• Associate Professor
  • Ophthalmology

Health Sciences Library Discover Research Network | ResearchGate | Google Scholar



B.S., Vision Science - Illinois College of Optemetry, Chicago, IL

Optometry School:

O.D., - Illinois College of Optometry, Chicago, IL


Optometric Residency in Primary Eye Care - Department of Veteran Affairs Medical Center, Newinton, Conneticut


M.S., Pharmacology - Indiana University, Bloomington, IN

Pharm.D. - University of Illinois at Chicago, Chicago, IL

Research Focus: Opthalmic Research, Retina, Glaucoma, Eye related biomarkers of neurodegenerative disease, Capillaroscopic assessment of ocular and systemic disease 

Summary of Research Interests

My work includes use of orthogonal polarization spectral imaging adapted for use in the eye to generate hemorheological flow matrices applicable to the treatment of coagulopathy. Our current work expands prior ocular hemorheological research by development of a unique lab-on-chip device to replicate pressure and flow relationships found in patients with glaucoma, and which can be extended to improve drug treatment strategy for glaucoma clinically. I am also involved in the investigation of how pupil responses may be used to optimize drug treatment for neurodegenerative disorders such as Parkinson’s disease 



  • Patel N, Duong S, Mirbod P, Xu J. Gaynes BI. A meta-analysis of variability in conjunctival microvascular hemorheology metrics. Microvascular Research. 2022 February; 142:104340. doi: 10.1016/j.mvr.2022.104340. PMID: 35151720.
  • Gaynes BI, Shapiro MD, Augustine AS, Xu Y, Lin Y, Mirbod P, Dieter RS, Cheng Y, Wu M, Venkataraman H, Gao Y, Petrov P, Xu J. Hierarchical data visualization of experimental erythrocyte aggregation employing cross correlation and optical flow applications. Microvascular Research. 2022 May; 143:104386. doi: 10.1016/j.mvr.2022.104386. Epub ahead of print. PMID: 35623407.
  • Gaynes BI, ACCP Public Policy Committee. Over-the-Counter Epinephrine for Asthma Treatment: Too Much Risk for Too Little Benefit. Journal of Clinical Pharmacology. 2022 September. 0(0) 1–3. doi: 10.1002/jcph.2146. Epub ahead of print. PMID: 36057794.
  • Hakim R, Patel N, Veryovkin I, Gaynes BI. Effect of Age and Viscosity on Duration of Corneal Anesthesia with Topical 2% Lidocaine Administration. J Ocul Pharmacol Ther. 2022 Dec;38(10):709-716. doi: 10.1089/jop.2022.0076. Epub 2022 Nov 14. PMID: 36374966.


  • Gaynes BI, Zaffer A, Yousefzai R, Chazaro-Cortes M, Colletta K, Kletzel SL, Jost MB, Park Y, Chawla J, Albert MV, Xiao T. Variable abnormality of the melanopsin-derived portion of the pupillary light reflex (PLR) in patients with Parkinson's disease (PD) and parkinsonism features. Neurological Sciences. 2021 May; doi: 10.1007/s10072-021-05245-8. Epub ahead of print. PMID: 33945034.
  • Tabashum T, Zaffer A, Yousefzai R, Colletta K, Jost MB, Park Y, Chawla J, Albert MV, Gaynes BI, Xiao T. Detection of Parkinson's Disease through Automated Pupil Tracking of the Post-illumination Pupillary Response. Frontiers in Medicine. 2021 March; 8: 316. PMID: 33842509. PMCID: PMC8026862.
  • Gao Y, Wu M, Gaynes BI, Dieter RS, Xu J. Study of ultrasound thrombolysis using acoustic bubbles in a microfluidic device. Lab Chip. 2021 August; doi: 10.1039/d1lc00276g. PMID: 34350927.
  • Gaynes BI. Treatment Strategies for Dry Eye Disease: What the Pharmacist Needs to Know. Pharmacy Times Continuing Education. 2021 September.
  • Pai SM, Othman AA, Rusch L, Masters JC, Greene D, Rogge M, Gries JM, Clementi W, Kumar P, Younis I, Salem AH, Gaynes BI, Pastino G, Derendorf H, Public Policy Committee of the American College of Clinical Pharmacology. Science and Evidence-Based Review and Approval of COVID-19 Vaccines: A Statement of Support for the US FDA. Journal of Clinical Pharmacology. 2021 March. 61(3): 277-279. doi: 10.1002/jcph.1794. PMID: 33274473. PMCID: PMC7754558.


  • Pai SM, Othman AA, Rusch L, Masters JC, Greene D, Rogge M, Gries JM, Clementi W, Kumar P, Younis I, Salem AH, Gaynes BI, Pastino G, Derendorf H. Science and Evidence-based Review and Approval of COVID-19 Vaccines: A Statement of Support for the U.S. FDA. Journal of Clinical Pharmacology. 2020 December; 61(3):277-279.


  • Thompson JM, Truong AH, Stern HD, Djalilian A, Cortina MS, Tu EY, Johnson P, Verdier DD, Rafo L, Lubeck D, Spektor T, Jorgensen C, Rubenstein JB, Majmudar PA, Talati R, Basti S, Feder R, Sugar A, Mian SI, Balasubramanian N, Sandhu J, Gaynes BI, Bouchard CS. A Multicenter Study Evaluating the Risk Factors and Outcomes of Repeat Descemet Stripping Endothelial Keratoplasty. Cornea. 2019 February; 38(2): 177-182. doi: 10.1097/ICO.0000000000001817. PMID: 30615600.
  • Salinger CL, Gaynes BI, Rajpal RK. Innovations in Topical Ocular Corticosteroid Therapy for the Management of Postoperative Ocular Inflammation and Pain. American Journal of Medical Care. 2019 July; 25: S215-S226. PMID: 31419092.
  • Andino D, Moy J, Gaynes BI. Serum vitamin A, zinc and visual function in children with moderate to severe persistent asthma. Journal of Asthma. 2019 November; 56(11): 1198-1203. doi: 10.1080/02770903.2018.1531992. PMID: 30380955.


  • Andino D, Moy J, Gaynes BI. Serum vitamin A, zinc and visual function in children with moderate to severe persistent asthma. Journal of Asthma. 2018 October; 56(11): 1-6. doi: 10.1080/02770903.2018.1531992.


  • Valeshabad AK, Wanek J, Saraf SL, Gaynes BI, Gordeuk VR, Molokie RE, Shahidi M. Changes in Conjunctival Hemodynamics Predict Albuminuria in Sickle Cell Nephropathy. American Journal of Nephrology. 2015 August; 41(6):487-493. doi: 10.1159/000438678. PMCID: PMC4561023.
  • Valeshabad AK, Wanek J, Gaynes BI, Saraf SL, Molokie R, Shahidi M. Conjunctival microvascular hemodynamics following vaso-occlusive crisis in sickle cell disease. Clinical Hemorheology and Microcirculation. 2015 September; 62(4): 359-367. doi: 10.3233/CH-151977. PMID: 26444608.
  • Spektor T,  Nikolic N,  Lekakh  O, Gaynes BI. Efficacy of ScripTalk automated prescription label reader and veterans with visual impairments. Journal of Visual Impairment & Blindness. 2015 September. 109(5): 412-418.
  • Iqbal O, Bramble W, Ottman A, O’Malley P, Gaynes J, De Alba F, Gaynes BI, Fareed J, Bouchard CS. Aspirin and its Metabolites Enhance the Expression of Vascular Endothelial Growth Factor in Retinal Pigment Epithelial Cell Cultures – Implications in the Pathophysiology of Age-Related Macular Degeneration. International Journal of Ophthalmology and Eye Science.2015 August. 3(7), 115-120. doi:


  • Gaynes, BI. Statins and Cataract. JAMA Ophthalmology. 2014 March; 132(3): 362-363. doi: 10.1001/jamaophthalmol.2013.8265. PMID: 24626831.
  • Gaynes BI. Efficient bottle adaptation provides for adjustment of ophthalmic drop volume and drug dosage. Clinical and Experimental Ophthalmology. 2014 March. 42(7): 704-705. doi: 10.1111/ceo.12312. PMID: 24612119.