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Mashkoor A. Choudhry Photo
Mashkoor A. Choudhry
Primary Department
Research Interest: Gut immunity and epithelial barrier in response to injury <p>Intestine is the major reservoir of bacteria within the body and it maintains an effective barrier against these bacteria under healthy conditions. However, this barrier is compromised following alcohol exposure, burn injury and other traumatic insults; a compromised intestinal barrier facilitates the entry of intestinal bacteria and their products to extra intestinal sites. These intestinal-derived bacteria or their products present a major clinical problem to burn/trauma victims as well as in patients with history of alcohol exposure and are implicated in the subsequent development of multiple organ failure. Dr. Choudhry’s laboratory is interested in learning the mechanisms of impaired gut barrier following alcohol exposure and major trauma such as burn.</p> The focus of his ongoing research is on: 1) T cell mediated immunity against gut-derived bacteria; 2) Neutrophils and their role in tissue damage and defense against bacteria; 3) Epithelial cells and their role in defense against gut bacteria. <p>Additionally, emerging evidence indicates that gut microflora plays critical roles in maintaining an effective gut barrier. So, another major aspect of ongoing studies in Dr. Choudhry’s laboratory is to determine whether alcohol exposure or traumatic injury influences the gut microflora and whether changes in gut microflora have any relationship with impaired gut mucosal immunity and epithelial barrier function under those conditions. </p> View a partial list of <a href= target=_blank><strong>Dr. Choudhry's publications</strong></a> through the National Library of Medicine's PubMed online database.
Malnassy, G; Keating, CR; Gad, S; Bridgeman, B; Perera, A; Hou, W; Cotler, SJ; Ding, X; Choudhry, M; Sun, Z; Koleske, AJ; Qiu, W Inhibition of Abelson Tyrosine-Protein Kinase 2 Suppresses the Development of Alcohol-Associated Liver Disease by Decreasing PPARgamma Expression. Cellular and molecular gastroenterology and hepatology ;
McMahan, RH; Anton, P; Coleman, LG; Cresci, GAM; Crews, FT; Crotty, KM; Luck, ME; Molina, PE; Vachharajani, V; Weinberg, J; Yeligar, SM; Choudhry, MA; McCullough, RL; Kovacs, EJ Alcohol and Immunology: Mechanisms of Multi-Organ Damage. Summary of the 2022 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol (Fayetteville, N.Y.) ;
Luck, ME; Li, X; Herrnreiter, CJ; Cannon, AR; Choudhry, MA IL-27 Promotes Intestinal Barrier Integrity following Ethanol Intoxication and Burn Injury. ImmunoHorizons ; 6 8
Crotty, K; Anton, P; Coleman, LG; Morris, NL; Lewis, SA; Samuelson, DR; McMahan, RH; Hartmann, P; Kim, A; Ratna, A; Mandrekar, P; Wyatt, TA; Choudhry, MA; Kovacs, EJ; McCullough, R; Yeligar, SM A critical review of recent knowledge of alcohol's effects on the immunological response in different tissues. Alcoholism, Clinical and Experimental Research ;
Cannon, AR; Shim, EH; Kuprys, PV; Choudhry, MA IL-22 and Lactobacillus delbrueckii mitigate alcohol-induced exacerbation of DSS-induced colitis. Journal of leukocyte biology ;
Khair, S; Brenner, LA; Koval, M; Samuelson, D; Cucinello-Regland, JA; Anton, P; Piano, MR; Simon, L; Crotty, K; Sharieh, F; Travers, JB; Singh, V; Cannon, A; Kim, A; McCullough, RL; Wyatt, TA; McMahan, RH; Choudhry, MA; Kovacs, EJ New insights into the mechanism of alcohol-mediated organ damage via its impact on immunity, metabolism, and repair pathways: A Summary of the 2021 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol (Fayetteville, N.Y.) ;
Li, X; Luck, ME; Herrnreiter, CJ; Cannon, AR; Choudhry, MA IL-23 Promotes Neutrophil Extracellular Trap Formation and Bacterial Clearance in a Mouse Model of Alcohol and Burn Injury. ImmunoHorizons ; 6 1
Herrnreiter, CJ; Li, X; Luck, ME; Zilliox, MJ; Choudhry, MA Integrated analysis of dysregulated microRNA and mRNA expression in intestinal epithelial cells following ethanol intoxication and burn injury. Scientific reports ; 11 1
Talley, S; Valiauga, R; Anderson, L; Cannon, AR; Choudhry, MA; Campbell, EM DSS-induced inflammation in the colon drives a proinflammatory signature in the brain that is ameliorated by prophylactic treatment with the S100A9 inhibitor paquinimod. Journal of neuroinflammation ; 18 1
Baghdan, D; Dugas, LR; Choo-Kang, C; Plange-Rhule, J; Bovet, P; Viswanathan, B; Forrester, T; Lambert, EV; Riesen, W; Korte, W; Choudhry, MA; Luke, A The associations between alcohol intake and cardiometabolic risk in African-origin adults spanning the epidemiologic transition. BMC Public Health ; 21 1
Luck, ME; Li, X; Herrnreiter, CJ; Choudhry, MA Ethanol Intoxication and Burn Injury Increases Intestinal Regulatory T Cell Population and Regulatory T Cell Suppressive Capability. Shock (Augusta, Ga.) ;
Luck, ME; Herrnreiter, CJ; Choudhry, MA Gut Microbial Changes and their Contribution to Post-Burn Pathology. Shock (Augusta, Ga.) ;
Morris, NL; Choudhry, MA Maintenance of gut barrier integrity after injury: Trust your gut microRNAs. Journal of leukocyte biology ;
Eguia, E; Classen, T; Choudhry, M; Singer, M; Eberhardt, J ACCESS TO HEALTHCARE INSURANCE INCREASES THE RATES OF SURGERY FOR DIVERTICULITIS. International journal of healthcare management ; 14 4
Kuprys, PV; Cannon, AR; Shieh, J; Iftekhar, N; Park, SK; Eberhardt, JM; Ding, X; Choudhry, MA Alcohol decreases intestinal ratio of to and induces hepatic immune tolerance in a murine model of DSS-colitis. Gut microbes ; 12 1
Morris, NL; Cannon, AR; Li, X; Choudhry, MA Protective effects of PX478 on gut barrier in a mouse model of ethanol and burn injury. Journal of leukocyte biology ;
Wheatley, EG; Curtis, BJ; Hulsebus, HJ; Boe, DM; Najarro, K; Ir, D; Robertson, CE; Choudhry, MA; Frank, DN; Kovacs, EJ Advanced Age Impairs Intestinal Antimicrobial Peptide Response and Worsens Fecal Microbiome Dysbiosis Following Burn Injury in Mice. Shock (Augusta, Ga.) ; 53 1
Moffatt, LT; Madrzykowski, D; Gibson, ALF; Powell, HM; Cancio, LC; Wade, CE; Choudhry, MA; Kovacs, EJ; Finnerty, CC; Majetschak, M; Shupp, JW Standards in Biologic Lesions: Cutaneous Thermal Injury and Inhalation Injury Working Group 2018 Meeting Proceedings. Journal of burn care & research : official publication of the American Burn Association ; 41 3
Jeschke, MG; van Baar, ME; Choudhry, MA; Chung, KK; Gibran, NS; Logsetty, S Burn injury. Nature reviews. Disease primers ; 6 1
McMahan, RH; Afshar, M; Amedee, AM; Bishehsari, F; Carr, RM; Coleman, LG; Herrnreiter, CJ; Lewis, SL; Mandrekar, P; McCullough, RL; Morris, NL; Vasiliou, V; Wang, HJ; Yeligar, SM; Choudhry, MA; Kovacs, EJ Summary of the 2019 alcohol and immunology research interest group (AIRIG) meeting: Alcohol-mediated mechanisms of multiple organ injury. Alcohol (Fayetteville, N.Y.) ; 87
Li, X; Luck, ME; Hammer, AM; Cannon, AR; Choudhry, MA 6-Formylindolo (3, 2-b) Carbazole (FICZ)-mediated protection of gut barrier is dependent on T cells in a mouse model of alcohol combined with burn injury. Biochimica et biophysica acta. Molecular basis of disease ; 1866 11
Dyamenahalli, K; Garg, G; Shupp, JW; Kuprys, PV; Choudhry, MA; Kovacs, EJ Inhalation Injury: Unmet Clinical Needs and Future Research. Journal of burn care & research : official publication of the American Burn Association ; 40 5
Talley, S; Kalinina, O; Winek, M; Paik, W; Cannon, AR; Alonzo, F; Choudhry, MA; Knight, KL; Campbell, EM A Caspase-1 Biosensor to Monitor the Progression of Inflammation In Vivo. Journal of immunology (Baltimore, Md. : 1950) ; 203 9
Kuprys, PV; Tsukamoto, H; Gao, B; Jia, L; McGowan, J; Coopersmith, CM; Moreno, MC; Hulsebus, H; Meena, AS; Souza-Smith, FM; Roper, P; Foster, MT; Raju, SV; Marshall, SA; Fujita, M; Curtis, BJ; Wyatt, TA; Mandrekar, P; Kovacs, EJ; Choudhry, MA Summary of the 2018 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol (Fayetteville, N.Y.) ; 77
Hulsebus, HJ; Curtis, BJ; Molina, PE; Afshar, M; Boule, LA; Morris, N; Keshavarzian, A; Kolls, JK; Yeligar, SM; Price, ME; Wyatt, TA; Choudhry, MA; Kovacs, EJ Summary of the 2017 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol (Fayetteville, N.Y.) ; 69
Cannon, AR; Kuprys, PV; Cobb, AN; Ding, X; Kothari, AN; Kuo, PC; Eberhardt, JM; Hammer, AM; Morris, NL; Li, X; Choudhry, MA Alcohol enhances symptoms and propensity for infection in inflammatory bowel disease patients and a murine model of DSS-induced colitis. Journal of leukocyte biology ;
Choudhry, MA Obituary: Dr. Thomas Ray Jerrells. Journal of leukocyte biology ;
Hammer, Adam M; Morris, Niya L; Cannon, Abigail R; Shults, Jill A; Curtis, Brenda; Casey, Carol A; Sueblinvong, Viranuj; Persidsky, Yuri; Nixon, Kimberly; Brown, Lou Ann; Waldschmidt, Thomas; Mandrekar, Pranoti; Kovacs, Elizabeth J; Choudhry, Mashkoor A Summary of the 2014 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol ; 49 8