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A. Creation of a large research cohort, including new-born infants and adults
PI: R. Cooper et al.
Team Investigator by site:
Specific Aim:
- Enroll and follow for 10 years 2,500 infants from birth, and 2,500 persons over the age of 14...Click for more
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B. Genetic modifiers of clinical outcomes
PI: N. Hanchard, A. Wonkam, G. Lettre
Team Investigator by site:
Aims:
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C. Hemolysis and the pathophysiology of vascular complications
PI: S. Ofori-Acquah
Team Investigator by site:
Aims:
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Determine the spectrum of clinical outcomes and organ dysfunction associated with hemolysis in a longitudinal cohort of SCD patients.
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Determine the activation of hemolysis and oxidative stress protective pathways in neonates and children with SCD and the deterioration of this protection with disease progression and aging longitudinally
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Determine the genetic factors that attenuate and exacerbate hemolysis, and modulate the response to hemolysis, in SCD patients using a whole genome approach, and test for their association with clinical outcomes and organ dysfunction.
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Determine the expression of putative hemolysis-modifying genes and transcripts...Click for more
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D. Safety and efficacy of hydroxyurea (HU)
PI: B. Tayo, V. Gordeuk
Team Investigator by site:
Specific Aims:
- While a large-scale trial of HU in Africa is clearly a major priority, it is not clear that the necessary resources are available in clinical sites at this time
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E. Influence of diet / obesity
PI: S. Saraf
Team Investigator by site:
Specific Aims: To be determined...Click for more
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F. Psycholocial factors and HRQL of SCD patients
PI: A. Wonkam
Team Investigator by site:
Specific Aims: To be determined... Click for more
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