• Research Associate Professor
  • Ophthalmology

Health Sciences Library Discover Research Network


Medical School:

M.D. - University of Heidelberg, Heidelberg, Germany


Residency - The People's Hospital, Beijing University, Beijing, China

Additional Training:

Postdoctoral fellow - Loyola University Chicago, Stritch School of Medicine, Maywood, IL

Research Focus: Cornea and Ocular Surface Disease, Retina

Summary of Research Interests

Dr. Bu’s research is focused on the neuroprotection of natural substances in retinal degenerative diseases such as retinal ischemia and AMD. Dr. Bu’s group have investigated the protective effects of resveratrol and sulforaphane on the retinal ischemia-reperfusion injury, paeoniflorin and kaempferol on retinal light injury (AMD) in animal models. Using the electroretinographic, retinal morphometric and immunohistochemistry methods, the goal is to develop the novel treatments to manage retinal degenerative diseases like glaucoma, diabetic retinopathy, hypertension retinopathy and AMD. In addition, Dr. Bu also studies therapeutic effect of probiotic bacteria or bacterial metabolite(s) in dry eye disease and its underlying mechanism. The goal is to develop potential microbial therapeutics for dry eye disease.



  • Noguchi JL, Seu MY, Qiao JB, Tan IR, Swaminathan SR, McDonnell JF, Tan Z, Bu P. Kaempferol Protects Against Retinal Photoreceptor Degeneration in a Mouse Model of Light-Induced Retinal Injury. J Ocul Pharmacol Ther. 2023 Jan-Feb;39(1):80-85. doi: 10.1089/jop.2022.0128. Epub 2022 Dec 14. PMID: 36520599.


  • Gange WS, Qiao JB, Park PJ, McDonnell JF, Tan Z, Perlman JI, Bu P. Protection of Retinal Function by Nucleoside Reverse Transcriptase Inhibitors Following Retinal Ischemia/Reperfusion Injury. Journal of Ocular Pharmacology and Therapeutics. 2021 October; 37(8):485-491. doi: 10.1089/jop.2020.0083. PMID: 34448620.


  • Liu H, Gambino Jr F, Algenio CS, Wu C, Gao YC, Bouchard CS, Qiao L, Bu P, Zhao SZ. Inflammation and Oxidative Stress Induced by Lipid Peroxidation Metabolite 4-Hydroxynonenal in Human Corneal Epithelial Cells. Graefe's Archive for Clinical and Experimental Ophthalmology. 2020 May; 258: 1717-1725. doi: 10.1007/s00417-020-04647-2. PMID: 32445015.


  • Gao Y, Li CH, Bu P, Zhang LJ, Bouchard CS. Infectious Interface Keratitis (IIK) Following Lamellar Keratoplasty: A Literature Review. The Ocular Surface. 2019 October; 17(4): 635-643. doi: 10.1016/j.jtos.2019.08.001. PMID: 31415815.


  • Liu H, Gambino Jr F, Algenio CS, Bouchard CS, Qiao L, Bu P, Zhao SZ. Zidovudine Protects Hyperosmolarity-Stressed Human Corneal Epithelial Cells via Antioxidant Pathway. Biochemical and Biophysical Research Communications. 2018 May; 499(2): 177-181. doi: 10.1016/j.bbrc.2018.03.112. PMID: 29555477.
  • Till SD, Iqbal O, Dharan A, Campbell E, Bu P, Mudaliar K, Speiser J, Bouchard CS. The Roles of IL-33 and TGF-Β1 in the Pathogenesis of Stevens-Johnson Syndrome/ Toxic Epidermal Necrolysis: Potential Biomarkers for Disease Severity. Journal of Ophthalmology Eye Care. 2018 September; 1(1): 105.


  • Kang K, Tarchick MJ, Yu XS, Beight C, Bu P, Yu MZ.  Carnosic acid slows photoreceptor degeneration in the Pde6brd10 mouse model of retinitis pigmentosa. Scientific Reports. 2016 March; 6:22632. doi: 10.1038/srep22632. PMCID: PMC4785376.


  • Yu MZ, Kang K, Bu P, Bell BA, Kaul C, Qiao JB, Sturgill-Short G, Yu XS, Tarchick MJ, Beight C, Zhang SX, Peachey NS. Deficiency of CC Chemokine Ligand 2 and Decay-accelerating Factor Causes Retinal Degeneration in Mice. Experimental Eye Research. 2015 September; 138: 126-133. doi: 10.1016/j.exer.2015.05.016. PMCID: PMC5509212.
  • Ambrecht LA, Perlman JI, McDonnell JF, Zhai YG, Qiao L, Bu P. Protection of Retinal Function by Sulforaphane Following Retinal Ischemic Injury. Experimental Eye Research. 2015 September; 138: 66-69. doi: 10.1016/j.exer.2015.06.030. PMID: 26142954.


  • Bu P, Vin AP, Sethupathi P, Ambrecht LA, Zhai YG, Nikolic N, Qiao L, Bouchard CS. Effects of Activated Omental Cells on Rat Limbal Corneal Alkali Injury. Experimental Eye Research. 2014 April; 121:143-146. doi: 10.1016/j.exer.2014.02.014. PMID: 24582890.


  • Vin AP, Hu HB, Zhai YG, Von Zee CL, Logeman A, Stubbs Jr. EB, Perlman, JI, Bu P. Neuroprotective effect of resveratrol prophylaxis on experimental retinal ischemic injury. Experimental Eye Research. 2013 March; 108: 72-75. doi: 10.1016/j.exer.2012.11.022. PMID: 23287437.