Retina Injury Protection: Animal Models
- Ischemic/reperfusion injury model
- Light induced injury model
We have conducted basic science research in different animals to evaluate how to protect the retina with different chemical compounds from various injuries including genetic, light induced and vascular (blood flow impairment) injuries. This research can help develop new treatments that can help to treat various retinal diseases.
Research Team
Publications
- Noguchi JL, Seu MY, Qiao JB, Tan IR, Swaminathan SR, McDonnell JF, Tan Z, Bu P. Kaempferol Protects Against Retinal Photoreceptor Degeneration in a Mouse Model of Light-Induced Retinal Injury. J Ocul Pharmacol Ther. 2023 Jan-Feb;39(1):80-85. doi: 10.1089/jop.2022.0128. Epub 2022 Dec 14. PMID: 36520599.
- Losenkova K, Takeda A, Ragauskas S, Cerrada-Gimenez M, Vähätupa M, Kaja S, Paul ML, Schmies CC, Rolshoven G, Müller CE, Sandholm J, Jalkanen S, Kalesnykas G, Yegutkin GG. CD73 controls ocular adenosine levels and protects retina from light-induced phototoxicity. Cell Mol Life Sci. 2022 Feb 25;79(3):152. doi: 10.1007/s00018-022-04187-4. PMID: 35212809; PMCID: PMC8881442.
- Lelyte I, Ahmed Z, Kaja S, Kalesnykas G. Structure-Function Relationships in the Rodent Streptozotocin-Induced Model for Diabetic Retinopathy: A Systematic Review. J Ocul Pharmacol Ther. 2022 May;38(4):271-286. doi: 10.1089/jop.2021.0128. Epub 2022 Mar 22. PMID: 35325558; PMCID: PMC9125572.
- Gange WS, Qiao JB, Park PJ, McDonnell JF, Tan Z, Perlman JI, Bu P. Protection of Retinal Function by Nucleoside Reverse Transcriptase Inhibitors Following Retinal Ischemia/Reperfusion Injury. Journal of Ocular Pharmacology and Therapeutics. 2021 October; 37(8):485-491. doi: 10.1089/jop.2020.0083. PMID: 34448620.
- Maciulaitiene R, Pakuliene G, Kaja S, Pauza DH, Kalesnykas G, Januleviciene I. Glioprotection of Retinal Astrocytes After Intravitreal Administration of Memantine in the Mouse Optic Nerve Crush Model. Medical Science Monitor. 2017 March; 23: 1173-79. doi: 10.12659/msm.899699. PMCID: PMC5352005.
- Kaja S, Payne AJ, Naumchuk N, Koulen P. Quantification of Lactate Dehydrogenase for Cell Viability Testing Using Cell Lines and Primary Cultured Astrocytes. Current Protocols in Toxicology. 2017 May; 72(1): 2.26.1- 2.26.10. doi: 10.1002/cptx.21. PMCID: PMC5501254.
- Kang K, Tarchick MJ, Yu XS, Beight C, Bu P, Yu MZ. Carnosic acid slows photoreceptor degeneration in the Pde6brd10 mouse model of retinitis pigmentosa. Scientific Reports. 2016 March; 6:22632. doi: 10.1038/srep22632. PMCID: PMC4785376.
- Yu MZ, Kang K, Bu P, Bell BA, Kaul C, Qiao JB, Sturgill-Short G, Yu XS, Tarchick MJ, Beight C, Zhang SX, Peachey NS. Deficiency of CC Chemokine Ligand 2 and Decay-accelerating Factor Causes Retinal Degeneration in Mice. Experimental Eye Research. 2015 September; 138: 126-133. doi: 10.1016/j.exer.2015.05.016. PMCID: PMC5509212.
- Ambrecht LA, Perlman JI, McDonnell JF, Zhai YG, Qiao L, Bu P. Protection of Retinal Function by Sulforaphane Following Retinal Ischemic Injury. Experimental Eye Research. 2015 September; 138: 66-69. doi: 10.1016/j.exer.2015.06.030. PMID: 26142954.
- Kaja S, Shah AA, Haji SA, Patel KB, Naumchuk Y, Zabaneh A, Gerdes BC, Kunjukunju N, Sabates NR, Cassell MA, Lord RK, Pikey KP, Poulose A, Koulen P. Nampt/PBEF/visfatin serum levels – a new biomarker for retinal blood vessel occlusions. Clinical Ophthalmology. 2015 April, 9: 611-18. doi: 10.2147/OPTH.S80784. PMCID: PMC4396426.
- Vin AP, Hu HB, Zhai YG, Von Zee CL, Logeman A, Stubbs Jr. EB, Perlman, JI, Bu P. Neuroprotective effect of resveratrol prophylaxis on experimental retinal ischemic injury. Experimental Eye Research. 2013 March; 108: 72-75. doi: 10.1016/j.exer.2012.11.022. PMID: 23287437.
Age Related Macular Degeneration (AMD)
We have conducted basic science research in different animals to evaluate how to protect the retina with different chemical compounds from various injuries including genetic, light induced and vascular (blood flow impairment) injuries. This research can help develop new treatments that can help to treat various retinal diseases.
Research Team
Publications
- Acevedo-Jake A, Shi S, Siddiqui Z, Sanyal S, Schur R, Kaja S, Yuan A, Kumar VA. Preclinical Efficacy of Pro- and Anti-Angiogenic Peptide Hydrogels to Treat Age-Related Macular Degeneration. Bioengineering(Basel). 2021 November; 8(12): 190. DOI: 10.3390/bioengineering8120190. PMID: 34940343. PMCID: PMC8698576.
- Adams N, Iqbal O, de Alba F, Kuffel G, Zilliox M, Bouchard C et al. Genetic Polymorphisms Associated with Risk of Developing Age-Related Macular Degeneration in Patients with Chronic Aspirin Usage. Journal of Ophthalmology and Eye Care 2018 May; 1(1): 1-8.
- Iqbal O, Bramble W, Ottman A, O’Malley P, Gaynes J, De Alba F, Gaynes BI, Fareed J, Bouchard CS. Aspirin and its Metabolites Enhance the Expression of Vascular Endothelial Growth Factor in Retinal Pigment Epithelial Cell Cultures – Implications in the Pathophysiology of Age-Related Macular Degeneration. International Journal of Ophthalmology and Eye Science. 2015 August. 3(7), 115-120. doi: dx.doi.org/10.19070/2332-290X-1500025.
- Raiji VR, Eliott D, Sadda SR. Macular Hole Overlying Pigment Epithelial Detachment After Intravitreal Injection with Ranibizumab. Retinal Cases and Brief Reports. 2013 November; 7(1): 91-94. doi: 10.1097/ICB.0b013e31826f090d. PMID: 25390533.
Retinal Manifestations of Systemic Diseases
We have described retina findings in patients with different unusual systemic diseases improving our ability to help diagnose these systemic illnesses with the help of the ophthalmologist.
Research Team
Publications
- Harjasouliha A, Raiji VR, Garcia Gonzalez JM. Review of Hypertensive Retinopathy. Disease-a-Month. 2017 March; 63(3): 63-69. DOI: 10.1016/j.disamonth.2016.10.002. PMID: 27931746.
- Star M, Gill R, Bruzzone M, de Alba F, Biller J, Schneck MJ. Do not forget Susac syndrome in Patients with Unexplained acute confusion. Journal of Stroke and Cerebrovascular Diseases. 2015 April; 24(4): 93-95. doi: 10.1016/j.jstrokecerebrovasdis.2014.11.028. PMID: 25680663.
Retinal Manifestations of Systemic Medications
We have identified visual side effects of a common class of oral medications demonstrating it can occur with multiple drugs within the class.
Research Team
Publications
- Nguyen AB, Iqbal O, Block RC, Mousa SA. Prevention and treatment of atherothrombosis: Potential impact of nanotechnology. Vascul Pharmacol. 2022 Nov 11;148:107127. doi: 10.1016/j.vph.2022.107127. Epub ahead of print. PMID: 36375733.
- Rosen SM, Kaja S, De Alba F. Transient Colorblindness Associated with Sildenafil and Tadalafil. JAMA Ophthalmology. 2019 January; 137(1): 117-118. doi: 10.1001/jamaophthalmol.2018.4716. PMID: 30286227.
Uveitis
- Effects of Vascular endothelial growth factor (VEGF)
We have described different infectious and inflammatory conditions affecting the eye as well as proposed various emerging treatment for this diseases of the Uvea.
Research Team
Publications
- Hunter, MA. What to Do When you See Uveitis. Review Education Group. Release Date August 15, 2021.
- Schechet SA, Kotlyar B, Raiji VR. Multimodal Imaging of Double Schlaegel Lines. Ophthalmology Retina. 2019 May; 3(5): 443. DOI: 10.1016/j.oret.2019.01.008. PMID: 31044737.
- Chen TH, Hariprasad SM, Raiji VR. Update on Emerging Steroid-Based Local Treatments for Noninfectious Uveitis. Ophthalmic Surgery Lasers Imaging Retina. 2018 November; 49(11): 828-831. DOI: 10.3928/23258160-20181101-02. PMID: 30457640.
- Cunningham C, Widder Jered, Raiji VR. Endophthalmitis. Disease-a-Month. 2017 February; 63(2): 45-48. DOI: 10.1016/j.disamonth.2016.09.005. PMID: 27863689.
- Birnbaum AD, Jiang Y, Vasaiwala R, Tessler HH, Goldstein DA. Bilateral simultaneous-onset nongranulomatous acute anterior uveitis: clinical presentation and etiology. Archive Ophthalmology. 2012 November; 130 (11): 1389-94. DOI: 10.1001/archophthalmol.2012.2006. PMID: 22777605.