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Scott Cotler
Primary Department
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Hepatitis B
Other causes of chronic liver disease
Liver cancer
Hepatitis C
Loyola Outpatient Center
Loyola Center for Health at Burr Ridge
Loyola Hepatology Clinic in Chinatown
Loyola Hepatology Clinic in Moline
Loyola Hepatology Clinic in Peoria
Loyola Hepatology Clinic in Rockford
Transplant Hepatology, American Board of Internal Medicine Subspecialty
American Board of Internal Medicine
American Board of Internal Medicine Subspecialty Gastroenterology
Medical School
University of Chicago Pritzker School of Medicine
University of Chicago Medical Center, Internal Medicine: General
Rush-Presbyterian-St. Luke's Medical Center, Internal Medicine: Gastroenterology
University of Washington Medical Center, Internal Medicine: Hepatology
Khan,M. W.; Ding,X.; Cotler,S. J.; Clarke,M.; Layden,B. T.Studies on the Tissue Localization of HKDC1, a Putative Novel Fifth Hexokinase, in Humans The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2018 ;66(5):385-392
Major, M; Gutfraind, A; Shekhtman, L; Cui, Q; Kachko, A; Cotler, SJ; Hajarizadeh, B; Sacks-Davis, R; Page, K; Boodram, B; Dahari, HModeling of patient virus titers suggests that availability of a vaccine could reduce hepatitis C virus transmission among injecting drug users. Science translational medicine 2018 ;10(449)
Wang, F; Bank, T; Malnassy, G; Arteaga, M; Shang, N; Dalheim, A; Ding, X; Cotler, SJ; Denning, MF; Nishimura, MI; Breslin, P; Qiu, WInhibition of insulin-like growth factor 1 receptor enhances the efficacy of sorafenib in inhibiting hepatocellular carcinoma cell growth and survival. Hepatology communications 2018 ;2(6)
Loy, VM; Joyce, C; Bello, S; VonRoenn, N; Cotler, SJGender disparities in liver transplant candidates with nonalcoholic steatohepatitis. Clinical transplantation 2018 ;
Venepalli, NK; Modayil, MV; Berg, SA; Nair, TD; Parepally, M; Rajaram, P; Gaba, RC; Bui, JT; Huang, Y; Cotler, SJFeatures of hepatocellular carcinoma in Hispanics differ from African Americans and non-Hispanic Whites. WORLD JOURNAL OF HEPATOLOGY 2017 ;9(7)
Goyal,A.; Lurie,Y.; Meissner,E. G.; Major,M.; Sansone,N.; Uprichard,S. L.; Cotler,S. J.; Dahari,H.Modeling HCV cure after an ultra-short duration of therapy with direct acting agents Antiviral Research 2017 ;144:281-285
Canini,L.; Imamura,M.; Kawakami,Y.; Uprichard,S. L.; Cotler,S. J.; Dahari,H.; Chayama,K.HCV kinetic and modeling analyses project shorter durations to cure under combined therapy with daclatasvir and asunaprevir in chronic HCV-infected patients PLoS ONE 2017 ;12(12):e0187409
Canini,L.; Koh,C.; Cotler,S. J.; Uprichard,S. L.; Winters,M. A.; Han,M. A. T.; Kleiner,D. E.; Idilman,R.; Yurdaydin,C.; Glenn,J. S.; Heller,T.; Dahari,H.Pharmacokinetics and pharmacodynamics modeling of lonafarnib in patients with chronic hepatitis delta virus infection Hepatology communications 2017 ;1(4):288-292
Malespin,M.; Benyashvili,T.; Uprichard,S. L.; Perelson,A. S.; Dahari,H.; Cotler,S. J.Prevalence of end of treatment RNA-positive/sustained viral response in HCV patients treated with sofosbuvir combination therapies Therapeutic advances in gastroenterology 2017 ;10(1):68-73
Shteyer,E.; Dahari,H.; Gafanovich,I.; Dery,I.; Wolf,D.; Cotler,S. J.; Lurie,Y.End of treatment RNA-positive/sustained viral response in an individual with acute hepatitis C virus infection treated with direct-acting antivirals Therapeutic advances in gastroenterology 2017 ;10(5):429-430
Malespin, M; Moore, CM; Fialho, A; de Melo, SW; Benyashvili, T; Kothari, AN; di Sabato, D; Kallwitz, ER; Cotler, SJ; Lu, ADCase Series of 10 Patients with Cirrhosis Undergoing Emergent Repair of Ruptured Umbilical Hernias: Natural History and Predictors of Outcomes. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 2017 ;
Parrinello,C. M.; Rudolph,B. J.; Lazo,M.; Gallo,L. C.; Thyagarajan,B.; Cotler,S. J.; Qi,Q.; Seeherunvong,T.; Vidot,D. C.; Strickler,H. D.; Kaplan,R. C.; Isasi,C. R.Associations of Insulin Resistance and Glycemia With Liver Enzymes in Hispanic/Latino Youths: Results From the Hispanic Community Children's Health Study/Study of Latino Youth (SOL Youth) Journal of clinical gastroenterology 2017 ; :
Kothari,A. N.; Loy,V. M.; Brownlee,S. A.; Ezure,Y.; Schaidle-Blackburn,C.; Cotler,S. J.; di Sabato,D.; Kuo,P. C.; Lu,A. D.Adverse Effect of Post-Discharge Care Fragmentation on Outcomes after Readmissions after Liver Transplantation Journal of the American College of Surgeons 2017 ; :
Raffield,L. M.; Louie,T.; Sofer,T.; Jain,D.; Ipp,E.; Taylor,K. D.; Papanicolaou,G. J.; Aviles-Santa,L.; Lange,L. A.; Laurie,C. C.; Conomos,M. P.; Thornton,T. A.; Chen,Y. I.; Qi,Q.; Cotler,S.; Thyagarajan,B.; Schneiderman,N.; Rotter,J. I.; Reiner,A. P.; Lin,H. J.Genome-wide association study of iron traits and relation to diabetes in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): potential genomic intersection of iron and glucose regulation? Human molecular genetics 2017 ;26(10):1966-1978
Scaglione,S. J.; Metcalfe,L.; Kliethermes,S.; Vasilyev,I.; Tsang,R.; Caines,A.; Mumtaz,S.; Goyal,V.; Khalid,A.; Shoham,D.; Markossian,T.; Luke,A.; Underwood,H.; Cotler,S. J.Early Hospital Readmissions and Mortality in Patients With Decompensated Cirrhosis Enrolled in a Large National Health Insurance Administrative Database Journal of clinical gastroenterology 2017 ; :
Breslin,P.; Kuo,P.; Ding,X.; Cotler,S.; Nishimura,M.; Zhang,J.; Qiu,W.; Arteaga,M.; Zaidi,A.; Shang,N.FAK kinase activity is required for the progression of c-Met/beta-catenin-driven HCC Gene expression 2016 ; :
Dahari,H.; Canini,L.; Graw,F.; Uprichard,S. L.; Araujo,E. S.; Penaranda,G.; Coquet,E.; Chiche,L.; Riso,A.; Renou,C.; Bourliere,M.; Cotler,S. J.; Halfon,P.HCV kinetic and modeling analyses indicate similar time to cure among sofosbuvir combination regimens with daclatasvir, simeprevir or ledipasvir Journal of Hepatology 2016 ; :
Dahari,H.; Cotler,S. J.; Feld,J. J.Cure prevents more than transmission of HCV Hepatology (Baltimore, Md.) 2016 ; :
Dahari,H.; Halfon,P.; Cotler,S. J.Resurrection of response-guided therapy for sofosbuvir combination therapies Journal of Hepatology 2016 ; :
Duarte-Rojo, A; Fischer, SE; Adeyi, O; Zita, D; Deneke, MG; Selzner, N; Chen, L; Malespin, M; Cotler, SJ; McGilvray, ID; Feld, JJProtease inhibitors partially overcome the interferon nonresponse phenotype in patients with chronic hepatitis C. Journal of viral hepatitis 2016 ;23(5)
Dam,L.; Cheng,A.; Tran,P.; Wong,S. S.; Hershow,R.; Cotler,S.; Cotler,S. J.Hepatitis B Stigma and Knowledge among Vietnamese in Ho Chi Minh City and Chicago Canadian journal of gastroenterology & hepatology 2016 ;2016:1910292
Dam,L.; Cheng,A.; Tran,P.; Wong,S. S.; Hershow,R.; Cotler,S.; Cotler,S. J.Hepatitis B Stigma and Knowledge among Vietnamese in Ho Chi Minh City and Chicago Canadian journal of gastroenterology & hepatology 2016 ;2016:1910292
Kataria,Y.; Deaton,R. J.; Enk,E.; Jin,M.; Petrauskaite,M.; Dong,L.; Goldenberg,J. R.; Cotler,S. J.; Jensen,D. M.; van Breemen,R. B.; Gann,P. H.Retinoid and carotenoid status in serum and liver among patients at high-risk for liver cancer BMC GASTROENTEROLOGY 2016 ;16(1):30-016-0432-5
Hasin,Y.; Shteingart,S.; Dahari,H.; Gafanovich,I.; Floru,S.; Braun,M.; Shlomai,A.; Verstandig,A.; Dery,I.; Uprichard,S. L.; Cotler,S. J.; Lurie,Y.Hepatitis C virus cures after direct acting antiviral-related drug-induced liver injury: Case report WORLD JOURNAL OF HEPATOLOGY 2016 ;8(20):858-862
Kliethermes,S.; Ma,M.; Purtell,C.; Balasubramanian,N.; Gonzalez,B.; Layden,T. J.; Cotler,S. J.An assessment of racial differences in the upper limits of normal ALT levels in children and the effect of obesity on elevated values Pediatric obesity 2016 ; :
Loy,V.; Benyashvili,T.; Adams,W.; Pavkov,D.; O'Mahoney,M.; Cotler,S. J.The time and cost investment required to obtain and initiate direct-acting antiviral therapy ANTIVIRAL THERAPY 2016 ; :
Cellar, DF; Voster, D; Fetters, R; Twitchell, E; Harper, GW; Scott, CPersonality, Coping, and Well-Being for People Living with Chronic Hepatitis C. Psychological reports 2016 ;118(2)
Arteaga,M.; Shang,N.; Ding,X.; Yong,S.; Cotler,S. J.; Denning,M. F.; Shimamura,T.; Breslin,P.; Luscher,B.; Qiu,W.Inhibition of SIRT2 suppresses hepatic fibrosis American journal of physiology.Gastrointestinal and liver physiology 2016 ;310(11):G1155-68
Malespin,M.; Sleesman,B.; Lau,A.; Wong,S. S.; Cotler,S. J.Prevalence and correlates of suspected nonalcoholic fatty liver disease in Chinese American children Journal of clinical gastroenterology 2015 ;49(4):345-349
Koh,C.; Canini,L.; Dahari,H.; Zhao,X.; Uprichard,S. L.; Haynes-Williams,V.; Winters,M. A.; Subramanya,G.; Cooper,S. L.; Pinto,P.; Wolff,E. F.; Bishop,R.; Ai Thanda Han,M.; Cotler,S. J.; Kleiner,D. E.; Keskin,O.; Idilman,R.; Yurdaydin,C.; Glenn,J. S.; Heller,T.Oral prenylation inhibition with lonafarnib in chronic hepatitis D infection: a proof-of-concept randomised, double-blind, placebo-controlled phase 2A trial The Lancet.Infectious diseases 2015 ;15(10):1167-1174
Guedj, J; Canini, L; Cotler, S; Dahari, HReply: To PMID 25098971. Hepatology (Baltimore, Md.) 2015 ;61(6)
Canini, L; DebRoy, S; MariƱo, Z; Conway, JM; Crespo, G; Navasa, M; D'Amato, M; Ferenci, P; Cotler, SJ; Forns, X; Perelson, AS; Dahari, HSeverity of liver disease affects HCV kinetics in patients treated with intravenous silibinin monotherapy. ANTIVIRAL THERAPY 2015 ;20(2)
Jung,M.; Kuniholm,M. H.; Ho,G. Y.; Cotler,S.; Strickler,H. D.; Thyagarajan,B.; Youngblood,M.; Kaplan,R. C.; Del Amo,J.The distribution of Hepatitis B virus exposure and infection in a population-based sample of US Hispanic adults Hepatology (Baltimore, Md.) 2015 ; :
Echevarria,D.; Gutfraind,A.; Boodram,B.; Major,M.; Del Valle,S.; Cotler,S. J.; Dahari,H.Mathematical Modeling of Hepatitis C Prevalence Reduction with Antiviral Treatment Scale-Up in Persons Who Inject Drugs in Metropolitan Chicago PLoS ONE 2015 ;10(8):e0135901
Shang,N.; Arteaga,M.; Zaidi,A.; Stauffer,J.; Cotler,S. J.; Zeleznik-Le,N. J.; Zhang,J.; Qiu,W.FAK is required for c-Met/beta-catenin-driven hepatocarcinogenesis Hepatology (Baltimore, Md.) 2015 ;61(1):214-226
Kallwitz,E. R.; Daviglus,M. L.; Allison,M. A.; Emory,K. T.; Zhao,L.; Kuniholm,M. H.; Chen,J.; Gouskova,N.; Pirzada,A.; Talavera,G. A.; Youngblood,M. E.; Cotler,S. J.Prevalence of suspected nonalcoholic fatty liver disease in Hispanic/Latino individuals differs by heritage Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2015 ;13(3):569-576
Dahari,H.; Shteingart,S.; Gafanovich,I.; Cotler,S. J.; D'Amato,M.; Pohl,R. T.; Weiss,G.; Ashkenazi,Y. J.; Tichler,T.; Goldin,E.; Lurie,Y.Sustained virological response with intravenous silibinin: individualized IFN-free therapy via real-time modelling of HCV kinetics Liver international : official journal of the International Association for the Study of the Liver 2015 ;35(2):289-294
Gaba, RC; Kallwitz, ER; Parvinian, A; Bui, JT; Von Roenn, NM; Berkes, JL; Cotler, SJImaging surveillance and multidisciplinary review improves curative therapy access and survival in HCC patients. Annals of hepatology 2014 ;12(5)
Kuniholm, MH; Jung, M; Everhart, JE; Cotler, S; Heiss, G; McQuillan, G; Kim, RS; Strickler, HD; Thyagarajan, B; Youngblood, M; Kaplan, RC; Ho, GYPrevalence of hepatitis C virus infection in US Hispanic/Latino adults: results from the NHANES 2007-2010 and HCHS/SOL studies. The Journal of infectious diseases 2014 ;209(10)
Guedj,J.; Rotman,Y.; Cotler,S. J.; Koh,C.; Schmid,P.; Albrecht,J.; Haynes-Williams,V.; Liang,T. J.; Hoofnagle,J. H.; Heller,T.; Dahari,H.Understanding early serum hepatitis D virus and hepatitis B surface antigen kinetics during pegylated interferon-alpha therapy via mathematical modeling Hepatology (Baltimore, Md.) 2014 ;60(6):1902-1910
Dahari,H.; Cotler,S. J.Individualized treatment for patients with low HCV load (genotype 1): a viral kinetic approach Hepatology (Baltimore, Md.) 2014 ;59(6):2422-2423
Casadaban,L.; Malespin,M.; Cheung,A.; McGuffey,R. A.; Boulay,B. R.; Halline,A. G.; Brown,R. D.; Cotler,S. J.; Jeon,H.; Bui,J. T.; Gaba,R. C.Presurgical transarterial chemoembolization does not increase biliary stricture incidence in orthotopic liver transplant patients Transplantation proceedings 2014 ;46(5):1413-1419
Sun, S; Song, Z; Cotler, SJ; Cho, MBiomechanics and functionality of hepatocytes in liver cirrhosis. Journal of Biomechanics 2014 ;47(9)
Layden,J. E.; Tayo,B. O.; Cotler,S. J.; Clark,N. M.; Baraoidan,K.; Friedman,S. L.; Cooper,R. S.Association of genetic variants with rapid fibrosis: progression after liver transplantation for hepatitis C Transplantation 2014 ;97(10):1072-1078
Gaba,R. C.; Couture,P. M.; Bui,J. T.; Knuttinen,M. G.; Walzer,N. M.; Kallwitz,E. R.; Berkes,J. L.; Cotler,S. J.Prognostic capability of different liver disease scoring systems for prediction of early mortality after transjugular intrahepatic portosystemic shunt creation Journal of vascular and interventional radiology : JVIR 2013 ;24(3):411-20, 420.e1-4; quiz 421
Kallwitz,E. R.; Loy,V.; Mettu,P.; Von Roenn,N.; Berkes,J.; Cotler,S. J.Physical activity and metabolic syndrome in liver transplant recipients Liver Transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2013 ;19(10):1125-1131
Yap,F. Y.; Bui,J. T.; Knuttinen,M. G.; Walzer,N. M.; Cotler,S. J.; Owens,C. A.; Berkes,J. L.; Gaba,R. C.Quantitative morphometric analysis of hepatocellular carcinoma: development of a programmed algorithm and preliminary application Diagnostic and interventional radiology (Ankara, Turkey) 2013 ;19(2):97-105
Dahari,H.; Cotler,S. J.; Layden,T. J.; Perelson,A. S.Understanding triphasic HCV decline during treatment in the era of IL28B polymorphisms and direct acting antiviral agents via mathematical modeling Journal of Hepatology 2013 ;58(4):840-842
Guedj,J.; Dahari,H.; Rong,L.; Sansone,N. D.; Nettles,R. E.; Cotler,S. J.; Layden,T. J.; Uprichard,S. L.; Perelson,A. S.Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life Proceedings of the National Academy of Sciences of the United States of America 2013 ;110(10):3991-3996
Goyal, L; Supko, JG; Berlin, J; Blaszkowsky, LS; Carpenter, A; Heuman, DM; Hilderbrand, SL; Stuart, KE; Cotler, S; Senzer, NN; Chan, E; Berg, CL; Clark, JW; Hezel, AF; Ryan, DP; Zhu, AXPhase 1 study of N(1),N(11)-diethylnorspermine (DENSPM) in patients with advanced hepatocellular carcinoma. CANCER CHEMOTHERAPY AND PHARMACOLOGY 2013 ;72(6)
Malespin,M.; Wong,S.; Siqueira,F.; Luc,B.; Ravaee,B.; Vainder,C.; Cotler,S. J.Barriers to treatment of hepatitis B in an urban Chinatown community Journal of clinical gastroenterology 2012 ;46(8):e66-70
Layden,J. E.; Cotler,S.; Brown,K. A.; Lucey,M. R.; Te,H. S.; Eswaran,S.; Fimmel,C.; Layden,T. J.; Clark,N. M.Racial differences in fibrosis progression after HCV-related liver transplantation Transplantation 2012 ;94(2):178-184
Cotler,S. J.; Cotler,S.; Xie,H.; Luc,B. J.; Layden,T. J.; Wong,S. S.Characterizing hepatitis B stigma in Chinese immigrants Journal of viral hepatitis 2012 ;19(2):147-152
Cotler,S. J.; Cotler,S.; Xie,H.; Luc,B. J.; Layden,T. J.; Wong,S. S.Characterizing hepatitis B stigma in Chinese immigrants Journal of viral hepatitis 2012 ;19(2):147-152
Gaba,R. C.; Omene,B. O.; Podczerwinski,E. S.; Knuttinen,M. G.; Cotler,S. J.; Kallwitz,E. R.; Berkes,J. L.; Walzer,N. M.; Bui,J. T.; Owens,C. A.TIPS for treatment of variceal hemorrhage: clinical outcomes in 128 patients at a single institution over a 12-year period Journal of vascular and interventional radiology : JVIR 2012 ;23(2):227-235
Layden,J. E.; Cotler,S. J.; Grim,S. A.; Fischer,M. J.; Lucey,M. R.; Clark,N. M.Impact of donor and recipient race on survival after hepatitis C-related liver transplantation Transplantation 2012 ;93(4):444-449
Tencate,V.; Sainz,B.,Jr; Cotler,S. J.; Uprichard,S. L.Potential treatment options and future research to increase hepatitis C virus treatment response rate Hepatic medicine : evidence and research 2010 ;2010(2):125-145
Venu,M.; Brown,R. D.; Lepe,R.; Berkes,J.; Cotler,S. J.; Benedetti,E.; Testa,G.; Venu,R. P.Laboratory diagnosis and nonoperative management of biliary complications in living donor liver transplant patients Journal of clinical gastroenterology 2007 ;41(5):501-506
Bogetti,D.; Jarzembowski,T. M.; Sankary,H. N.; Manzelli,A.; Knight,P. S.; Chejfec,G.; Cotler,S.; Oberholzer,J.; Testa,G.; Benedetti,E.Hepatic ischemia/reperfusion injury can be modulated with thymoglobulin induction therapy. Transplantation proceedings 2005 ;37(1):404-406
Bogetti,D.; Sankary,H. N.; Jarzembowski,T. M.; Manzelli,A.; Knight,P. S.; Thielke,J.; Chejfec,G.; Cotler,S.; Oberholzer,J.; Testa,G.; Benedetti,E.Thymoglobulin induction protects liver allografts from ischemia/reperfusion injury. Clinical transplantation 2005 ;19(4):507-511