Program for Experimental and Theoretical Modeling (PETM)
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In the Program for Experimental & Theoretical Modeling (PETM), Division of Hepatology at Loyola University Chicago Medical Center, we conduct research at the interface of experimental and theoretical biology with an emphasis on viral infection dynamics and treatment response with a particular focus on hepatitis viruses (e.g. HCV, HEV, HBV and HDV). We apply our interdisciplinary approach across both in vitro and in vivo experimental systems as well as population and patient clinical data with the aim to find and optimize interventions and therapeutics that may ultimately prevent and/or cure these infections. Our experimental group performs viral infection experiments in cell cultures and small animal models that provide the basis for developing mathematical models at a molecular level. We also collaborate closely with public health researchers in Chicago and clinicians in our Division of Hepatology as well as many other clinicians in the US and abroad who provide viral–host-drug kinetic data from patients during infection and treatment. Together, our unique combination of experimental virology and theoretical modeling helps provide new insights into the dynamics of viral-host-drug interactions during infection and treatment from the molecular to the population level.
Dr. Harel Dahari Dr. Susan Uprichard
Co- Director Co- Director