James McDonnell MD

  • Professor
  • Vice Chair of Clinical Affairs
  • Ophthalmology

 

 

Credentials

Undergraduate:

A.B. - English Literature, Georgetown University, Washington, DC

Graduate:

Film and TV - Catholic University, Washington, DC

Post-Baccalaureate - Georgetown University, Washington, DC

Medical School:

M.D. - Northwestern University Medical School, Chicago, IL

Residency:

Combined Residency - Emergency & Internal Medicine, Northwestern University Medical Center, Chicago, IL

Residency in Ophthalmology, The Eye Institute, Medical College of Wisconsin, Milwaukee, WI

Additional Training:

Pediatric Ophthalmology Fellowship, University of Wisconsin, Madison, WI

Research Focus: Pediatric Ophthalmology, Retina

Summary of Research Interests

My research interest involves exploring the neuroprotective effect of natural compounds in ischemic and light-induced injury.  We have employed a rat model of retinal ischemia as well as phototoxicity to study the protective effects of compounds such as resveratrol, sulphoraphane, Kaempferol, (and even AZT) in ischemia and reperfusion injury as well as in phototoxic injury of retinal tissue. 

Publications

2022

  • Noguchi JL, Seu MY, Qiao JB, Tan IR, Swaminathan SR, McDonnell JF, Tan Z, Bu P. Kaempferol Protects Against Retinal Photoreceptor Degeneration in a Mouse Model of Light-Induced Retinal Injury. J Ocul Pharmacol Ther. 2022 Dec 14. doi: 10.1089/jop.2022.0128. Epub ahead of print. PMID: 36520599.
     

2021

  • Gange WS, Qiao JB, Park PJ, McDonnell JF, Tan Z, Perlman JI, Bu P. Protection of Retinal Function by Nucleoside Reverse Transcriptase Inhibitors Following Retinal Ischemia/Reperfusion Injury. Journal of Ocular Pharmacology and Therapeutics. 2021 October; 37(8):485-491. doi: 10.1089/jop.2020.0083. PMID: 34448620.

2020

  • Estes K, Parrish RK, Sinacore J, Mumby PB, McDonnell JF. Effects of corrective strabismus surgery on social anxiety and self-consciousness in adults. Journal of American Association for Pediatric Ophthalmology and Strabismus. 2020 October; 24(5): 280.e1-280.e4. doi: 10.1016/j.jaapos.2020.05.017. PMID: 33038493.

2015

  • Ambrecht LA, Perlman JI, McDonnell JF, Zhai YG, Qiao L, Bu P. Protection of Retinal Function by Sulforaphane Following Retinal Ischemic Injury. Experimental Eye Research. 2015 September; 138: 66-69. doi: 10.1016/j.exer.2015.06.030. PMID: 26142954.

2003

  • Muraskas JK, McDonnell JF, Chudik RJ, Salyer KE, Glynn L. Amniotic band syndrome with significant orofacial clefts and disruptions and distortions of craniofacial structures. Journal of Pediatric Surgery. 2003 April; 38(4): 635-638. doi: 10.1053/jpsu.2003.50141. PMID: 12677585.

2002

  • Bouchard CS, Wood CF, Banich AM, McDonnell JF. Layered Pre-Descemet Intracorneal Hemorrhage in a Patient with End-Stage Glaucoma. Annals of Ophthalmology. 2002 December; 34: 224-225. https://doi.org/10.1007/s12009-002-0081-x.
  • McDonnell JF, Ramonas K, Park AH. Pediatric Horner's syndrome due to a cervical thymic rest. Journal of Pediatric Ophthalmology Strabismus. 2002 May-June; 39(3): 185-186. PMID: 12051288.

2001

  • Bouchard CS, Morno K, Perkins J, McDonnell JF, Dicken F. Ocular complications of thermal injury: a 3-year restrospective. Journal of Trauma. 2001 January; 50(1): 79-82. doi: 10.1097/00005373-200101000-00014. PMID: 11231674.

2000

  • Skolnick KA, McDonnell JF. Spontaneous dural cavernous sinus fistula in a child. Journal of American Association for Pediatric Ophthalmology and Strabismus. 2000 December; 4(6): 383-385. doi: 10.1067/mpa.2000.110341. PMID: 11124678.