Sasajima,K.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.Liver cytokine production and ICAM-1 expression following bone fracture, tissue trauma, and hemorrhage in middle-aged mice American journal of physiology.Gastrointestinal and liver physiology 2007 ;292(1):G268-74
Matsutani,T.; Kang,S. C.; Miyashita,M.; Sasajima,K.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.Young and middle-age associated differences in cytokeratin expression after bone fracture, tissue trauma, and hemorrhage American Journal of Surgery 2007 ;193(1):61-68
Thobe,B. M.; Frink,M.; Hildebrand,F.; Schwacha,M. G.; Hubbard,W. J.; Choudhry,M. A.; Chaudry,I. H.The role of MAPK in Kupffer cell toll-like receptor (TLR) 2-, TLR4-, and TLR9-mediated signaling following trauma-hemorrhage Journal of cellular physiology 2007 ;210(3):667-675
Hsieh,Y. C.; Frink,M.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.Metabolic modulators following trauma sepsis: sex hormones Critical care medicine 2007 ;35(9 Suppl):S621-9
Hsieh,Y. C.; Frink,M.; Hsieh,C. H.; Choudhry,M. A.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.Downregulation of migration inhibitory factor is critical for estrogen-mediated attenuation of lung tissue damage following trauma-hemorrhage American journal of physiology.Lung cellular and molecular physiology 2007 ;292(5):L1227-32
Hsieh,Y. C.; Frink,M.; Kawasaki,T.; Thobe,B. M.; Choudhry,M. A.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.Downregulation of TLR4-dependent ATP production is critical for estrogen-mediated immunoprotection in Kupffer cells following trauma-hemorrhage Journal of cellular physiology 2007 ;211(2):364-370
Hsieh,Y. C.; Frink,M.; Thobe,B. M.; Hsu,J. T.; Choudhry,M. A.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.17Beta-estradiol downregulates Kupffer cell TLR4-dependent p38 MAPK pathway and normalizes inflammatory cytokine production following trauma-hemorrhage Molecular immunology 2007 ;44(9):2165-2172
Hsieh,Y. C.; Yu,H. P.; Frink,M.; Suzuki,T.; Choudhry,M. A.; Schwacha,M. G.; Chaudry,I. H.G protein-coupled receptor 30-dependent protein kinase A pathway is critical in nongenomic effects of estrogen in attenuating liver injury after trauma-hemorrhage The American journal of pathology 2007 ;170(4):1210-1218
Hsu,J. T.; Hsieh,Y. C.; Kan,W. H.; Chen,J. G.; Choudhry,M. A.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.Role of p38 mitogen-activated protein kinase pathway in estrogen-mediated cardioprotection following trauma-hemorrhage American journal of physiology.Heart and circulatory physiology 2007 ;292(6):H2982-7
Hsu,J. T.; Kan,W. H.; Hsieh,C. H.; Choudhry,M. A.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.Mechanism of estrogen-mediated attenuation of hepatic injury following trauma-hemorrhage: Akt-dependent HO-1 up-regulation Journal of leukocyte biology 2007 ;82(4):1019-1026
Shimizu,T.; Yu,H. P.; Hsieh,Y. C.; Choudhry,M. A.; Suzuki,T.; Bland,K. I.; Chaudry,I. H.Flutamide attenuates pro-inflammatory cytokine production and hepatic injury following trauma-hemorrhage via estrogen receptor-related pathway Annals of Surgery 2007 ;245(2):297-304
Shimizu,T.; Yu,H. P.; Suzuki,T.; Szalay,L.; Hsieh,Y. C.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.The role of estrogen receptor subtypes in ameliorating hepatic injury following trauma-hemorrhage Journal of Hepatology 2007 ;46(6):1047-1054
Frink,M.; Hsieh,Y. C.; Hsieh,C. H.; Pape,H. C.; Choudhry,M. A.; Schwacha,M. G.; Chaudry,I. H.Keratinocyte-derived chemokine plays a critical role in the induction of systemic inflammation and tissue damage after trauma-hemorrhage Shock (Augusta, Ga.) 2007 ;28(5):576-581
Frink,M.; Hsieh,Y. C.; Hu,S.; Hsieh,C. H.; Pape,H. C.; Choudhry,M. A.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.Mechanism of salutary effects of finasteride on post-traumatic immune/inflammatory response: upregulation of estradiol synthesis Annals of Surgery 2007 ;246(5):836-843
Frink,M.; Hsieh,Y. C.; Thobe,B. M.; Choudhry,M. A.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.TLR4 regulates Kupffer cell chemokine production, systemic inflammation and lung neutrophil infiltration following trauma-hemorrhage Molecular immunology 2007 ;44(10):2625-2630
Frink,M.; Lu,A.; Thobe,B. M.; Hsieh,Y. C.; Choudhry,M. A.; Schwacha,M. G.; Kunkel,S. L.; Chaudry,I. H.Monocyte chemoattractant protein-1 influences trauma-hemorrhage-induced distal organ damage via regulation of keratinocyte-derived chemokine production American Journal of Physiology.Regulatory, Integrative and Comparative Physiology 2007 ;292(3):R1110-6
Frink,M.; Thobe,B. M.; Hsieh,Y. C.; Choudhry,M. A.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.17beta-Estradiol inhibits keratinocyte-derived chemokine production following trauma-hemorrhage American journal of physiology.Lung cellular and molecular physiology 2007 ;292(2):L585-91
Li,X.; Kovacs,E. J.; Schwacha,M. G.; Chaudry,I. H.; Choudhry,M. A.Acute alcohol intoxication increases interleukin-18-mediated neutrophil infiltration and lung inflammation following burn injury in rats. American Journal of Physiology - Lung Cellular & Molecular Physiology 2007 ;292(5):1193-1201
Suzuki,T.; Shimizu,T.; Yu,H. P.; Hsieh,Y. C.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.Estrogen receptor-alpha predominantly mediates the salutary effects of 17beta-estradiol on splenic macrophages following trauma-hemorrhage American journal of physiology.Cell physiology 2007 ;293(3):C978-84
Suzuki,T.; Shimizu,T.; Yu,H. P.; Hsieh,Y. C.; Choudhry,M. A.; Chaudry,I. H.Salutary effects of 17beta-estradiol on T-cell signaling and cytokine production after trauma-hemorrhage are mediated primarily via estrogen receptor-alpha American journal of physiology.Cell physiology 2007 ;292(6):C2103-11
Suzuki,T.; Shimizu,T.; Yu,H. P.; Hsieh,Y. C.; Choudhry,M. A.; Schwacha,M. G.; Chaudry,I. H.Tissue compartment-specific role of estrogen receptor subtypes in immune cell cytokine production following trauma-hemorrhage Journal of applied physiology (Bethesda, Md.: 1985) 2007 ;102(1):163-168
Yang,S.; Hu,S.; Choudhry,M. A.; Rue,L. W.,3rd; Bland,K. I.; Chaudry,I. H.Anti-rat soluble IL-6 receptor antibody down-regulates cardiac IL-6 and improves cardiac function following trauma-hemorrhage Journal of Molecular and Cellular Cardiology 2007 ;42(3):620-630
Lu,A.; Frink,M.; Choudhry,M. A.; Schwacha,M. G.; Hubbard,W. J.; Rue,L. W.,3rd; Bland,K. I.; Chaudry,I. H.Mitochondria play an important role in 17beta-estradiol attenuation of H(2)O(2)-induced rat endothelial cell apoptosis American journal of physiology.Endocrinology and metabolism 2007 ;292(2):E585-93
Yu,H. P.; Hsieh,Y. C.; Suzuki,T.; Choudhry,M. A.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.Mechanism of the nongenomic effects of estrogen on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of the PI-3K/Akt pathway Journal of leukocyte biology 2007 ;82(3):774-780
Hildebrand,F.; Hubbard,W. J.; Choudhry,M. A.; Thobe,B. M.; Pape,H. C.; Chaudry,I. H.Are the protective effects of 17beta-estradiol on splenic macrophages and splenocytes after trauma-hemorrhage mediated via estrogen-receptor (ER)-alpha or ER-beta? Journal of leukocyte biology 2006 ;79(6):1173-1180
Hildebrand,F.; Hubbard,W. J.; Choudhry,M. A.; Thobe,B. M.; Pape,H. C.; Chaudry,I. H.Effects of 17beta-estradiol and flutamide on inflammatory response and distant organ damage following trauma-hemorrhage in metestrus females Journal of leukocyte biology 2006 ;80(4):759-765
Hildebrand,F.; Thobe,B. M.; Hubbard,W. J.; Choudhry,M. A.; Pape,H. C.; Chaudry,I. H.Effects of 17beta-estradiol and flutamide on splenic macrophages and splenocytes after trauma-hemorrhage Cytokine 2006 ;36(3-4):107-114
Hsieh,Y. C.; Choudhry,M. A.; Yu,H. P.; Shimizu,T.; Yang,S.; Suzuki,T.; Chen,J.; Bland,K. I.; Chaudry,I. H.Inhibition of cardiac PGC-1alpha expression abolishes ERbeta agonist-mediated cardioprotection following trauma-hemorrhage FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 ;20(8):1109-1117
Zheng,R.; Pan,G.; Thobe,B. M.; Choudhry,M. A.; Matsutani,T.; Samy,T. S.; Kang,S. C.; Bland,K. I.; Chaudry,I. H.MyD88 and Src are differentially regulated in Kupffer cells of males and proestrus females following hypoxia Molecular medicine (Cambridge, Mass.) 2006 ;12(4-6):65-73
Yang,S.; Choudhry,M. A.; Hsieh,Y. C.; Hu,S.; Rue,L. W.,3rd; Bland,K. I.; Chaudry,I. H.Estrus cycle: influence on cardiac function following trauma-hemorrhage American journal of physiology.Heart and circulatory physiology 2006 ;291(6):H2807-15
Yang,S.; Hu,S.; Hsieh,Y. C.; Choudhry,M. A.; Rue,L. W.,3rd; Bland,K. I.; Chaudry,I. H.Mechanism of IL-6-mediated cardiac dysfunction following trauma-hemorrhage Journal of Molecular and Cellular Cardiology 2006 ;40(4):570-579
Yu,H. P.; Choudhry,M. A.; Shimizu,T.; Hsieh,Y. C.; Schwacha,M. G.; Yang,S.; Chaudry,I. H.Mechanism of the salutary effects of flutamide on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of estrogen receptor-{beta}-dependent HO-1 Journal of leukocyte biology 2006 ;79(2):277-284
Yu,H. P.; Hsieh,Y. C.; Suzuki,T.; Shimizu,T.; Choudhry,M. A.; Schwacha,M. G.; Chaudry,I. H.Salutary effects of estrogen receptor-beta agonist on lung injury after trauma-hemorrhage American journal of physiology.Lung cellular and molecular physiology 2006 ;290(5):L1004-9
Yu,H. P.; Shimizu,T.; Choudhry,M. A.; Hsieh,Y. C.; Suzuki,T.; Bland,K. I.; Chaudry,I. H.Mechanism of cardioprotection following trauma-hemorrhagic shock by a selective estrogen receptor-beta agonist: up-regulation of cardiac heat shock factor-1 and heat shock proteins Journal of Molecular and Cellular Cardiology 2006 ;40(1):185-194
Yu,H. P.; Shimizu,T.; Hsieh,Y. C.; Suzuki,T.; Choudhry,M. A.; Schwacha,M. G.; Chaudry,I. H.Tissue-specific expression of estrogen receptors and their role in the regulation of neutrophil infiltration in various organs following trauma-hemorrhage Journal of leukocyte biology 2006 ;79(5):963-970
Yu,H. P.; Yang,S.; Hsieh,Y. C.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.Maintenance of lung myeloperoxidase activity in proestrus females after trauma-hemorrhage: upregulation of heme oxygenase-1 American journal of physiology.Lung cellular and molecular physiology 2006 ;291(3):L400-6
Daniel,T.; Alexander,M.; Hubbard,W. J.; Chaudry,I. H.; Choudhry,M. A.; Schwacha,M. G.Nitric oxide contributes to the development of a post-injury Th2 T-cell phenotype and immune dysfunction Journal of cellular physiology 2006 ;208(2):418-427
Kawasaki,T.; Choudhry,M. A.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.Lidocaine depresses splenocyte immune functions following trauma-hemorrhage in mice American journal of physiology.Cell physiology 2006 ;291(5):C1049-55
Kawasaki,T.; Fujimi,S.; Lederer,J. A.; Hubbard,W. J.; Choudhry,M. A.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.Trauma-hemorrhage induces depressed splenic dendritic cell functions in mice Journal of immunology (Baltimore, Md.: 1950) 2006 ;177(7):4514-4520
Li,X.; Rana,S. N.; Schwacha,M. G.; Chaudry,I. H.; Choudhry,M. A.A novel role for IL-18 in corticosterone-mediated intestinal damage in a two-hit rodent model of alcohol intoxication and injury Journal of leukocyte biology 2006 ;80(2):367-375
Li,X.; Schwacha,M. G.; Chaudry,I. H.; Choudhry,M. A.A role of PP1/PP2A in mesenteric lymph node T cell suppression in a two-hit rodent model of alcohol intoxication and injury Journal of leukocyte biology 2006 ;79(3):453-462
Shimizu,T.; Szalay,L.; Hsieh,Y. C.; Suzuki,T.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.A role of PPAR-gamma in androstenediol-mediated salutary effects on cardiac function following trauma-hemorrhage Annals of Surgery 2006 ;244(1):131-138
Choudhry,M. A.; Ball,A.; McEwan,I. J.The role of the general transcription factor IIF in androgen receptor-dependent transcription Molecular endocrinology (Baltimore, Md.) 2006 ;20(9):2052-2061
Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.Gender and susceptibility to sepsis following trauma Endocrine, metabolic & immune disorders drug targets 2006 ;6(2):127-135
Choudhry,M. A.; Chaudry,I. H.Alcohol intoxication and post-burn complications Frontiers in bioscience : a journal and virtual library 2006 ;11:998-1005
Choudhry,M. A.; Li,X.; Chaudry,I. H.A role for corticosterone in impaired intestinal immunity and barrier function in a rodent model of acute alcohol intoxication and burn injury Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2006 ;1(4):428-434
Hsieh,Y. C.; Yu,H. P.; Suzuki,T.; Choudhry,M. A.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.Upregulation of mitochondrial respiratory complex IV by estrogen receptor-beta is critical for inhibiting mitochondrial apoptotic signaling and restoring cardiac functions following trauma-hemorrhage Journal of Molecular and Cellular Cardiology 2006 ;41(3):511-521
Alexander,M.; Daniel,T.; Chaudry,I. H.; Choudhry,M. A.; Schwacha,M. G.T cells of the gammadelta T-cell receptor lineage play an important role in the postburn wound healing process Journal of burn care & research : official publication of the American Burn Association 2006 ;27(1):18-25
Suzuki,T.; Shimizu,T.; Szalay,L.; Choudhry,M. A.; Rue,L. W.,3rd; Bland,K. I.; Chaudry,I. H.Androstenediol ameliorates alterations in immune cells cytokine production capacity in a two-hit model of trauma-hemorrhage and sepsis Cytokine 2006 ;34(1-2):76-84
Suzuki,T.; Shimizu,T.; Yu,H. P.; Hsieh,Y. C.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.17 beta-estradiol administration following trauma-hemorrhage prevents the increase in Kupffer cell cytokine production and MAPK activation predominately via estrogen receptor-alpha Surgery 2006 ;140(2):141-148
Szalay,L.; Shimizu,T.; Suzuki,T.; Hsieh,Y. C.; Choudhry,M. A.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.Androstenediol administration after trauma-hemorrhage attenuates inflammatory response, reduces organ damage, and improves survival following sepsis American journal of physiology.Gastrointestinal and liver physiology 2006 ;291(2):G260-6
Szalay,L.; Shimizu,T.; Suzuki,T.; Yu,H. P.; Choudhry,M. A.; Schwacha,M. G.; Rue,L. W.,3rd; Bland,K. I.; Chaudry,I. H.Estradiol improves cardiac and hepatic function after trauma-hemorrhage: role of enhanced heat shock protein expression American Journal of Physiology.Regulatory, Integrative and Comparative Physiology 2006 ;290(3):R812-8
Thobe,B. M.; Frink,M.; Choudhry,M. A.; Schwacha,M. G.; Bland,K. I.; Chaudry,I. H.Src family kinases regulate p38 MAPK-mediated IL-6 production in Kupffer cells following hypoxia American journal of physiology.Cell physiology 2006 ;291(3):C476-82
Li,X.; Rana,S. N.; Kovacs,E. J.; Gamelli,R. L.; Chaudry,I. H.; Choudhry,M. A.Corticosterone suppresses mesenteric lymph node T cells by inhibiting p38/ERK pathway and promotes bacterial translocation after alcohol and burn injury. American Journal of Physiology - Regulatory Integrative & Comparative Physiology 2005 ;289(1):R37-44
Yu,H. P.; Yang,S.; Choudhry,M. A.; Hsieh,Y. C.; Bland,K. I.; Chaudry,I. H.Mechanism responsible for the salutary effects of flutamide on cardiac performance after trauma-hemorrhagic shock: Upregulation of cardiomyocyte estrogen receptors Surgery 2005 ;138(1):85-92
Fazal,N.; Choudhry,M. A.; Sayeed,M. M.Inhibition of T cell MAPKs (Erk 1/2, p38) with thermal injury is related to down-regulation of Ca2+ signaling. Biochimica et biophysica acta 2005 ;1741(1-2):113-119
Rana,S. N.; Li,X.; Chaudry,I. H.; Bland,K. I.; Choudhry,M. A.Inhibition of IL-18 reduces myeloperoxidase activity and prevents edema in intestine following alcohol and burn injury Journal of leukocyte biology 2005 ;77(5):719-728
Choudhry,M. A.; Schwacha,M. G.; Hubbard,W. J.; Kerby,J. D.; Rue,L. W.; Bland,K. I.; Chaudry,I. H.Gender differences in acute response to trauma-hemorrhage Shock (Augusta, Ga.) 2005 ;24 Suppl 1:101-106
Kavanaugh,M. J.; Clark,C.; Goto,M.; Kovacs,E. J.; Gamelli,R. L.; Sayeed,M. M.; Choudhry,M. A.Effect of acute alcohol ingestion prior to burn injury on intestinal bacterial growth and barrier function. Burns 2005 ;31(3):290-296
Choudhry,M. A.; Ba,Z. F.; Rana,S. N.; Bland,K. I.; Chaudry,I. H.Alcohol ingestion before burn injury decreases splanchnic blood flow and oxygen delivery American journal of physiology.Heart and circulatory physiology 2005 ;288(2):H716-21
Shimizu,T.; Szalay,L.; Choudhry,M. A.; Schwacha,M. G.; Rue,L. W.,3rd; Bland,K. I.; Chaudry,I. H.Mechanism of salutary effects of androstenediol on hepatic function after trauma-hemorrhage: role of endothelial and inducible nitric oxide synthase American journal of physiology.Gastrointestinal and liver physiology 2005 ;288(2):G244-50
Shimizu,T.; Szalay,L.; Hsieh,Y. C.; Choudhry,M. A.; Bland,K. I.; Chaudry,I. H.Salutary effects of androstenediol on hepatic function after trauma-hemorrhage are mediated via peroxisome proliferators-activated receptor gamma Surgery 2005 ;138(2):204-211
Choudhry,M. A.; Rana,S. N.; Kavanaugh,M. J.; Kovacs,E. J.; Gamelli,R. L.; Sayeed,M. M.Impaired intestinal immunity and barrier function: a cause for enhanced bacterial translocation in alcohol intoxication and burn injury Alcohol 2004 ;33(3):199-208
Choudhry,M. A.; Ren,X.; Romero,A.; Kovacs,E. J.; Gamelli,R. L.; Sayeed,M. M.Combined alcohol and burn injury differentially regulate P-38 and ERK activation in mesenteric lymph node T cell. Journal of Surgical Research 2004 ;121(1):62-68
Goral,J.; Choudhry,M. A.; Kovacs,E. J.Acute ethanol exposure inhibits macrophage IL-6 production: role of p38 and ERK1/2 MAPK. Journal of leukocyte biology 2004 ;75(3):553-559
Shimizu,T.; Choudhry,M. A.; Szalay,L.; Rue,L. W.,3rd; Bland,K. I.; Chaudry,I. H.Salutary effects of androstenediol on cardiac function and splanchnic perfusion after trauma-hemorrhage American Journal of Physiology.Regulatory, Integrative and Comparative Physiology 2004 ;287(2):R386-90
Kang,S. C.; Matsutani,T.; Choudhry,M. A.; Schwacha,M. G.; Rue,L. W.; Bland,K. I.; Chaudry,I. H.Are the immune responses different in middle-aged and young mice following bone fracture, tissue trauma and hemorrhage? Cytokine 2004 ;26(5):223-230
Dallal,O.; Ravindranath,T. M.; Choudhry,M. A.; Kohn,A.; Muraskas,J. K.; Namak,S. Y.; Alattar,M. H.; Sayeed,M. M.T-cell proliferative responses following sepsis in neonatal rats Biology of the neonate 2003 ;83(3):201-207
Faunce,D. E.; Gamelli,R. L.; Choudhry,M. A.; Kovacs,E. J.A role for CD1d-restricted NKT cells in injury-associated T cell suppression. Journal of leukocyte biology 2003 ;73(6):747-755
Kotadia,B. K.; Ravindranath,T. M.; Choudhry,M. A.; Haque,F.; Al-Ghoul,W.; Sayeed,M. M.Effects of pentoxyfylline on mesenteric lymph node T-cells in a rat model of thermal injury. Shock 2003 ;20(6):517-520
Plackett,T. P.; Schilling,E. M.; Faunce,D. E.; Choudhry,M. A.; Witte,P. L.; Kovacs,E. J.Aging enhances lymphocyte cytokine defects after injury. FASEB Journal 2003 ;17(6):688-689
Choudhry,M. A.; Plackett,T. P.; Schilling,E. M.; Faunce,D. E.; Gamelli,R. L.; Kovacs,E. J.Advanced age negatively influences mesenteric lymph node T cell responses after burn injury. Immunology letters 2003 ;86(2):177-182
Choudhry,M. A.; Haque,F.; Khan,M.; Fazal,N.; Al-Ghoul,W.; Ravindranath,T.; Gamelli,R. L.; Sayeed,M. M.Enteral nutritional supplementation prevents mesenteric lymph node T-cell suppression in burn injury. Critical care medicine 2003 ;31(6):1764-1770
Choudhry,M. A.; Fazal,N.; Goto,M.; Gamelli,R. L.; Sayeed,M. M.Gut-associated lymphoid T cell suppression enhances bacterial translocation in alcohol and burn injury. American Journal of Physiology - Gastrointestinal & Liver Physiology 2002 ;282(6):G937-47
Alattar,M. H.; Ravindranath,T. M.; Choudhry,M. A.; Muraskas,J. K.; Namak,S. Y.; Dallal,O.; Sayeed,M. M.Sepsis-induced alteration in T-cell Ca(2+) signaling in neonatal rats Biology of the neonate 2001 ;80(4):300-304
Ravindranath,T.; Al-Ghoul,W.; Namak,S.; Fazal,N.; Durazo-Arvizu,R. A.; Choudhry,M. A.; Sayeed,M. M.Effects of burn with and without Escherichia coli infection in rats on intestinal vs. splenic T-cell responses Critical care medicine 2001 ;29(12):2245-2250
Sir,O.; Fazal,N.; Choudhry,M. A.; Gamelli,R. L.; Sayeed,M. M.Neutrophil depletion prevents intestinal mucosal permeability alterations in burn-injured rats. American Journal of Physiology - Regulatory Integrative & Comparative Physiology 2000 ;278(5):R1224-31
Sir,O.; Fazal,N.; Choudhry,M. A.; Goris,R. J.; Gamelli,R. L.; Sayeed,M. M.Role of neutrophils in burn-induced microvascular injury in the intestine. Shock 2000 ;14(2):113-117
Choudhry,M. A.; Messingham,K. A.; Namak,S.; Colantoni,A.; Fontanilla,C. V.; Duffner,L. A.; Sayeed,M. M.; Kovacs,E. J.Ethanol exacerbates T cell dysfunction after thermal injury. Alcohol 2000 ;21(3):239-243